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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0723169 (2010-03-12) |
등록번호 | US-8425743 (2013-04-23) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 454 |
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agen
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
1. A system comprising: a biosensor comprising a first electrode, a second electrode, a third electrode, and a reagent layer including a reagent which reacts specifically with glucose in a sample solution, which biosensor measures the concentration of the glucose in the sample solution, said reagent
1. A system comprising: a biosensor comprising a first electrode, a second electrode, a third electrode, and a reagent layer including a reagent which reacts specifically with glucose in a sample solution, which biosensor measures the concentration of the glucose in the sample solution, said reagent layer being present in a sample chamber of the sensor and including glucose dehydrogenase having a coenzyme; anda sensor reader configured to: apply a first potential between the first and second electrodes to determine when the sample chamber is beginning to fill with sample;apply a second potential between the first and third electrodes to determine with the sample chamber is substantially filled with sample;apply a third potential between the first and second electrodes to electrolyze the glucose, thereby generating a glucose signal; andmeasure the concentration of the glucose using the glucose signal. 2. A system as defined in claim 1, wherein the concentration of the glucose in the sample solution is measured using electrodes including at least a working electrode and a counter electrode, which electrodes are disposed in the sample chamber. 3. A system as defined in claim 2, wherein the reagent layer, including an electron carrier, is formed on the working electrode. 4. A system as defined in claim 2, wherein the working electrode and counter electrode are disposed in a facing configuration. 5. A system as defined in claim 2, wherein the working electrode and counter electrode are disposed in a coplanar configuration. 6. A system as defined in claim 2, wherein the working electrode and the counter electrode are separated by a closest distance that is no more than 100 μm. 7. A system as defined in claim 2, wherein the working electrode and the counter electrode are separated by a closest distance that is no more than 50 gm. 8. A system as defined in claim 2, wherein the biosensor comprises an indicator electrode disposed in the sample chamber. 9. A system as defined in claim 8, wherein the working electrode, counter electrode, and indicator electrode are disposed in a coplanar configuration. 10. A system as defined in claim 1 , wherein the reagent layer, including an electron carrier, is formed so that the electrodes are disposed in a diffusion area wherein the reagent of the reagent layer is dissolved in the sample solution and diffused. 11. A system as defined in claim 1 , wherein the biosensor comprises an electron carrier comprising: a transition metal selected from the group consisting of osmium, ruthenium, iron, and cobalt;two or more ligands coordinately bound to the transition metal, wherein at least one of the ligands is a heterocyclic nitrogen-containing bidentate ligand comprising wherein R1 is selected from hydrogen, hydroxy, alkyl, alkoxy, alkenyl, vinyl, allyl, amido, amino, vinylketone, keto, or sulfur-containing groups. 12. A system as defined in claim 11, wherein the transition metal is osmium. 13. A system as defined in claim 11, wherein R1 is an alkyl. 14. A system as defined in claim 13, wherein R1 is methyl. 15. A system as defined in claim 11, wherein at least one of the ligands is a unsubstituted or substituted pyridine. 16. A system as defined in claim 15, wherein at least one of the ligands is a monosubstituted pyridine. 17. A system as defined in claim 1, wherein the sample solution is blood obtained from the finger of a user. 18. A system as defined in claim 1, wherein the sample fluid is blood obtained from a region of a user having a lower nerve end density as compared to a fingertip. 19. A system as defined in claim 18, wherein the region of the user having a lower nerve end density as compared to a fingertip is selected from the group consisting of: a forearm region, and a thigh region. 20. A system as defined in claim 1, wherein the reagent layer comprises an electron carrier comprising ferricyanide or ferrocyanide. 21. A system as defined in claim 1, wherein the sample chamber is sized to contain a volume of no more than 1 μL of the sample fluid. 22. A system as defined in claim 1, wherein the sample chamber is sized to contain a volume of no more than 0.5 μL of the sample fluid.
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