초록 ▼

Devices and methods are described for delivery of therapeutic substances to a depth within the heart muscle via the venous side of the heart, with a primary focus on delivery through the coronary sinus. The devices and methods may be combined with percutaneous access catheters in order to provide fo

Devices and methods are described for delivery of therapeutic substances to a depth within the heart muscle via the venous side of the heart, with a primary focus on delivery through the coronary sinus. The devices and methods may be combined with percutaneous access catheters in order to provide for right heart delivery of therapeutic agents.

대표청구항 ▼

1. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery elemen

1. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;an occluding mechanism disposed about the drug delivery catheter a short distance proximal to the penetrating element, said occluding mechanism adapted to occlude the ostium of the coronary sinus when placed in proximity thereto; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable matrix contained within the reservoir, said reservoir in communication with the drug delivery lumen. 2. The system of claim 1 wherein the occluding mechanism is further characterized by a proximal face and wherein the proximal face of the occluding mechanism is adapted to occlude the ostium of the coronary sinus. 3. The system of 2 wherein the distance between the penetrating element and the proximal face of the occluding mechanism approximates the expected length of the coronary venous system between the ostium and the target site of cardiac tissue. 4. The system of claim 1 wherein the occluding mechanism is an inflatable balloon. 5. The system of claim 4 wherein the balloon is characterized by a proximal face and wherein the proximal face of the balloon is adapted to occlude the ostium of the coronary sinus. 6. The system of claim 5 wherein the distance between the penetrating element and the proximal face of the balloon approximates the expected length of the coronary venous system between the ostium and the target site of cardiac tissue. 7. The system of claim 1 wherein the short distance between the penetrating element and the occluding mechanism approximates the expected length of the coronary venous system between the ostium and the target site of cardiac tissue. 8. The system of claim 1, wherein the target site is within the posterior vein of the left ventricle. 9. The system of claim 1 wherein the therapeutic agent further comprises VEGF. 10. The system of claim 1 wherein the therapeutic agent further comprises an angiogenic agent. 11. The system of claim 1 wherein the therapeutic agent further comprises an anti-restenosis agent. 12. The system of claim 1 wherein the short distance is sufficient to place the occluding mechanism in occluding relationship to the ostium of the coronary sinus while placing the penetrating element at the target site. 13. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;a guide catheter slidably disposed about the drug delivery catheter, said guide catheter having a proximal end and a distal end, said distal end of the guide catheter adapted for insertion into the coronary sinus;an occluding mechanism disposed about the guide catheter, said occluding mechanism adapted to occlude the ostium of the coronary sinus; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable matrix contained within the reservoir, said reservoir in communication with the drug delivery lumen. 14. The system of claim 13 wherein the therapeutic agent further comprises VEGF. 15. The system of claim 13 wherein the therapeutic agent further comprises an angiogenic agent. 16. The system of claim 13 wherein the therapeutic agent further comprises an anti-restenosis agent. 17. The system of claim 13 wherein the distance between the penetrating element and the occluding element is adjustable to permit movement of the penetrating element within the coronary venous system while the occluding mechanism is in proximity to the ostium of the coronary sinus. 18. The system of claim 13 wherein the distance between the penetrating element and the occluding element approximates the expected length of the coronary venous system between the ostium and the target site of cardiac tissue. 19. The system of claim 13, wherein the occluding mechanism is an inflatable balloon, and wherein the distance between the penetrating element and the proximal face of the balloon approximates the expected length of the coronary venous system between the ostium and the target site of cardiac tissue. 20. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;an occluding mechanism disposed about the drug delivery catheter a short distance proximal to the penetrating element, said occluding mechanism adapted to occlude the ostium of the coronary sinus when placed in proximity thereto; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising a polymeric matrix contained within the reservoir, said reservoir in communication with the drug delivery lumen. 21. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;an occluding mechanism disposed about the drug delivery catheter a short distance proximal to the penetrating element, said occluding mechanism adapted to occlude the ostium of the coronary sinus when placed in proximity thereto; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising a hydrogel contained within the reservoir, said reservoir in communication with the drug delivery lumen. 22. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;an occluding mechanism disposed about the drug delivery catheter a short distance proximal to the penetrating element, said occluding mechanism adapted to occlude the ostium of the coronary sinus when placed in proximity thereto; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable matrix comprising fibrin glue contained within the reservoir, said reservoir in communication with the drug delivery lumen. 23. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;an occluding mechanism disposed about the drug delivery catheter a short distance proximal to the penetrating element, said occluding mechanism adapted to occlude the ostium of the coronary sinus when placed in proximity thereto; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising microspheres contained within the reservoir, said reservoir in communication with the drug delivery lumen. 24. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising: a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;a guide catheter slidably disposed about the drug delivery catheter, said guide catheter having a proximal end and a distal end, said distal end of the guide catheter adapted for insertion into the coronary sinus;an occluding mechanism disposed about the guide catheter, said occluding mechanism adapted to occlude the ostium of the coronary sinus; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising a polymeric matrix contained within the reservoir, said reservoir in communication with the drug delivery lumen. 25. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising:a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;a guide catheter slidably disposed about the drug delivery catheter, said guide catheter having a proximal end and a distal end, said distal end of the guide catheter adapted for insertion into the coronary sinus;an occluding mechanism disposed about the guide catheter, said occluding mechanism adapted to occlude the ostium of the coronary sinus; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising a hydrogel contained within the reservoir, said reservoir in communication with the drug delivery lumen. 26. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising:a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;a guide catheter slidably disposed about the drug delivery catheter, said guide catheter having a proximal end and a distal end, said distal end of the guide catheter adapted for insertion into the coronary sinus;an occluding mechanism disposed about the guide catheter, said occluding mechanism adapted to occlude the ostium of the coronary sinus; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising fibrin glue contained within the reservoir, said reservoir in communication with the drug delivery lumen. 27. A system for treating the heart by injecting therapeutic agents into a target site within the coronary venous system, said system comprising: a device comprising:a drug delivery catheter having a proximal end and a distal end, said drug delivery catheter having a penetrating drug delivery element disposed on the distal end and a drug delivery lumen extending from the proximal end to the distal end of said drug delivery catheter;a guide catheter slidably disposed about the drug delivery catheter, said guide catheter having a proximal end and a distal end, said distal end of the guide catheter adapted for insertion into the coronary sinus;an occluding mechanism disposed about the guide catheter, said occluding mechanism adapted to occlude the ostium of the coronary sinus; anda reservoir; and a potentially embolic therapeutic agent comprising an implantable controlled release matrix comprising microspheres contained within the reservoir, said reservoir in communication with the drug delivery lumen.