Adsorbent filter media for removal of biological contaminants in process liquids
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01D-039/14
B01J-020/00
출원번호
US-0718336
(2010-03-05)
등록번호
US-8403153
(2013-03-26)
발명자
/ 주소
Yavorsky, David P.
출원인 / 주소
EMD Millipore Corporation
대리인 / 주소
Nields, Lemack & Frame, LLC
인용정보
피인용 횟수 :
2인용 특허 :
51
초록▼
Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent
Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid.
대표청구항▼
1. A porous composite monolith for removing biological contaminants in process liquids comprising: a compressed heat fused composite porous monolith having an adsorbent chromatography media material, and a water-insoluble thermoplastic binder dry mixture compressed to about 50-70% of the original vo
1. A porous composite monolith for removing biological contaminants in process liquids comprising: a compressed heat fused composite porous monolith having an adsorbent chromatography media material, and a water-insoluble thermoplastic binder dry mixture compressed to about 50-70% of the original volume of the composite porous monolith prior to and/or during heat fusing together the adsorbent chromatography media material and the thermoplastic binder, the composite porous monolith being substantially devoid of cellulose and a thermoset binder,wherein the thermoplastic binder includes polyolefins, polyethylene, polypropylene, ultra-high molecular weight polyethylene, or mixtures thereof, andthe ratio of thermoplastic binder to adsorbent chromatography media material ratio is about 1:1 to about 1:3 by weight. 2. The composite monolith of claim 1, wherein the adsorbent chromatography media material includes beads, powder, or particles, and the thermoplastic binder includes fibers, microfibers, beads or powder. 3. The composite monolith of claim 1, further comprising porous glass beads. 4. The composite monolith of claim 1, wherein the thermoplastic binder comprises ultra-high molecular weight polyethylene. 5. The composite monolith of claim 1, wherein the composite is formed by heating the adsorbent chromatography media material and the binder to a temperature at which the binder at least partially melts or softens to thermally bond the adsorbent chromatography media material together. 6. The composite monolith of claim 3, wherein the adsorbent chromatography media material has a particle size range about 0.2 microns to about 25 microns, the binder comprises ultra-high molecular weight polyethylene powder having an average particle size about 25 microns, and the porous glass beads have an average bead diameter about 20 microns to 30 microns. 7. The composite monolith of claim 1, having a thickness about 2 mm to about 4 mm. 8. The composite monolith of claim 7, further comprising an adsorbent filter media. 9. The composite monolith of claim 7, further comprising a pre-filter. 10. A biopharmaceutical clarification system, comprising: a) a bioreactor;b) a sterile filter downstream of the bioreactor; andc) a composite filter media downstream of the bioreactor and upstream of the sterile filter, the composite filter media including a heat fused composite porous monolith having an adsorbent chromatography media material and a water-insoluble thermoplastic binder dry mixture compressed to about 50-70% of the original volume of the composite porous monolith prior to and/or during heat fusing together the adsorbent chromatography media material and the thermoplastic binder, the composite filter media being substantially devoid of cellulose and a thermoset binder, wherein the thermoplastic binder includes polyolefins, polyethylene, polypropylene, ultra-high molecular weight polyethylene, or mixtures thereof, andthe ratio of thermoplastic binder to adsorbent chromatography media material is about 1:1 to about 1:3 by weight. 11. The biopharmaceutical clarification system of claim 10, further comprising an aqueous product stream feedstock from the bioreactor, pretreated through the composite filter media, the resulting filtrate being processed through the sterile filter.
Shaler Amos J. (705 W. Park Ave. State College PA 16801) McLean Daniel C. (4029 Alicante Fort Worth TX 76133), Adsorbent body and method for making same.
Groeger H. Gunter (Charlotte NC) Serad George A. (Charlotte NC) Felton Clinton D. (Charlotte NC), Fibrous structures containing immobilized particulate matter.
De Ruiter Ernest,DEX ; Toernblom Jonas,DEX, Filtering material and process for the production thereof, and adsorption filter produced from said filtering material.
Doi Yoshinao (Kawasaki JPX) Fujii Osamu (Tachikawa JPX) Kaneko Shigeo (Tokyo JPX) Hanamura Takeo (Tokyo JPX), Method for manufacturing a microporous film having low electrical resistance and high durability.
Leatherman Dennis D. (Pittsburgh PA) Rechlicz Thomas (Clinton OH) Schwarz Richard A. (Akron OH), Multilayer article of microporous and porous materials.
Degen Peter J. (Huntington NY) Gsell Thomas C. (Glen Cove NY), Self-supporting structures containing immobilized carbon particles and method for forming same.
Degen Peter J. (Huntington NY) Gsell Thomas C. (Levittown NY), Self-supporting structures containing immobilized inorganic sorbent particles and method for forming same.
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