IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0538950
(2006-10-05)
|
등록번호 |
US-8409167
(2013-04-02)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
12 인용 특허 :
389 |
초록
Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.
대표청구항
▼
1. A method of treating diseased lung tissue in a lung, the method comprising: advancing a delivery catheter through a natural respiratory opening and into the lung;creating and maintaining an extra-anatomic opening in an airway wall at a target site such that patency of the extra-anatomic opening i
1. A method of treating diseased lung tissue in a lung, the method comprising: advancing a delivery catheter through a natural respiratory opening and into the lung;creating and maintaining an extra-anatomic opening in an airway wall at a target site such that patency of the extra-anatomic opening is artificially extended beyond a natural healing response; anddelivering a substance through the extra-anatomic opening to treat a region of diseased tissue beyond the airway wall in the lung. 2. The method of claim 1, further comprising: identifying the region of diseased tissue prior to delivering the substance; andselecting the target site. 3. The method of claim 2, where identifying the region in the lung having diseased tissue comprises locating a tumor in the lung. 4. The method of claim 3, further comprising delivering the substance through the extra-anatomic opening to treat the tumor. 5. The method of claim 2, where identifying the region in the lung having diseased tissue comprises locating a region of trapped gasses. 6. The method of claim 5, further comprising delivering the substance through the extra-anatomic opening to collapse the region of the lung containing the collapsed gasses. 7. The method of claim 2, where identifying the region in the lung having diseased tissue comprises locating the region using an imaging method selected from radiography, computer tomography, ultrasound, Doppler, MRI, PET and acoustic imaging. 8. The method of claim 2, where selecting the target site comprises scanning for the presence of a blood vessel in the airway wall to avoid puncturing the blood vessel during creation of the extra-anatomic opening. 9. The method of claim 8, where scanning the target site comprises using a modality selected from the group consisting of visual inspection, x-ray, ultrasound, Doppler, acoustic, MRI, PET, and computed tomography (CT) scans. 10. The method of claim 1, further comprising inserting an implant within the extra-anatomic opening. 11. The method of claim 10, further comprising removing the implant subsequently to delivering the substance. 12. The method of claim 1, wherein creating the extra-anatomic opening comprises using a needle-like member which punctures the tissue to create the extra-anatomic opening. 13. The method of claim 12, where the needle-like member delivers the substance. 14. The method of claim 1, where the substance comprises a substance selected from the group consisting of antimetabolites, antithrobotics, anticoagulants, antiplatelet agents, thorombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, agents that inhibit restenosis, smooth muscle cell inhibitors, growth factors, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters and a combination thereof. 15. The method of claim 1, where the substance comprises a substance selected from the group consisting of analgesics, anticonvulsives, antibiotics, antimicrobials, antineoplastics, Histamine 2 antagonists, steroids, non-steroidal anti-inflammatories, hormones, immunomodulators, mast cell stabilizers, nucleoside analogues, respiratory agents, antihypertensives, antihistamines, ACE inhibitors, cell growth factors, nerve growth factors, anti-angiogenic agents or angiogenesis inhibitors, tissue irritants, a compound comprising talc, poisons, cytotoxic agents, silver, aluminum, zinc, platinum, arsenic, epithelial growth factors, pyrolitic carbon, titanium-nitride-oxide, taxanes, fibrinogen, collagen, thrombin, phosphorylcholine, heparin, rapamycin, radioactive 188Re and 32P, silver nitrate, dactinomycin, sirolimus, everolimus, Abt-578, tacrolimus, camptothecin, etoposide, vincristine, mitomycin, fluorouracil, or cell adhesion peptides, and a combination thereof. 16. The method of claim 1, where maintaining the extra anatomic opening occurs by an act selected from the group consisting of applying a bio-active substance and implanting a conduit. 17. A method for locating and treating cancerous tissue in a lung comprising: advancing a device through an oral opening and into an airway within the lung;locating a target site along an airway wall, the target site being in the vicinity of the cancerous tissue; anddelivering a substance through an existing surgically created opening to treat the cancerous tissue beyond the airway wall in the lung where the existing surgically created opening was previously created such that patency of the surgically created opening is extended beyond at least creation of the surgically created opening. 18. The method of claim 17, further comprising sensing for a blood vessel prior to said delivering step. 19. The method of claim 17, further comprising preventing closure of the surgical opening wherein said preventing step is performed using a combination of mechanical and biochemical means. 20. The method of claim 19 where said delivering step comprises inserting an instrument through the surgical opening and injecting said substance from said instrument to the tissue. 21. The method of claim 17 where the tissue is a tumor. 22. The method of claim 17, where previously creating the existing surgically created opening included an act selected from the group consisting of applying a bio-active substance; dilating; piercing, and implanting a conduit.
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