Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-006/097
A61K-009/00
A61K-031/715
출원번호
US-0742457
(2008-11-14)
등록번호
US-8426492
(2013-04-23)
국제출원번호
PCT/US2008/083522
(2008-11-14)
§371/§102 date
20100512
(20100512)
국제공개번호
WO2009/064963
(2009-05-22)
발명자
/ 주소
Lu, Helen S. M.
출원인 / 주소
Actamax Surgical Materials, LLC
대리인 / 주소
McCarter and English
인용정보
피인용 횟수 :
7인용 특허 :
50
초록▼
A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing o
A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, ophthalmic procedures, drug delivery, anti-adhesive applications and as a bulking agent to treat urinary incontinence. Additionally, due to the presence of the positively charged amine groups on the oxidized polysaccharide, the polymer tissue adhesive disclosed herein may promote wound healing and blood coagulation, and may possess antimicrobial properties.
대표청구항▼
1. A kit comprising: a) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weig
1. A kit comprising: a) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons and an amine substitution level of about 5% to about 50%; and b) at least one water-dispersible, multi-arm amine wherein at least three of the arms are terminated by a primary amine group, wherein the multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons. 2. The kit according to claim 1, wherein the oxidized polysaccharide is a first aqueous solution or dispersion and the multi-arm amine is a second aqueous solution or dispersion. 3. The kit according to claim 1, wherein the oxidized polysaccharide and the multi-arm amine are finely divided powders. 4. The kit according to claim 1, wherein the oxidized polysaccharide containing aldehyde groups and amine groups is derived from a polysaccharide selected from the group consisting of dextran, carboxymethyldextran, starch, agar, cellulose, hydroxyethylcellulose, carboxymethylcellulose, pullulan, inulun, levan, agarose, and hyaluronic acid. 5. The kit according to claim 1, wherein the oxidized polysaccharide containing aldehyde groups and amine groups is oxidized diethylaminoethyl dextran or oxidized aminated dextran. 6. The kit according to claim 1, wherein the multi-arm amine is selected from the group consisting of water dispersible multi-arm polyether amines, amino-terminated dendritic polyamidoamines, and branched end amines. 7. The kit according to claim 6, wherein the water dispersible multi-arm polyether amines are selected from the group consisting of amino-terminated star polyethylene oxides, amino-terminated dendritic polyethylene oxides, amino-terminated comb polyethylene oxides, amino-terminated star polypropylene oxides, amino-terminated dendritic polypropylene oxides, amino-terminated comb polypropylene oxides, amino-terminated star polyethylene oxide-polypropylene oxide copolymers, amino-terminated dendritic polyethylene oxide-polypropylene oxide copolymers, amino-terminated comb polyethylene oxide-polypropylene oxide copolymers, and polyoxyalkylene triamines. 8. The kit according to claim 1, wherein the oxidized polysaccharide containing aldehyde groups and amine groups is oxidized diethylaminoethyl dextran or oxidized aminated dextran and the multi-arm amine is a multi-arm polyethylene glycol amine. 9. A dried hydrogel product formed by a process comprising the steps of: a) reacting in a solvent (i) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehydes group of about 90 to about 1500 Daltons and an amine substitution level of about 5% to about 50%; with (ii) at least one water-dispersible, multi-arm amine wherein at least three of the arms are terminated by a primary amine group, wherein the multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons to form a hydrogel; and b) treating the hydrogel to remove at least a portion of said solvent to form the dried hydrogel. 10. The dried hydrogel according to claim 9, wherein said dried hydrogel is a film. 11. The dried hydrogel according to claim 9, wherein the process further comprises the step of comminuting the dried hydrogel to form finely divided particles. 12. A composition for coating an anatomical site, the composition comprising the reaction product of: a) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons and an amine substitution level of about 5% to about 50%; andb) at least one water-dispersible, multi-arm amine wherein at least three of the arms are terminated by a primary amine group, wherein the multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons. 13. A composition for bonding at least two anatomical sites together, the composition comprising the reaction product of: a) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons and an amine substitution level of about 5% to about 50%; andb) at least one water-dispersible, multi-arm amine wherein at least three of the arms are terminated by a primary amine group, wherein the multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons. 14. A product for coating an anatomical site, the product comprising the dried hydrogel of claim 9. 15. A method for applying a coating to an anatomical site on tissue of a living organism, the method comprising applying to the site: a) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons and an amine substitution level of about 5% to about 50%; followed byb) at least one water-dispersible, multi-arm amine wherein at least three of the arms are terminated by a primary amine group, wherein the multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons; or applying (b) followed by (a); andmixing (a) and (b) on the site; orpremixing (a) and (b) and applying the resulting mixture to the site; orapplying (a) and (b) simultaneously to the site. 16. The method according to claim 15 wherein the oxidized polysaccharide is in the form of a first aqueous solution or dispersion and the multi-arm amine is in the form of a second aqueous solution or dispersion. 17. The method according to claim 15 wherein the oxidized polysaccharide and the multi-arm amine are in the form of finely divided powders. 18. The method according to claim 15 wherein the oxidized polysaccharide is diethylaminoethyl dextran or aminated dextran and the multi-arm amine is a multi-arm polyethylene glycol amine. 19. A method for bonding at least two anatomical sites together comprising applying to at least one of the at least two anatomical sites: a) at least one oxidized polysaccharide containing aldehyde groups and amine groups, wherein said amine groups are not primary amine groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons and an amine substitution level of about 5% to about 50%; followed byb) at least one water-dispersible, multi-arm amine wherein at least three of the arms are terminated by a primary amine group, wherein the multi-arm amine has a number-average molecular weight of about 450 to about 200,000 Daltons; or applying (b) followed by (a); andmixing (a) and (b) on the at least one site; orpremixing (a) and (b) and applying the resulting mixture to the at least one site; orapplying (a) and (b) simultaneously to the at least one site; andcontacting the at least two anatomical sites together. 20. The method according to claim 19 wherein the oxidized polysaccharide is in the form of a first aqueous solution or dispersion and the multi-arm amine is in the form of a second aqueous solution or dispersion. 21. The method according to claim 19 wherein the oxidized polysaccharide and the multi-arm amine are in the form of finely divided powders. 22. The method according to claim 19 wherein the oxidized polysaccharide is diethylaminoethyl dextran or aminated dextran and the multi-arm amine is a multi-arm polyethylene glycol amine. 23. A method for applying a coating to an anatomical site on tissue of a living organism comprising applying to the site the dried hydrogel of claim 9. 24. The method according to claim 23 wherein said dried hydrogel is in the form of a film. 25. The method according to claim 23 wherein said dried hydrogel is in the form of finely divided particles.
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