Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
대표청구항▼
1. A functionalized substrate comprising a porous base substrate and a grafted or ungrafted coating of a carbonyl-functional (co)polymer functionalized with pendent guanidinyl groups on the surface thereof, said pendent guanidinyl groups are of the formula: wherein R1 is H, C1-C12 alkyl, or C5-C12
1. A functionalized substrate comprising a porous base substrate and a grafted or ungrafted coating of a carbonyl-functional (co)polymer functionalized with pendent guanidinyl groups on the surface thereof, said pendent guanidinyl groups are of the formula: wherein R1 is H, C1-C12 alkyl, or C5-C12 (hetero)aryl,R2 is a covalent bond, a C2 to C12 alkylene, or a C5-C12 (hetero)arylene,a R9 is C2 to C12 alkylene or C5-C12 (hetero)arylene,each R3 is independently H, —OH, C1-C12 alkyl, or C5-C12 (hetero)aryl,each R4 is H, C1-C12 alkyl, C5-C12 (hetero)aryl, or —N(R3)2. 2. The functionalized substrate of claim 1 wherein the pendent guanidinyl groups are of the formula: wherein R1 is H, C1-C12 alkyl, or C5-C12 (hetero)aryl,R9 is C2 to C12 alkylene or C5-C12 (hetero)arylene,each R3 is independently H, —OH, C1-C12 alkyl, or C5-C12 (hetero)aryl,each R4 is H, C1-C12 alkyl, C5-C12 (hetero)aryl, or —N(R3)2, preferably H, or C1-C4 alkyl,R5 is a divalent alkylene. 3. The functionalized substrate of claim 1 wherein the carbonyl-functional (co)polymer is selected from the group consisting of copolymers of; acrolein, vinyl methyl ketone, vinyl ethyl ketone, vinyl isobutyl ketone, diacetone (meth)acrylamide, acetonyl acrylate, carbon monoxide copolymer, and diacetone (meth)acrylate. 4. The functionalized substrate of claim 2 wherein the (co)polymer comprises polymerized monomer units of the formula: VI wherein R1 is H, C1-C12 alkyl, or C5-C12 (hetero)aryl,R2 is a covalent bond, a C2 to C12 alkylene, or a C5-C12 (hetero)arylene,a R9 is C2 to C12 alkylene or C5-C12 (hetero)arylene,each R3 is independently H, —OH, C1-C12 alkyl, or C5-C12 (hetero)aryl,R4 is H, C1-C12 alkyl, C5-C12 (hetero)aryl, or —N(R3)2,X is —O— or —NR3—R6 is a C2 to C12 alkylene, andR7 is H or CH3. 5. The functionalized substrate of claim 2 where the (co)polymer comprises polymerized monomer units of the formula: wherein R1 is H, C1-C12 alkyl, or C5-C12 (hetero)aryl,R2 is a covalent bond, a C2 to C12 alkylene, or a C5-C12 (hetero)arylene, R9 is C2 to C12 alkylene or C5-C12 (hetero)arylene,each R3 is independently H, C1-C12 alkyl, or C5-C12 (hetero)aryl, preferably H or C1-C4 alkyl,R4 is H, C1-C12 alkyl, C5-C12 (hetero)aryl, or —N(R3)2, preferably H, or C1-C4 alkyl,andR7 is H or CH3. 6. The functionalized substrate of claim 2 where the (co)polymer further comprises hydrophilic monomer units. 7. The functionalized substrate of claim 2 wherein the (co)polymer has the formula: -(MLig)y-(MHydrophil)x--(Mhydrophob)z-(MCO)w*-,where-(MCO)w are carbonyl functional monomer units having “w” polymerized monomer units,-(MHydrophil)x- are hydrophilic monomer units having “x” polymerized monomer units,-(Mhydrophob)z- are hydrophobic monomer units having “z” polymerized monomer units(MLig)y are ligand functional monomer units having “y” polymerized monomer units,y is 10 to 100 wt. % of the monomer units;x is 0 to 90 wt. % of the monomer units; andw* may be comprise 0 to 90 wt. % of the monomer units, andz is 0 to 20 wt. %, based on 100 wt. % total monomers. 8. The functionalized substrate of claim 1 wherein the ligand-functionalized polymer is coated on the porous substrate. 9. The functionalized substrate of claim 1 wherein the ligand-functionalized polymer is grafted on the substrate. 10. The functionalized substrate of claim 1 wherein the porous base substrate is a microporous base substrate. 11. The functionalized substrate of claim 1 wherein the porous base substrate is a nonwoven web. 12. A method of separating a biological species from a fluid comprising contacting the fluid with the functionalized substrate of claim 1 whereby a complex comprising the functionalized substrate and the biological species is formed, and separating the complex. 13. The method of claim 12 wherein the biological species are selected from cells, cell debris, viruses, proteins, nucleic acids, and endotoxins. 14. The method of claim 12 where the functionalized substrate is selected from a particle, a fiber, a film, or a sheet. 15. The method of claim 12 where the functionalized substrate is a woven or nonwoven web.
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