초록 ▼

The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecu

The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation.

대표청구항 ▼

1. A storage unit having a plurality of compartments, each compartment having a physical size sufficient for holding an elutable porous or semi-porous elastomeric substrate, andan elutable porous or semi-porous elastomeric substrate comprised in a compartment, wherein said elutable porous or semi-po

1. A storage unit having a plurality of compartments, each compartment having a physical size sufficient for holding an elutable porous or semi-porous elastomeric substrate, andan elutable porous or semi-porous elastomeric substrate comprised in a compartment, wherein said elutable porous or semi-porous elastomeric substrate comprises a material selected from the group consisting of polyester, polystyrene, polyurethane, and polyvinyl alcohol (PVA), andwherein a peptide or a nucleic acid is absorbed to said elutable porous or semi-porous elastomeric substrate. 2. The storage unit of claim 1, further comprising instructions for eluting or recovering an absorbed peptide or absorbed nucleic acid from the elutable porous or semi-porous elastomeric substrate. 3. The storage unit of claim 1, further comprising instructions for preparing an aqueous liquid for eluting or recovering an absorbed peptide or absorbed nucleic acid from the elutable porous or semi-porous elastomeric substrate. 4. The storage unit of claim 1, wherein each of said plurality of compartments is a well in a multi-well plate. 5. The storage unit of claim 1, wherein the peptide or the nucleic acid absorbed to the porous or semi-porous elastomeric substrate has higher resistance to degradation than a peptide or a nucleic acid not absorbed to the porous or semi-porous elastomeric substrate. 6. The storage unit of claim 1, wherein the porous or semi-porous elastomeric substrate comprising the peptide or the nucleic acid absorbed thereto contains less than 25% water by mass relative to the total mass of the absorbed substrate. 7. The storage unit of claim 1, wherein at least 30% of the peptide or the nucleic acid absorbed to the porous or semi-porous elastomeric substrate is recoverable from the substrate. 8. The storage unit of claim 1, wherein the porous or semi-porous elastomeric substrate is a foam or a sponge. 9. The storage unit of claim 1, wherein the material comprising the porous or semi-porous elastomeric substrate is reversibly compressible to at least ½ of the volume of the material in a non-compressed state. 10. The storage unit of claim 1, wherein the material comprising the porous or semi-porous elastomeric substrate is reversibly expandable to at least 2-fold the volume of the material in a non-expanded state. 11. The storage unit of claim 1, wherein the porous or semi-porous elastomeric substrate further comprises a substance selected from the group consisting of buffers, chelating agents, denaturing agents, detergents, reducing agents, antioxidants, preservatives, stabilizing agents, protease inhibitors, nuclease inhibitors, anti-microbials, and low-water uptake saccharides.