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Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/566
  • C07K-014/705
출원번호 US-0852941 (2010-08-09)
등록번호 US-8404455 (2013-03-26)
발명자 / 주소
  • Li, Xiaodong
  • Staszewski, Lena
  • Xu, Hong
출원인 / 주소
  • Senomyx, Inc.
대리인 / 주소
    Hunton & Williams LLP
인용정보 피인용 횟수 : 23  인용 특허 : 40

초록

The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respe

대표청구항

1. A method for identifying putative sweet taste enhancer compounds comprising conducting a binding or functional assay using one or more compounds and identifying putative sweet enhancer compounds based on their specifically interacting with the Venus Flytrap Region of the human T1R2 receptor polyp

이 특허에 인용된 특허 (40)

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  7. Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and.
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  9. Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and.
  10. Lombardino Joseph G. (Niantic CT) Harbert Charles A. (Waterford CT), Certain 4-(2-hydroxyethylthiomethyl)pyridines and derivatives thereof having immunoregulatory activity.
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  28. Cook Phillip D. (Carlsbad CA) Kiely John (San Diego CA) Sprankle Kelly (Vista CA), Peptide nucleic acid combinatorial libraries and improved methods of synthesis.
  29. Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Positive-negative selection methods and vectors.
  30. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
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  32. Caruthers Marvin H. (Boulder CO) Matteucci Mark D. (Boulder CO), Process for preparing polynucleotides.
  33. Nofre Claude (Lyons FRX) Tinti Jean M. (Meyzieu FRX) Chatzopoulos Farroudja O. (Saint Etienne FRX), Pyridinyl compounds of N-carbamoyl-N-thiocarbamoyl- or N-amidino-glycine or beta-alanine useful as sweetening agents.
  34. Acevedo Oscar L. (San Diego CA) Hebert Normand (San Marcos CA), Pyrrolidine-containing monomers and oligomers.
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  39. Pausch Mark Henry (Robbinsville NJ) Ozenberger Bradley A. (Yardley PA) Hadcock John Richard (Mount Holly NJ) Price Laura Alicia (Langhorne PA) Kajkowski Eileen Marie (Ringoes NJ) Kirsch Donald Richar, Transformed yeast cells expressing heterologous G-protein coupled receptor.
  40. Adler, Jon Elliot; Li, Xiaodong; Staszewski, Lena; Xu, Hong; Echeverri, Fernando, Use of T1R hetero-oligomeric taste receptor to screen for compounds that modulate taste signaling.

이 특허를 인용한 특허 (23)

  1. Shigemura, Rhondi; Chen, Qing; Darmohusodo, Vincent; Dean, Aaron R., Comestible compositions comprising high potency savory flavorants, and processes for producing them.
  2. Bermudes, David Gordon, Compositions and methods for determining successful immunization by one or more vaccines.
  3. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Staszewski, Lena, Detection of human T1R expressing cells.
  4. Tachdjian, Catherine; Patron, Andrew P.; Adamski-Werner, Sara L.; Bakir, Farid; Chen, Qing; Darmohusodo, Vincent; Hobson, Stephen Terrence; Li, Xiaodong; Qi, Ming; Rogers, Daniel H.; Rinnova, Marketa; Servant, Guy; Tang, Xiao-Qing; Zoller, Mark; Wallace, David; Xing, Amy; Gubernator, Klaus, Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof.
  5. Tachdjian, Catherine; Patron, Andrew P.; Adamski-Werner, Sara L.; Bakir, Farid; Chen, Qing; Darmohusodo, Vincent; Hobson, Stephen Terrence; Li, Xiaodong; Qi, Ming; Rogers, Daniel H.; Rinnova, Marketa; Servant, Guy; Tang, Xiao-Qing; Zoller, Mark; Wallace, David; Xing, Amy; Gubernator, Klaus, Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof.
  6. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Alder, Jon Elliot; Xu, Hong; Echeverri, Fernando, In vitro method using hetero-oligomeric T1R1/T1R3 taste receptors to identify umami tastants.
  7. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of detecting T1R hetero-oligomeric taste receptor expression to identify cells that are potentially sensitive to sweet tastants.
  8. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of detecting umami tastant-sensitive cells which express heteromeric T1R1/T1R3 receptors.
  9. Bom, David C., Methods of modifying or imparting taste using organic compounds.
  10. Adler, Jon E.; Li, Xiaodong; Luukkonen, Lena; Xu, Hong; Echeverri, Fernando, Methods of screening T1R hetero-oligomeric taste receptors for sweet taste modulators.
  11. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 heteromeric receptors for compounds that modulate umami taste signaling.
  12. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 receptors for compounds that modulate umami taste signaling.
  13. Zoller, Mark; Li, Xiaodong; Staszewski, Lena; O'Connell, Shawn; Zozulya, Sergey; Adler, Jon Elliot; Xu, Hong; Echeverri, Fernando, Methods of screening T1R1/T1R3 receptors for compounds that modulate umami taste signaling.
  14. Adler, Jon E.; Li, Xiaodong; Staszewski, Lena; Xu, Hong; Echeverri, Fernando, Methods of screening heteromeric T1R2/T1R3 receptors for compounds which modulate sweet taste signaling.
  15. Adler, Jon E.; Li, Xiaodong; Luukkonen, Lena; Xu, Hong; Echeverri, Fernando, Methods of using TIR hetero-oligomeric receptors for screening compounds that modulate sweet or umami taste.
  16. Servant, Guy; Servant, Nicole, Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives.
  17. Abe, Keiko; Misaka, Takumi; Imada, Takamasa; Fujiwara, Satoshi, Sweet taste receptor-expressing construct, cell body expressing the same, and utilization thereof.
  18. Li, Xiaodong; Staszewski, Lena; Xu, Hong, T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds.
  19. Adler, Jon Elliot; Li, Xiaodong; Luukkonen, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  20. Adler, Jon Elliot; Li, Xiaodong; Luukkonen, Lena; O'Connell, Shawn; Zozulya, Sergey, T1R taste receptors and genes encoding same.
  21. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Luukkonen, Lena, T1R taste receptors and genes encoding same.
  22. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Luukkonen, Lena, T1R taste receptors and genes encoding same.
  23. Adler, Jon Elliot; Zozulya, Sergey; Li, Xiaodong; O'Connell, Shawn; Staszewski, Lena, T1R taste receptors and genes encoding same.
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