초록 ▼

An implantable apparatus for sensing biological signals from an animal includes at least two electrodes disposed at locations to sense the biological signals. The electrode locations may be internal or external to the animal. Insulated conductors couple the electrodes via a passive network of filter

An implantable apparatus for sensing biological signals from an animal includes at least two electrodes disposed at locations to sense the biological signals. The electrode locations may be internal or external to the animal. Insulated conductors couple the electrodes via a passive network of filters to an instrumentation amplifier that has an internal voltage reference. Thus a sensed biological signal is filtered and amplified to provide an amplified differential signal. A signal analysis module processes amplified differential signal to determine at least one physiological parameter of the animal. The signal analysis module may include a first derivative zero detector for signal transition detection and feature detection and analysis. The apparatus may also comprise a signal presentation module to display amplified signals and physiological parameters associated with those signals.

대표청구항 ▼

1. An apparatus for sensing biological signals from an animal, the apparatus comprising: at least one set of electrodes that is adapted to be placed in contact with tissue of the animal at a set of locations to sense biological signals;a set of insulated conductors connected to the at least one set

1. An apparatus for sensing biological signals from an animal, the apparatus comprising: at least one set of electrodes that is adapted to be placed in contact with tissue of the animal at a set of locations to sense biological signals;a set of insulated conductors connected to the at least one set of electrodes, the set of insulated conductors formed in a configuration adapted to be substantially immune to electromagnetic interference;a network of filters connected to the set of insulated conductors and configured to filter the biological signals and thereby produce filtered biological signals;an amplifier connected to the network of filters and having an internal voltage reference, the amplifier configured to amplify the filtered biological signals to provide an amplified differential signal, wherein the internal voltage reference also is connected to a node in the network of filters;an energy source for powering at least the amplifier and configured to be free of all ground connections external to the apparatus; anda signal analysis module configured to receive and analyze the amplified differential signal to determine at least one physiological parameter of the animal. 2. The apparatus as recited in claim 1 further comprising at least one of a signal presentation module configured to display the amplified differential signal and a recording module to at least one of present and record the amplified differential signal. 3. The apparatus as recited in claim 1 wherein the set of locations of the at least one implantable electrode pair is on an external surface of the animal. 4. The apparatus as recited in claim 1 wherein the at least one physiological parameter is a heart rate of the animal. 5. The apparatus as recited in claim 1 wherein the network of filters comprises at least one high pass filter and at least one low pass filter. 6. The apparatus as recited in claim 5 wherein the at least one high pass filter is a single order filter. 7. The apparatus as recited in claim 5 wherein each of the at least one high pass filter and the at least one low pass filter is a passive filter comprising at least one capacitor and at least one resistor. 8. The apparatus as recited in claim 1 wherein the set of insulated conductors comprises multiple electrical conductors extending in parallel and spaced apart less than 3 mm. 9. The apparatus as recited in claim 1 wherein the signal analysis module comprises a first derivative zero detector. 10. The apparatus as recited in claim 1 wherein the network of filters comprises a low pass filter connected to the set of insulated conductors and including the node to which the internal voltage reference is connected. 11. The apparatus as recited in claim 10 wherein the low pass filter comprises a first element connected between the node and one conductor in the set of insulated conductors; and a second element connected between the node and another conductor in the set of insulated conductors. 12. An apparatus for sensing biological signals from an animal, the apparatus comprising: an electrode pair adapted for implantation in the animal at intravascular locations to sense biological signals;a pair of insulated conductors connected to the at least one electrode pair;a passive network of filters connected to the pair of insulated conductors and configured to filter the biological signals and thereby produce filtered biological signals;an instrumentation amplifier connected to the passive network of filters and having an internal voltage reference, the instrumentation amplifier being configured to amplify the filtered biological signals to produce an amplified signal, wherein the internal voltage reference also is connected to a node in the passive network of filters; andan energy source powering the apparatus and being isolated from all ground connections to the animal and external to the animal; anda signal analysis module configured to analyze the amplified signal. 13. The apparatus as recited in claim 12 wherein the passive network of filters comprises a low pass filter, a high pass filter, and a noise filter. 14. The apparatus as recited in claim 12 wherein the signal analysis module contains at least one first derivative zero detector. 15. The apparatus as recited in claim 12 wherein the passive network of filters comprises a low pass filter that includes the node to which the internal voltage reference is connected. 16. The apparatus as recited in claim 15 wherein the low pass filter comprises a first element connected between the node and one of the pair of insulated conductors; and a second element connected between the node and another one of the pair of insulated conductors. 17. An apparatus for sensing biological signals from an animal, the apparatus comprising: at least one electrode pair disposed at a first set of locations to sense biological signals;a pair of insulated conductors connected to the at least one electrode pair, the pair of insulated conductors being closely spaced to minimize sensitivity to electromagnetic interference;an internal reference module configured to provide an internal reference voltage;a filter network connected to the pair of insulated conductors and configured to provide a filtered biological signal, the filter network comprising at least one high pass filter and at least one low pass filter, the high pass filter configured to provide AC coupling and the low pass filter configured to provide noise rejection, wherein the internal reference voltage is applied to a node of one of the at least one low pass filter;an instrumentation amplifier connected to the filter network, the instrumentation amplifier configured to receive the internal reference voltage, and to amplify the filtered biological signal to provide an amplified biological signal;an energy source powering the apparatus, the energy source configured to be free of a wired connection to an energy supply external to the animal; anda signal analysis module configured to analyze the amplified differential signal to extract at least one physiological parameter of the animal;wherein the apparatus is substantially free of all wired ground connections to a ground external to the apparatus. 18. The apparatus as recited in claim 17 wherein the signal analysis module contains at least one first derivative zero detector. 19. The apparatus as recited in claim 17 wherein the first set of locations of the at least one electrode pair is on an external surface of the animal. 20. The apparatus as recited in claim 17 wherein the first set of locations of the at least one electrode pair is inside the animal.