초록 ▼

Various processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enz

Various processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enzymes to the mixture in an amount sufficient to at least partially degrade the pomegranate solids; heating the mixture to a temperature that permits the maximum rate of catalysis of the enzyme; maintaining the temperature of the heated mixture for a time sufficient to allow at least partial degradation of the pomegranate solids; and removing residual insoluble solid materials from the mixture. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements. The compositions may also be used for preventing or ameliorating disease conditions by administering an effective amount of the composition to a subject in need thereof.

대표청구항 ▼

1. A method of treating a subject with erectile dysfunction, said method comprising the steps of administering to said subject a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein said extract is prepared by a process comprising the steps of: providing

1. A method of treating a subject with erectile dysfunction, said method comprising the steps of administering to said subject a composition comprising a therapeutically effective amount of an extract from pomegranate, wherein said extract is prepared by a process comprising the steps of: providing one or more pomegranate solids selected from the group consisting of pericarp, inner membrane and seeds;creating a mixture comprising said pomegranate solids in an aqueous solution;crushing said mixture to create a rough grind of pomegranate solids dispersed in said aqueous solution;adding enzymes to said mixture;heating said mixture to a temperature that permits catalysis of said enzymes;maintaining said mixture at said temperature for a time sufficient to allow at least partial degradation of said pomegranate solids;removing residual insoluble solid material from said mixture after said partial degradation has occurred to produce a liquid extract;concentrating said liquid extract in an evaporator under vacuum; andpasteurizing said liquid extract. 2. The method of claim 1 further comprising: wherein said heating of said mixture is to a temperature of about 60° F. to 210° F. 3. The method of claim 1 further comprising: wherein said aqueous solution comprises water in amount that is about 20-80% w/v of said pomegranate solids. 4. The method of claim 1 further comprising: adding a clarification agent before removing said residual insoluble material from said mixture. 5. The method of claim 1 wherein said enzymes comprise at least one of: pectinase, cellulose, hemicellulose, amylase, and arabanase. 6. The method of claim 1 wherein said enzymes are synthetic. 7. The method of claim 1 wherein enzymes comprise a mixture of pectinase, cellulose and hemicellulose enzymes; and wherein said mixture is heated to a temperature of about 60° F. to 210° F. 8. The method of claim 1 further comprising: stirring said mixture at said temperature for about 45-195minutes. 9. The method of claim 1 further comprising: pasteurizing said extract at a temperature of about 140° F.-280° F. 10. The method of claim 1 wherein said residual insoluble material is removed from said mixture by filtration, centrifugation, or chromatographic techniques. 11. The method of claim 10 wherein said filtration techniques include micro-filtration at a molecular weight cut-off of at least 1,000 Da.