IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0409951
(2009-03-24)
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등록번호 |
US-8436157
(2013-05-07)
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발명자
/ 주소 |
- Wiley, Jr., James Edwin
- Leinhos, Duane A.
- Dentel, David A.
- Kerr, John
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출원인 / 주소 |
- Tate & Lyle Technology Limited
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
49 |
초록
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The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate;(ii) qu
The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate;(ii) quenching the product stream of (i) with an aqueous solution of a base to provide a sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate;(iii) either: deacylating the sucralose-6-acylate by treating the product stream of (ii) with a base and thereafter removing precipitated salt to provide a product stream including sucralose;or:removing precipitated salt from the product stream of (ii) and thereafter deacylating the sucralose-6-acylate by treating with a base to provide a product stream including sucralose; and(iv) isolating sucralose from the product stream of (iii).
대표청구항
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1. A method for producing sucralose from a feed stream comprising a sucrose-6-acylate in a reaction vehicle, wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate;(ii) quenching the produ
1. A method for producing sucralose from a feed stream comprising a sucrose-6-acylate in a reaction vehicle, wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate;(ii) quenching the product stream of (i) with an aqueous solution of a base to provide a sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate; and(iii) either: deacylating the sucralose-6-acylate by treating the product stream of (ii) with a base and thereafter removing precipitated salt to provide a product stream comprising sucralose;or:removing precipitated salt from the product stream of (ii) and thereafter deacylating the sucralose-6-acylate by treating with a base to provide a product stream comprising sucralose. 2. A method according to claim 1, further comprising: (iv) isolating sucralose from the product stream of (iii). 3. A method according to claim 1, wherein the base used for quenching in (ii) is an alkali metal or alkaline earth metal hydroxide, or ammonium hydroxide. 4. A method according to claim 3, wherein the base used for quenching in (ii) is sodium hydroxide. 5. A method according to claim 4, wherein the sodium hydroxide is provided as an aqueous solution having a concentration of from 12% w/w to 50% w/w. 6. A method according to claim 1, wherein the pH of the stream is maintained in the range of from 7.5 to 10.5 during the quenching (ii). 7. A method according to claim 1, wherein the temperature of the stream is maintained in the range of from above 12° C. to 35° C. during the quenching (ii). 8. A method according to claim 1, wherein the pH of the stream is allowed to rise to between 10 and 12 during the quenching (ii), such that deacylation of the sucralose-6-acylate also takes place to at least some extent. 9. A method according to claim 8, wherein the temperature of the stream is maintained in the range of from 0 to 40° C. during the quenching (ii). 10. A method according to claim 1, wherein prior to the removal of precipitated salt, the stream is concentrated to at least partially remove water, and optionally also reaction vehicle, in order to cause further salt to be precipitated. 11. A method according to claim 1, wherein the precipitated salt is removed by filtration. 12. A method according to claim 1, wherein the precipitated salt is removed by a non-filtration technique. 13. A method according to claim 1, wherein the precipitated salt is washed with a washing solvent, and the resulting washing liquor is returned to the stream. 14. A method according to claim 13, wherein the washing solvent is the same as the reaction vehicle, or is selected from water, a brine solution, or a saturated brine solution. 15. A method according to claim 1, wherein the sucralose-6-acylate is sucralose-6-benzoate or sucralose-6-acetate. 16. A method according to claim 1, wherein reaction vehicle is at least partially removed from the product stream of (iii), and isolation of sucralose takes place from the resulting product stream. 17. A method according to claim 16, wherein the removal of reaction vehicle is performed by steam stripping, or by use of an agitated thin film drier or spray drier. 18. A method according to claim 1, wherein the base used for deacylating the sucralose-6-acylate in (iii) is a metal or ammonium hydroxide. 19. A method according to claim 1, wherein deacylating the sucralose-6-acylate in (iii) is carried out at a pH of from 8 to 14 and a temperature of from 0 to 60° C. 20. A method according to claim 19, wherein deacylating the sucralose-6-acylate in (iii) is carried out at a pH of from 10 to 12 and a temperature of from 0 to 40° C. 21. A method according to claim 1, wherein the reaction vehicle comprises a tertiary amide. 22. A method according to claim 21, wherein the tertiary amide is dimethyl formamide (DMF). 23. A method according to claim 1, wherein the method further comprises contacting the product stream of (iii) with an ion exchange resin. 24. A method according to claim 23, wherein the ion exchange resin is a cation exchange resin. 25. A method according to claim 24, wherein a strong cation exchange resin is used as the cation exchange resin. 26. A method according to claim 23, wherein the contacting of the product stream with the ion exchange resin takes place after reaction vehicle has at least partially been removed from the product stream. 27. A method according to claim 23, wherein the product stream is essentially aqueous when contacted with the ion exchange resin. 28. A method according to claim 23, wherein the product stream is filtered prior to being contacted with the ion exchange resin. 29. A method according to claim 23, wherein the ion exchange resin is flushed with a flushing solvent after it has been contacted with the product stream, and wherein the flushing liquor thereby obtained is combined with the downstream product stream. 30. A method according to claim 29, wherein the flushing solvent is deionised water. 31. A method according to claim 23, wherein the ion exchange resin is treated with a regenerant after it has been contacted with the product stream. 32. A method according to claim 31, wherein the regenerant is selected from the group consisting of an aqueous sodium chloride solution or an aqueous sodium hydroxide solution. 33. A method according to claim 31, wherein the regenerant is subsequently collected. 34. A method according to claim 33, wherein the collected regenerant comprises dimethyl amine (DMA). 35. A method according to claim 34, wherein the DMA is subjected to reaction conditions effective to convert DMA into DMF. 36. A method according to claim 31, wherein the ion exchange resin is re-used after having been treated with the regenerant. 37. A method according to claim 23, wherein the precipitated salts are washed with a washing solvent, and the resulting washing liquor is combined with the product stream downstream of its being contacted with an ion exchange resin. 38. A method for producing a sucralose-6-acylate product stream from a feed stream comprising a sucrose-6-acylate in a reaction vehicle, wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate;(ii) quenching the product stream of (i) with an aqueous solution of a base to provide the sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate; and(iii) removing precipitated salt from the product stream of (ii) to provide a sucralose-6-acylate product stream. 39. A method according to claim 38, further comprising isolating the sucralose-6-acylate from the product stream of (iii). 40. A method according to claim 38, further comprising the conversion of sucralose-6-acylate to sucralose to provide a sucralose product stream. 41. A method according to claim 40, further comprising isolating sucralose from the sucralose product stream.
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