초록

The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.

대표청구항 ▼

1. A method of treating cancer in a subject, comprising administering to the subject a chemosensitizing agent selected from the group consisting of gossypol, apogossypol, derivatives of apogossypol, in combination with an anticancer agent wherein said cancer is selected from lung cancer, breast canc

1. A method of treating cancer in a subject, comprising administering to the subject a chemosensitizing agent selected from the group consisting of gossypol, apogossypol, derivatives of apogossypol, in combination with an anticancer agent wherein said cancer is selected from lung cancer, breast cancer, prostate cancer, colorectal cancer, and leukemia. 2. The method of claim 1 wherein the derivative of aposossypol is a compound having formula (I): wherein: each R6, R8, R9 and R10 is independently hydrogen, hydroxyl, —(C1-C6)alkyl, —O(C1-C6)alkyl, —(C1-C6)alkylhalo, —OC(O)(C1-C6)alkyl, or halo; each R7 is independently hydrogen, —(C3-C8)cycloalkyl, —(C6-C10)aryl, or —(C1-C6)alkyl(C6-C10)aryl; or a pharmaceutically acceptable salt thereof. 3. The method of claim 2 wherein each R6, R8, R9, and R10 group is independently hydrogen, —OH, —OCH3, —CF3, —CH3, —OC2H5, —OC(O)CH3, F, Cl, or Br. 4. The method of claim 2 wherein each R7 group is independently hydrogen, —C2H5; -i-Pr, n-Pr, n-Bu, t-Bu, i-Bu, s-Bu, or cyclohexyl. 5. The method of claim 2 wherein each R6, R8, and R9, is —OC(O)CH3; each R7 is i-propyl; and each R10 is —CH3. 6. The method of claim 1 wherein the chemosensitizing agent and the anticancer agent are administered at the same time. 7. The method of claim 1 wherein the chemosensitizing agent is administered prior to the anticancer agent. 8. The method of claim 1 wherein the anticancer agent is Flavopiridol, Adriamycin, Etoposide, Taxol, cisplatin or a combination thereof. 9. The method of claim 1 wherein the leukemia is acute lymphocytic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia, or chronic myelogenous leukemia.