Calcium-containing structures and methods of making and using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/00
A61K-033/14
A01N-059/08
출원번호
US-0030578
(2000-07-07)
등록번호
US-8389017
(2013-03-05)
국제출원번호
PCT/US00/18712
(2000-07-07)
§371/§102 date
20020429
(20020429)
국제공개번호
WO01/03709
(2001-01-18)
발명자
/ 주소
Starling, L. Brian
Stephan, James E.
출원인 / 주소
Cap Biotechnology, Inc.
인용정보
피인용 횟수 :
10인용 특허 :
40
초록▼
The present invention generally relates to calcium-containing structures and methods of making and using the structures. In one aspect, hollow calcium containing microstructures are used in conjunction with bone tissues/by-products to augment bone defects and extend the supply of bone tissues/by-pro
The present invention generally relates to calcium-containing structures and methods of making and using the structures. In one aspect, hollow calcium containing microstructures are used in conjunction with bone tissues/by-products to augment bone defects and extend the supply of bone tissues/by-products for bone augmentation. Bonding agents, such as calcium cements, are also used in the preparation of the hollow calcium microstructures combined with bone tissues/by-products or for use in preparing the hollow microstructures. The calcium-containing microstructures of the present invention are also useful as delivery vehicles of nitric oxide and/or nitric oxide containing or producing compounds for a variety of in vitro and in vivo uses. Calcium containing contoured substrates upon which cells/tissues can be grown in vitro for replacement and repair of tissues in vivo that conform in size and shape to the tissue surface to be replaced are also provided.
대표청구항▼
1. A bone grafting composition comprising (i) a bone graft material selected from the group consisting of cancellous bone, de-mineralized bone matrix (DBM) and mixtures thereof, wherein the bone graft material is from about 5% to about 95% by volume of the composition and(ii) a bone graft extender c
1. A bone grafting composition comprising (i) a bone graft material selected from the group consisting of cancellous bone, de-mineralized bone matrix (DBM) and mixtures thereof, wherein the bone graft material is from about 5% to about 95% by volume of the composition and(ii) a bone graft extender comprising hollow calcium-containing microstructures. 2. The composition of claim 1, wherein the microstructures are about 0.5 mm to about 6 mm in diameter. 3. The composition of claim 1, wherein the bone graft material comprises bone tissues or bone by-products. 4. The composition of claim 1, wherein the bone graft material is from about 50% to about 75% by volume of the composition. 5. The composition of claim 1, wherein the calcium-containing microstructures comprise hydroxylapatite, tribasic calcium phosphate, dicalcium phosphate, tetracalcium phosphate, calcium carbonate, calcium oxide, glass-containing calcium phosphate, or a mixture thereof. 6. The composition of claim 1, wherein the composition further comprises a bonding agent. 7. The composition of claim 6, wherein the bonding agent is a polymer. 8. The composition of claim 7, wherein the polymer is selected from the group consisting of polylactic acid, polyglycolic acid, polycaprolactone, poly α-hydroxy esters, polyphosphazenes, polyanhydrides, and polypropylene fumarate. 9. The composition of claim 6, wherein the bonding agent is a calcium-containing cement. 10. The composition of claim 9, wherein the calcium-containing cement is from about 5% to about 75% by volume of the composition. 11. The composition of claim 10, wherein the calcium-containing cement is from about 10% to about 50% by volume of the composition. 12. The composition of claim 9, wherein the calcium-containing cement is calcium phosphate, calcium sulfate or a mixture thereof. 13. The composition of claim 9, wherein the calcium-containing cement comprises calcium sulfate. 14. The composition of claim 1, wherein the calcium-containing microstructures comprise a mixture of at least two or more compounds selected from the group consisting of hydroxylapatite, tribasic calcium phosphate, dicalcium phosphate, tetracalcium phosphate, calcium carbonate, calcium oxide and glass-containing calcium phosphate. 15. The composition of claim 1, wherein the hollow calcium-containing microstructures comprise portals.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (40)
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable polymer composition.
Ducheyne Paul (Bryn Mawr PA) Cuckler John (Haverford PA) Radin Shulamit (Cherry Hill NJ), Calcium phosphate ceramics for bone tissue calcification enhancement.
Stephanopoulos Gregory (Winchester MA) Singhvi Rahul (Cambridge MA) Park Seujeung (Somerville MA) Flytzani-Stephanopoulos Maria (Winchester MA) Applegate Mark A. (San Diego CA), Cell-culturing apparatus and method employing a macroporous support.
Stephanopoulos Gregory (Winchester MA) Singhvi Rahul (Cambridge MA) Park Seujeung (Somerville MA) Flytzani-Stephanopoulos Maria (Winchester MA) Applegate Mark A. (San Diego CA), Cell-culturing apparatus and method employing a macroporous support.
Torobin Leonard B. (Materials Technology Corp.,Tower Place/Ste. 1425 ; 3340 Peachtree Rd. NE. Atlanta GA 30026), Hollow microspheres made from dispersed particle compositions and their production.
Lemons J. E. (c/o University of Alabama in Birmingham ; School of Dentistry ; Box 49 Birmingham AL 35294), Inorganic and organic composition for treatment of bone lesions.
Rosen Gerald M. ; Herzog ; Jr. William R. ; Pou Sovitj, Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosy.
Lange ; III Louis G. (216 S. Kingshighway Blvd. St. Louis MO 63178) Spilburg Curtis A. (St. Louis MO) Kinnunen Paula M. (University City MO), Method for recovering purified 100,000 dalton molecular weight fraction of human pancreatic cholesterol esterase.
Torobin Leonard B. (Microcel Technology ; Inc. 1 Ethel Rd. ; Ste. 108 Edison NJ 08817), Methods for producing hollow microspheres made from dispersed particle compositions.
Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic.
Trsch Walter (Stuttgart DEX) Kiefer Werner (Mainz DEX) Lohmann Karlheinz (Mainz DEX) Drolf Hans (Mainz DEX), Porous inorganic support spheres which can be cleaned of surface biomass under fluidized bed conditions.
Ammann Arthur J. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Beck Steven L. (460 Point San Bruno Blvd. South San Francisco CA 94080-4990) Nguyen Tue H. (460 Point San Bruno Blvd. So, TGF-b
상세보기
Guillemin Genevive (Paris FRX) Christel Pascal (Paris FRX) Patat Jean-Louis (Paris FRX) Meunier Alain (Coulommiers FRX), Use of porous polycrystalline aragonite as a support material for in vitro culture of cells.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.