초록 ▼

A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to prevent anastomosis of a surgical wound in the digestive system of a patient, and for affixing prosthe

A biological adhesive formulation comprising dextrin, at least one adhesiveness modifier agent, and at least one antibiotic is suitable for promoting healing of tissue in a patient, for example, to prevent anastomosis of a surgical wound in the digestive system of a patient, and for affixing prosthesis during a hernia operation in a patient and occluding a fistula within a patient.

대표청구항 ▼

1. A method for promoting healing of tissue in a patient comprising applying to said tissue an adhesive formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulat

1. A method for promoting healing of tissue in a patient comprising applying to said tissue an adhesive formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and optionally at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, and said dextrin dispersion contains 45-75 weight % solids, based on the total weight of the formulation, wherein said formulation has a viscosity of 12,000-25,000 cp, wherein said formulation protects and seals anastomosis and suture lines in internal body cavities, and having a resistance to humidity to provide temporary protection of the anastomosis from at least the 2nd to the 14th post-operative days. 2. A method for preventing dehiscence of an anastomosis or of a surgical wound in a patient, comprising applying to said anastomosis or surgical wound an adhesive formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and optionally at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, and said dextrin dispersion contains 45-75 weight % solids, based on the total weight of the formulation, wherein said formulation has a viscosity of 12,000-25,000 cp, wherein said formulation protects and seals anastomosis and suture lines in internal body cavities, and having a resistance to humidity to provide temporary protection of the anastomosis from at least the 2nd to the 14th post-operative days. 3. A method according to claim 2, wherein said surgical wound is within the digestive system and said adhesive formulation protects against dehiscences of anastomosis of the digestive system. 4. A method of affixing a prosthesis during a hernia operation in a patient, comprising applying to said prosthesis an adhesive formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and optionally at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, and said dextrin dispersion contains 45-75 weight % solids, based on the total weight of the formulation, wherein said formulation has a viscosity of 12,000-25,000 cp. 5. A method according to claim 4, wherein said hernia operation is for an inguinal hernia. 6. A method for occluding a fistula within a patient comprising applying to said fistula an adhesive formulation comprising dextrin as a dispersion, at least one adhesiveness modifier agent comprising from 8 weight % to about 19 weight % zinc oxide powder based on the total weight of the formulation, and optionally at least one antibiotic, wherein said formulation contains 80-97 weight % of said dextrin dispersion, and said dextrin dispersion contains 45-75 weight % solids, based on the total weight of the formulation, wherein said formulation has a viscosity of 12,000-25,000 cp.