Systems and methods for replacing signal artifacts in a glucose sensor data stream
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/05
A61B-005/00
출원번호
US-0023879
(2011-02-09)
등록번호
US-8412301
(2013-04-02)
발명자
/ 주소
Goode, Jr., Paul V.
Brauker, James H.
Kamath, Apurv U.
Thrower, James Patrick
Carr-Brendel, Victoria
출원인 / 주소
DexCom, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear, LLP
인용정보
피인용 횟수 :
22인용 특허 :
367
초록▼
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have hi
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
대표청구항▼
1. A method for processing data from a glucose sensor, comprising: monitoring a data stream from a glucose sensor;monitoring a pressure within the glucose sensor using a pressure detector;evaluating, using a processor module, the data stream and the monitored pressure; andoutputting or displaying, u
1. A method for processing data from a glucose sensor, comprising: monitoring a data stream from a glucose sensor;monitoring a pressure within the glucose sensor using a pressure detector;evaluating, using a processor module, the data stream and the monitored pressure; andoutputting or displaying, using an output module, information responsive to the evaluation of the data stream and the monitored pressure. 2. The method of claim 1, further comprising detecting transient non-glucose related signal artifacts in the data stream based at least in part on the evaluation, determining a severity of the signal artifacts, and replacing with an electronic device at least some of the signal artifacts with one or more estimated glucose values in response to the detection, wherein replacing transient non-glucose related signal artifacts further comprises selectively applying one of a plurality of signal estimation algorithm factors in response to the determined severity of the signal artifacts. 3. The method of claim 2, wherein the plurality of signal estimation algorithm factors comprise a single algorithm with a plurality of parameters that are selectively applied to the algorithm. 4. The method of claim 2, wherein the plurality of signal estimation algorithm factors comprise a plurality of distinct algorithms. 5. The method of claim 2, wherein selectively applying one of a plurality of signal estimation algorithm factors comprises selectively applying a predetermined algorithm that comprises a set of parameters whose values depend on the determined severity of the signal artifacts. 6. The method of claim 2, wherein detecting transient non-glucose related signal artifacts further comprises at least one of: testing for ischemia within or proximal to the glucose sensor; monitoring a level of pH proximal to the sensor; monitoring a temperature proximal to the sensor; comparing a level of pH proximal to and distal to the sensor; comparing a temperature proximal to and distal to the sensor; evaluating historical data for high amplitude noise above a predetermined threshold; performing a Cone of Possibility Detection Method; evaluating the data stream for a non-physiological rate-of-change; monitoring a frequency content of the data stream; performing an orthogonal basis function-based transform; performing a Fourier Transform; or performing a wavelet transform. 7. The method of claim 2, wherein replacing at least some of the signal artifacts comprises at least one of: performing linear or non-linear regression; performing a trimmed mean; filtering using a non-recursive filter; filtering using a finite impulse response filter; filtering using a recursive filter; filtering using an infinite impulse response filter; performing a maximum average algorithm; or performing a Cone of Possibility Replacement Method. 8. The method of claim 2, wherein replacing at least some of the signal artifacts is substantially continual. 9. The method of claim 2, further comprising discarding at least some of the signal artifacts. 10. The method of claim 2, wherein the information comprises the one or more estimated glucose values. 11. The method of claim 2, wherein the information comprises the data stream and the one or more estimated glucose values. 12. The method of claim 2, further comprising storing the one or more estimated glucose values. 13. The method of claim 2, further comprising displaying the one or more estimated glucose values. 14. The method of claim 1, wherein monitoring a data stream comprises receiving data from at least one of a non-invasive, a minimally invasive, or an invasive glucose sensor. 15. The method of claim 1, wherein monitoring a data stream comprises receiving data from at least one of an enzymatic, a chemical, a physical, an electrochemical, a spectrophotometric, a polarimetric, a calorimetric, an iontophoretic, or a radiometric glucose sensor. 16. The method of claim 1, further comprising calibrating the data stream and detecting transient non-glucose related signal artifacts in the calibrated data stream. 17. The method of claim 1, further comprising detecting transient non-glucose related signal artifacts in the data stream, the detecting comprising detecting high frequency cycles. 18. The method of claim 1, wherein the information comprises the data stream. 19. The method of claim 1, further comprising detecting transient non-glucose related signal artifacts in the data stream based at least in part on the evaluation, and replacing with an electronic device at least some of the signal artifacts with one or more estimated glucose values in response to the detection, wherein detecting transient non- glucose related signal artifacts further comprises using a time series analysis based on a variance of a signal over a window of data. 20. The method of claim 19, wherein the window of data is about 15 minutes. 21. The method of claim 19, wherein the window of data is about 30 minutes. 22. The method of claim 19, wherein the window of data is about 45 minutes. 23. The method of claim 19, wherein the window of data is about 60 minutes. 24. A method for processing data signals obtained from a glucose sensor, comprising: obtaining a data stream from a glucose sensor; anddetecting, using a processor module, transient non-glucose related signal artifacts in the data stream that have a higher amplitude than a system noise, the signal artifacts detection comprising monitoring a pressure or stress within the glucose sensor.
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이 특허에 인용된 특허 (367)
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Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
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