IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0345998
(2008-12-30)
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등록번호 |
US-8436156
(2013-05-07)
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발명자
/ 주소 |
- Kerr, John
- Jansen, Robert
- Leinhos, Duane A.
- Wiley, Jr., James Edwin
- Camborieux, Sebastien
- Baiada, Anthony
- Walker, Gordon
- Maffezzoni, Carlo
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출원인 / 주소 |
- Tate & Lyle Technology Limited
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
49 |
초록
▼
The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the gro
The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose;(ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream;(iii) removal of the precipitated salts from the product stream of (ii); and(iv) isolation of sucralose from the product stream of (iii).
대표청구항
▼
1. A method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle, said feed stream comprising a sucralose-6-acylate, the reaction vehicle, water, and salts, said salts including one or more selected from the group consisting of alkal
1. A method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle, said feed stream comprising a sucralose-6-acylate, the reaction vehicle, water, and salts, said salts including one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride, wherein said method comprises: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose;(ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) to produce a product stream including a liquid phase and precipitated salts;(iii) removal of the precipitated salts from the product stream of (ii); and(iv) isolation of sucralose from the product stream of (iii). 2. The method according to claim 1, wherein the remaining reaction vehicle is at least partially removed from the product stream of (iii), and isolation of sucralose takes place from the resulting product stream. 3. The method according to claim 2, wherein the removal of reaction vehicle from the product stream of (iii) is performed by steam stripping, or by use of an agitated thin film drier or spray drier. 4. The method according to claim 1, wherein the removal of water and, optionally, reaction vehicle from the product stream of (i) is performed by evaporation. 5. The method according to claim 4, wherein the removal of water and, optionally, reaction vehicle from the product stream of (i) is performed in a flash vessel. 6. The method according to claim 1, wherein the precipitated salts are removed by filtration. 7. The method according to claim 6, wherein the filtration is performed using a rotary vacuum filtration apparatus, a pressure filter apparatus, or a gravity filter apparatus. 8. The method according to claim 1, wherein the precipitated salts are removed by a non-filtration technique. 9. The method according to claim 8, wherein the precipitated salts are removed by a centrifuge, a cyclone, or by decantation. 10. The method according to claim 1, wherein the precipitated salts are washed with a washing solvent, and the resulting washing liquor is combined with the product stream of (iii). 11. The method according to claim 10, wherein the washing solvent is the same as the reaction vehicle. 12. The method according to claim 10, wherein the washing solvent is water. 13. The method according to claim 10, wherein the washing solvent is a brine solution. 14. The method according to claim 13, wherein the brine solution is saturated. 15. The method according to claim 1, wherein the sucralose-6-acylate is sucralose-6-benzoate or sucralose-6-acetate. 16. The method according to claim 15, wherein the sucralose-6-acylate is sucralose-6-acetate. 17. The method according to claim 1, wherein the salts consist essentially of sodium chloride. 18. The method according to claim 1, wherein the base used in the deacylation is ammonium hydroxide or a metal hydroxide. 19. The method according to claim 18, wherein said base is an alkali or alkaline earth metal hydroxide. 20. The method according to claim 19, wherein said base is an alkali metal hydroxide. 21. The method according to claim 20, wherein said base is sodium hydroxide. 22. The method according to claim 1, wherein said deacylation is carried out at a pH of from 8 to 14 and a temperature of from 0 to 60° C. 23. The method according to claim 22, wherein said deacylation is carried out at a pH of from 10 to 12 and a temperature of from 0 to 40° C. 24. The method according to claim 1, wherein the reaction vehicle is a tertiary amide. 25. The method according to claim 24, wherein the tertiary amide is dimethyl formamide (DMF). 26. The method according to claim 1, wherein the method further comprises contacting the product stream with an ion exchange resin after the removal of precipitated salts. 27. The method according to claim 26, wherein the ion exchange resin is a cation exchange resin. 28. The method according to claim 27, wherein a strong cation exchange resin is used as the cation exchange resin, and wherein the strong cation exchange resin contains a sulfonate group or other acidic group. 29. The method according to claim 28, wherein Purolite® C120E or Dowex® HCRS is used as the cation exchange resin. 30. The method according to claim 26, wherein the contacting of the product stream with the ion exchange resin takes place after remaining reaction vehicle has at least partially been removed from the product stream. 31. The method according to claim 26, wherein the product stream is essentially aqueous when contacted with the ion exchange resin. 32. The method according to claim 26, wherein the product stream is filtered prior to being contacted with the ion exchange resin. 33. The method according to claim 26, wherein the ion exchange resin is flushed with a flushing solvent after it has been contacted with the product stream, and wherein the flushing liquor thereby obtained is combined with the downstream product stream. 34. The method according to claim 33, wherein the flushing solvent is deionised water. 35. The method according to claim 26, wherein the ion exchange resin is treated with a regenerant after it has been contacted with the product stream. 36. The method according to claim 35, wherein the regenerant is selected from the group consisting of an aqueous sodium chloride solution or an aqueous sodium hydroxide solution. 37. The method according to claim 35, wherein the regenerant is subsequently collected. 38. The method according to claim 37, wherein the collected regenerant comprises dimethyl amine (DMA). 39. The method according to claim 38, wherein the DMA is subjected to reaction conditions effective to convert DMA into DMF. 40. The method according to claim 35, wherein the ion exchange resin is re-used after having been treated with the regenerant. 41. The method according to claim 26, wherein the precipitated salts are washed with a washing solvent, and the resulting washing liquor is combined with the product stream downstream of its being contacted with an ion exchange resin.
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