IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0947819
(2010-11-16)
|
등록번호 |
US-8435306
(2013-05-07)
|
발명자
/ 주소 |
- Evans, Douglas G
- Goldman, Scott M.
- Kronengold, Russell T.
|
출원인 / 주소 |
- Kensey Nash BVF Technology LLC
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
8 인용 특허 :
132 |
초록
An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.
대표청구항
▼
1. An implant for the repair or regeneration of an internal tissue in a living being, said implant comprising a tissue conductive matrix, with said matrix comprising a blend of soluble collagen and native collagen fibers, wherein at least a portion of said implant is porous, and further wherein said
1. An implant for the repair or regeneration of an internal tissue in a living being, said implant comprising a tissue conductive matrix, with said matrix comprising a blend of soluble collagen and native collagen fibers, wherein at least a portion of said implant is porous, and further wherein said porous portion has a pore size that is at least about 100 microns, wherein said matrix further comprises at least one of cells and cellular components seeded in said implant, and still further wherein said implant is arranged to be implanted in the body of said living being, wherein said tissue conductive matrix serves as a cartilage tissue substitute or a bone tissue substitute. 2. The implant of claim 1, wherein said internal tissue in a living being comprises cartilage tissue. 3. The implant of claim 1, wherein said cells or cellular components comprise at least one of platelet rich plasma (PRP), blood cells, cartilage cells, fat cells, genetic material, lipo-proteins, stem cells, progenitor cells, bone marrow, and combinations thereof. 4. The implant of claim 1, wherein said cells or cellular components are one of synthetic, autologous or allograft in origin. 5. The implant of claim 1, wherein said cells or cellular components are cultured for a period of time prior to implantation. 6. The implant of claim 5, wherein said period of time ranges from days to weeks. 7. The implant of claim 5 wherein at least a portion of said tissue conductive matrix exhibits elastic recovery after being compressed. 8. The implant of claim 7, wherein said tissue conductive matrix further comprises at least one ceramic. 9. The implant of claim 1, wherein at least a portion of said tissue conductive matrix exhibits elastic recovery after being compressed. 10. The implant of claim 1, wherein said matrix further comprises at least one drug or biologically active agent. 11. The implant of claim 10, wherein said biologically active agent is selected from the group consisting of cytokines, growth factors, glycosaminoglycans, proteoglycans, hormones, anti-biotics, amino acids, glycoproteins, lipids, viruses, and combinations thereof. 12. The implant of claim 10, wherein said biologically active agent is one of Adenovirus, Anti-growth factors, Anti-inflammatory agents, fibroblast growth factor (FGF), Bone morphogenic proteins (BMP), platelet-derived growth factor (PDGF), transforming growth factors (TGF), Bone marrow cells, Blood cells, Stem Cells, Fat cells, Bone cells, Cartilage cells, Cytokines, Glycosaminoglycans, metals and combinations thereof. 13. The implant of claim 1, wherein said matrix further comprises at least one additional polymer. 14. The implant of claim 13, wherein said implant is in the form of a composite structure characterized by bonded materials. 15. The implant of claim 13, wherein said additional polymer is synthetic. 16. The implant of claim 13, wherein said additional polymer is at least partially bio-resorbable. 17. The implant of claim 16, wherein said additional polymer comprises chitin, chitosan, PGA/PLLA copolymers, hydrogel, Lactide/caprolactone copolymers, PGA, PLA, PCL, tyrosine based polymers, cellulose, polyamino acids, polyurethane, polyvinyl alcohol, trimethyl carbonate, alginate, collagen, or fibrin. 18. The implant of claim 13, wherein said additional polymer is osteoconductive. 19. The implant of claim 18, wherein said osteoconductive polymer further comprises at least one ceramic. 20. The implant of claim 18, wherein said additional polymer further comprises a filler material selected from the group consisting of: calcium phosphate, calcium sulfate, hydroxyapatite, glass, monetite, brushite, metals, metal oxides, fibrin, silk, thrombin, gold, demineralized bone, and combinations thereof. 21. The implant of claim 19, wherein said at least one ceramic is in the form of particles blended with said polymer. 22. The implant of claim 1, wherein said matrix further comprises reconstituted collagen. 23. The implant of claim 1, wherein said tissue conductive matrix is bio-matched. 24. The implant of claim 23, wherein said bio-matched, tissue conductive matrix comprises a matrix that is at least one of integrity matched, porosity matched, compliance matched or weight matched. 25. The implant of claim 1, wherein at least a portion of said tissue conductive matrix exhibits elastic recovery after being compressed. 26. The implant of claim 1, wherein said pores make up more than 50 percent by volume of said porous portion. 27. An implant for the repair or regeneration of an internal tissue of a living being, said implant comprising a tissue conductive matrix comprising a blend of soluble collagen and native collagen fibers, wherein at least a portion of said implant is porous, wherein said matrix further comprises at least one of cells and cellular components seeded in said implant, and further wherein said implant being in a form selected from the group consisting of a sponge and a loose, fibrous material, and still further wherein said implant is arranged to be implanted in the body of said living being, wherein said tissue conductive matrix serves as a cartilage tissue substitute or a bone tissue substitute.
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