[특허]Polyethylene cross-linked with an anthocyanin

Polyethylene cross-linked with an anthocyanin 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/02
출원번호	US-0623254 (2012-09-20)
등록번호	US-8439975 (2013-05-14)
발명자 / 주소	He, Shulin Yau, Shi-Shen Wang, Aiguo Lawrynowicz, Daniel E.
출원인 / 주소	Howmedica Osteonics Corp.
대리인 / 주소	Lerner, David, Littenberg, Krumholz & Mentlik, LLP
인용정보	피인용 횟수 : 0 인용 특허 : 26

초록 ▼

A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to γ ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is then evaporated to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.

대표청구항 ▼

1. A method of making cross-linked ultra-high molecular weight polyethylene material comprising: combining a solution of anthocyanin material and ultra-high molecular weight polyethylene (UHMWPE) powder to form a doped ultra-high-molecular weight polyethylene wherein the anthocyanin is uniformly blended with the UHMWPE powder after drying; andconsolidating the doped powder to form a material having a color from light pink to deep red. 2. The method as set forth in claim 1 wherein the concentration of anthocyanin is between 0.005 and 5% by weight. 3. The method as set forth in claim 2 wherein a pink color is produced by a concentration of 0.005 by weight. 4. The method as set forth in claim 2 wherein the anthocyanin and the UHMWPE powder is blended in a blender prior to drying. 5. The method as set forth in claim 1 wherein the blend is dried under nitrogen. 6. The method of claim 1 further comprising the step of irradiating the consolidated doped UHMWPE and heating the doped UHMWPE after irradiating. 7. The method of claim 6 further comprising the step of forming the irradiated and heated doped ultra-high molecular weight polyethylene into an orthopedic bearing component. 8. The method of claim 6 further comprising the step of sterilizing the consolidated doped UHMWPE during or subsequent to irradiating. 9. The method of claim 8 wherein the sterilizing step comprises contacting the implant with electron-beam radiation, gamma radiation, gas plasma or ethylene oxide. 10. The method of claim 1 wherein the ultra high molecular weight polyethylene anthocyanin blend is a substantially uniform blend. 11. A method of forming a sterilized packaged medical implant comprising: blending an ultra-high molecular weight polyethylene (UHMWPE) powder and an anthocyanin solution wherein the anthocyanin is dispersed in the UHMWPE in a concentration of between 0.05% and 5.0% w/w % to form a uniform blend having a color of light pink to deep red;consolidated the blended polyethylene powder;thereafter forming a medical implant; andsterilizing the formed medical implant. 12. The method of claim 11 wherein the sterilizing step comprises contacting the implant with electron-beam radiation, gamma radiation, gas plasma or ethylene oxide. 13. The method as set forth in claim 11 further comprising irradiating and heating the consolidated blended polyethylene powder. 14. A method of making ultra high molecular weight polyethylene (UHMWPE) material comprising: mixing a power or granulate of UHMW polyethylene with an aqueous liquid that contains anthocyanin in a concentration of between 0.002% and 5.0% by weight, the liquid having a color from light pink to deep red;evaporating the aqueous liquid in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles;compressing the coated polyethylene particles into blocks or rods at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 Mpa andsequentially irradiating the blocks or rods at a dose of 2-5 Mrads for a total dose of 9-12 Mrads followed by heating below the melting point followed by cooling after each irradiation to produce a material having a color of light pink to red. 15. The method as set forth in claim 14 wherein the aqueous liquid comprises deionized water. 16. The method as set forth in claim 14 further comprising forming the material into medical implants. 17. The method as set forth in claim 14 wherein the anthocyanin is obtained from grapes or bilberries.

이 특허에 인용된 특허 (26)

Simmons,Eugene R.; Bunnelle,William L.; Malcolm,David B.; Knutson,Keith C.; Kauffman,Thomas F.; Kroll,Mark S.; Keehr,Michael S.; Parikh,Deepak R.; Allen,Jimmy D.; Speth,David R.; Yalvac,Selim; Finlay, Adhesives comprising olefin polymers.
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Muratoglu,Orhun K.; Spiegelberg,Stephen H.; McKinley,Gareth H., High modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt.
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Lee ; Jr. Henry L. (3534 E. California Blvd. Pasadena CA 91107) Orlowski Jan A. (1304 Rubio Dr. Altadena CA 91001) Kidd Patrick D. (415 N. Lina St. Sierra Madre CA 91024), Liquid paint-on dental restorative process and composition.
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Hahn David, Medical implant composition.
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Gray James Ian ; Booren Alden M. ; Nair Muraleedharan G. ; Strasburg Gale M. ; Wang Haibo ; Gomaa Enayat A. ; Chang Yu-Chen, Method and compositions for inhibiting oxidation.
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Lars Lidgren SE; Peter Bengtsson SE; Peter Sj{overscore (o)}vall SE; Bengt Wesslen SE, Method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof.
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Muratoglu,Orhun K.; Spiegelberg,Stephen H., Methods for making oxidation resistant polymeric material.
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Muratoglu,Orhun K.; Spiegelberg,Stephen H., Methods for making oxidation resistant polymeric material.
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Sun Deh-Chuan (Rockaway NJ) Stark Casper F. (Pompton Lakes NJ), Non-oxidizing polymeric medical implant.
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Sun, Deh-Chuan; Stark, Casper F., Non-oxidizing polymeric medical implant.
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King,Richard S.; Hanes,Mark D., Polymer composition comprising cross-linked polyethylene and methods for making the same.
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Pratt Clyde ; Carignan Roger, Process for applying suction to bone drilling and reaming operations.
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Saum Kenneth Ashley ; Sanford William Michael ; DiMaio ; Jr. William Gerald ; Howard ; Jr. Edward George, Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance.
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Vunsh Ron (Hamerkaz ILX) Matilsky Michael B. (Mevasseret Zion ILX), Production and use of a high-intensity red natural colorant derived from carrot cell tissue cultures.
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Jin,Shuhua; Jia,Weitao, Self-curing system for endodontic sealant applications.
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