Injection of fibrin sealant including an anesthetic in spinal applications
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/158
A61M-005/19
A61M-025/06
A61M-005/32
A61B-017/34
출원번호
US-0587312
(2009-10-05)
등록번호
US-8403895
(2013-03-26)
발명자
/ 주소
Pauza, Kevin
Burkinshaw, Brian D.
Whitlock, Steven I.
Richards, Mark I.
Rogan, James B.
출원인 / 주소
Spinal Restoration, Inc.
대리인 / 주소
O'Keefe, Egan, Peterman & Enders LLP
인용정보
피인용 횟수 :
0인용 특허 :
119
초록▼
A method of treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises an anest
A method of treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises an anesthetic, fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
대표청구항▼
1. A method of treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus, comprising: inserting a first needle having a tip by piercing the annulus fibrosus and pushing the first needle tip into the nucleus pulposus,inserting a polymeric catheter or a secon
1. A method of treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus, comprising: inserting a first needle having a tip by piercing the annulus fibrosus and pushing the first needle tip into the nucleus pulposus,inserting a polymeric catheter or a second needle into the first needle up to but not beyond the tip of the first needle,then injecting a fibrin sealant through the polymeric catheter or second needle, or both the first needle and the polymeric catheter or second needle, into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises an anesthetic, fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc. 2. The method of claim 1, with the proviso that neither the nucleus pulposus nor the annulus fibrosus has been heated. 3. The method of claim 1, wherein the fibrin sealant consists essentially of fibrinogen, the activating compound and the anesthetic, optionally at least one additive, and optionally calcium chloride. 4. The method of claim 1, wherein the fibrin sealant consists of fibrinogen, an activating compound and the anesthetic, optionally the at least one additive, and optionally containing calcium chloride. 5. The method of claim 1, wherein calcium chloride is injected with the fibrinogen and the activating compound. 6. The method of claim 1, wherein the activating compound is thrombin. 7. The method of claim 1, wherein the anesthetic is lidocaine, sarapin or bupivicaine. 8. The method of claim 1, wherein at least one additive is also injected. 9. The method of claim 1, wherein no portion of the nucleus pulposus has been removed by surgery. 10. The method of claim 1, wherein the at least one defect is a tear or fissure in the annulus fibrosus. 11. The method of claim 1, wherein normal hydrostatic pressure in the disc is restored. 12. The method of claim 1, wherein normal disc height is restored. 13. The method of claim 1, wherein the fibrinogen is autologous. 14. The method of claim 1, wherein the injection is performed using a dual barrel syringe. 15. The method of claim 1, wherein the activating compound is thrombin, and wherein a mixture of anesthetic, fibrinogen and thrombin is injected. 16. The method of claim 1, wherein the activating compound is thrombin, and wherein the fibrinogen and thrombin are injected sequentially and at least partially mix in the disc. 17. The method of claim 1, wherein the anesthetic is injected sequentially either before, with or after the fibrinogen and thrombin and at least partially mix in the disc. 18. The method of claim 1, wherein the disc is injected with the fibrin sealant at multiple points. 19. The method of claim 1, wherein the disc is a lumbar disc. 20. The method of claim 1, wherein the disc is a cervical disc. 21. The method of claim 1, wherein the disc is a thoracic disc. 22. The method of claim 1, wherein a contrast agent is injected either before the fibrin sealant, with the fibrin sealant, or after the fibrin sealant has been injected.
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