Method of making microneedle array and device for applying microneedle array to skin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/32
B22D-017/00
출원번호
US-0694314
(2010-01-27)
등록번호
US-8414548
(2013-04-09)
발명자
/ 주소
Yuzhakov, Vadim V.
출원인 / 주소
Yuzhakov, Vadim V.
대리인 / 주소
Sutherland Asbill & Brennan LLP
인용정보
피인용 횟수 :
6인용 특허 :
26
초록▼
Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate,
Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.
대표청구항▼
1. A method for manufacturing a microneedle array comprising providing a substantially planar substrate material;forming a plurality of first apertures in the substrate material, wherein the interior surface of at least one of the first apertures defines a microneedle having a tip, a base, and a bod
1. A method for manufacturing a microneedle array comprising providing a substantially planar substrate material;forming a plurality of first apertures in the substrate material, wherein the interior surface of at least one of the first apertures defines a microneedle having a tip, a base, and a body portion therebetween;forming a plurality of second apertures in the substrate material, each of the second apertures defining an elongated channel located in the body portion of the microneedle; andbending the microneedle near its base such that the tip and body portion project out of the plane of the substrate material,wherein the tip of the microneedle is tapered, the body portion is rectangular, and the channel extends through 50% to 99% of the length of the microneedle substantially from the planar substrate, through the base, and through at least a part of the body portion. 2. The method of claim 1, wherein the bending of the microneedle comprises direct or indirect application of a compressive force, heat, or a combination thereof, to the microneedle and/or substrate material. 3. The method of claim 1, wherein the substrate material and the microneedle comprise stainless steel or another biocompatible metal. 4. The method of claim 1, wherein the first apertures in the substrate material are polygonal in shape, each aperture being defined by three or more interior side surfaces in the substrate material. 5. The method of claim 1, wherein the microneedle has a length between 1 μm and 5000 μm. 6. The method of claim 1, wherein the microneedle has a length between 10 μm and 1000 μm. 7. The method of claim 1, wherein the microneedle has a width between 1 μm and 500 μm. 8. The method of claim 1, wherein the microneedle has a thickness between 1 μm and 200 μm. 9. The method of claim 1, wherein the steps of forming the first and second apertures comprise embossing, injection molding, casting, photochemical etching, electrochemical machining, electrical discharge machining, precision stamping, high-speed computer numerically controlled milling, Swiss screw machining, soft lithography, directional chemically assisted ion etching, or a combination thereof.
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이 특허에 인용된 특허 (26)
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Yuzhakov, Vadim Vladimirovich; Gartstein, Vladimir; Owens, Grover David, Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup.
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