Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
원문보기
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0990162
(2006-07-28)
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등록번호 |
US-8410109
(2013-04-02)
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국제출원번호 |
PCT/US2006/029827
(2006-07-28)
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§371/§102 date |
20080207
(20080207)
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국제공개번호 |
WO2007/016525
(2007-02-08)
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발명자
/ 주소 |
- Wong, Norman C. W.
- Hansen, Henrik C.
- Chiacchia, Fabrizio S.
- Johansson, Jan O.
|
출원인 / 주소 |
|
대리인 / 주소 |
Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
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인용정보 |
피인용 횟수 :
19 인용 특허 :
60 |
초록
▼
The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment
The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.
대표청구항
▼
1. A compound selected from 2-(4-hydroxy-3,5-dimethylphenyl)-4H-pyrano[2,3-b]pyridin-4-one;7-((dimethylamino)methyl)-2-(4-hydroxyphenyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;2-(4-(2-(dimethylamino)ethoxy)phenyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;2-(4-hydroxy-3-(thiophen-2-yl)phe
1. A compound selected from 2-(4-hydroxy-3,5-dimethylphenyl)-4H-pyrano[2,3-b]pyridin-4-one;7-((dimethylamino)methyl)-2-(4-hydroxyphenyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;2-(4-(2-(dimethylamino)ethoxy)phenyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;2-(4-hydroxy-3-(thiophen-2-yl)phenyl)-4H-pyrano[2,3-b]pyridin-4-one;2-(2,6-dimethyl-4-(4-oxo-4H-pyrano[2,3-b]pyridin-2-yl)phenoxy)acetic acid;2-(3,5-dimethyl-4-(2-morpholinoethoxy)phenyl)-4H-pyrano[2,3-b]pyridin-4-one hydrochloride;2-(4-hydroxy-3,5-dimethylphenyl)-6-(pyrrolidin-1-ylmethyl)-4H-pyrano[2,3-b]pyridin-4-one dihydrochloride;6-(4-oxo-4H-chromen-2-yl)benzo[d]oxazol-2(3H)-one;2-(4-fluorophenyl)-6-(pyrrolidin-1-ylmethyl)-4H-pyrano[2,3-b]pyridin-4-one hydrochloride;2-(4-isopropoxyphenyl)-6-(pyrrolidin-1-ylmethyl)-4H-pyrano[2,3-b]pyridin-4-one hydrochloride;7-(4-hydroxy-3,5-dimethylphenyl)-1,6-naphthyridin-5(6H)-one hydrochloride;2-hydroxy-7-(4-hydroxy-3,5-dimethylphenyl)-4-methoxy-1,6-naphthyridin-5(6H)-one dihydrochloride;3-(4-(2-hydroxy-2-methylpropoxy)-3,5-dimethylphenyl)-6,8-dimethoxyisoquinolin-1(2H)-one;2,6-dimethyl-4-(1-(methylamino)-7-((4-methylpiperazin-1-yl)methyl)isoquinolin-3-yl)phenol trihydrochloride;2-(quinoxalin-6-yl)-4H-pyrano[2,3-b]pyridin-4-one;4-(5-amino-2,4-dimethoxy-1,6-naphthyridin-7-yl)-2,6-dimethylphenol;2-(4-fluorophenyl)-6-(morpholinomethyl)quinazolin-4(3H)-one;2-(1H-indazol-5-yl)-6-(morpholinomethyl)-4H-pyrano[2,3-b]pyridin-4-one;3-(3,5-dimethyl-4-(2-morpholinoethoxy)phenyl)-6,8-dimethoxyisoquinolin-1(2H)-one; and6-((dimethylamino)methyl)-2-(pyridin-4-yl)-4H-chromen-4-one, and pharmaceutically acceptable salts thereof. 2. A pharmaceutical composition comprising a compound according to claim 1, and a pharmaceutically acceptable carrier.
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