IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0926458
(2007-10-29)
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등록번호 |
US-8403907
(2013-03-26)
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발명자
/ 주소 |
- Sheppard, Jr., Norman F.
- Santini, Jr., John T.
- Cima, Michael J.
- Langer, Robert S.
- Ausiello, Dennis
|
출원인 / 주소 |
|
대리인 / 주소 |
Sutherland Asbill & Brennan LLP
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인용정보 |
피인용 횟수 :
2 인용 특허 :
82 |
초록
▼
A method is provided for monitoring the status of a medical device implanted in a patient. The method includes the steps of implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or senso
A method is provided for monitoring the status of a medical device implanted in a patient. The method includes the steps of implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics for disintegrating or permeabilizing the reservoir cap, and (iv) a telemetry system; and then using said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein.
대표청구항
▼
1. A method for monitoring the status of a medical device implanted in a patient, the method comprising: implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the re
1. A method for monitoring the status of a medical device implanted in a patient, the method comprising: implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics operable to melt each reservoir cap and thereby expose the drug or sensor to an environment at the site of implantation in the patient, and (iv) a telemetry system; andusing said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein. 2. The method of claim 1, further comprising using a microprocessor to compare the data transmitted to the remote controller with safety protocols stored in a memory. 3. The method of claim 2, wherein the reservoirs comprise at least one drug for release and the safety protocols prohibit (i) the release of an unsafe quantity of the drug to the patient over a particular time interval, and/or (ii) the unsafe release of two or more incompatible drugs. 4. The method of claim 1, further comprising transmitting the data received by the remote controller to the patient's physician or to a central monitoring system on a real-time basis. 5. The method of claim 1, wherein the data is transmitted in the form of electromagnetic energy selected from radio frequency signals, microwave signals, infrared signals, ultraviolet signals, and combinations thereof. 6. The method of claim 1, wherein the actuation electronics comprises components selected from the group consisting of multiplexers, demultiplexers, signal generators, signal oscillators, amplifiers, switches, potentiostats, and combinations thereof. 7. A method for monitoring the status of a medical device implanted in a patient, the method comprising: implanting at a site in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug formulation disposed in the two or more reservoirs, (iii) a power source and actuation electronics operable to melt each reservoir cap, thereby permitting the drug to be released from the medical device to the patient, and (iv) a telemetry system; andusing said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs caps have been or have yet to be disintegrated, melted, or otherwise ruptured. 8. The method of claim 7, wherein the drug formulation comprises a hormone, steroid, or chemotherapeutic agent. 9. A method for monitoring a medical device implanted in a patient, the method comprising: implanting in a patient a medical device which comprises (i) a silicon substrate in which two or more reservoirs are located, with each covered by a reservoir cap comprising a metal film, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics operable to cause a rise in temperature of each reservoir cap to disintegrate or melt each reservoir cap and thereby expose the drug or sensor to an environment at the site of implantation in the patient, and (iv) a telemetry system; andusing said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein.
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