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Single molecule arrays for genetic and chemical analysis

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12P-019/34
  • C12M-001/36
  • C07H-021/04
출원번호 US-0982467 (2007-10-31)
등록번호 US-8445197 (2013-05-21)
발명자 / 주소
  • Drmanac, Radoje
  • Callow, Matthew J.
  • Drmanac, Snezana
  • Hauser, Brian K.
  • Yeung, George
출원인 / 주소
  • Callida Genomics, Inc.
대리인 / 주소
    Kilpatrick Townsend & Stockton LLP
인용정보 피인용 횟수 : 11  인용 특허 : 96

초록

Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discre

대표청구항

1. A method of identifying a sequence of a target polynucleotide, said method comprising: (a) providing a substrate comprising a plurality of discrete regions,wherein a majority of said plurality of discrete regions comprises a single concatemer comprising a plurality of monomeric units,wherein each

이 특허에 인용된 특허 (96)

  1. Barany, Francis; Liu, Jianzhao; Kirk, Brian W.; Zirvi, Monib; Gerry, Norman P.; Paty, Philip B., Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing.
  2. DuBridge Robert B. ; Albrecht Glenn ; Brenner Sydney,GBX ; Gryaznov Sergei M. ; McCurdy Sarah N., Adaptor-based sequence analysis.
  3. Auerbach Jeffrey I., Amplification of nucleic acid molecules via circular replicons.
  4. Birkenmeyer Larry G. (Chicago IL) Carrino John J. (Gurnee IL) Dille Bruce J. (Antioch IL) Hu Hsiang-Yun (Libertyville IL) Kratochvil Jon D. (Kenosha WI) Laffler Thomas G. (Libertyville IL) Marshall R, Amplification of target nucleic acids using gap filling ligase chain reaction.
  5. Ulmer,Kevin, Apparatus and methods for analyzing samples.
  6. Balasubramanian, Shankar; Klenerman, David; Bentley, David, Arrayed biomolecules and their use in sequencing.
  7. Fodor Stephen P.A. ; Stryer Lubert ; Read J. Leighton ; Pirrung Michael C., Arrays of materials attached to a substrate.
  8. Chee Mark ; Cronin Maureen T. ; Fodor Stephen P. A. ; Huang Xiaohua X. ; Hubbell Earl A. ; Lipshutz Robert J. ; Lobban Peter E. ; Morris MacDonald S. ; Sheldon Edward L., Arrays of nucleic acid probes on biological chips.
  9. Sapolsky Ronald J. ; Lipshutz Robert J. ; Gingeras Thomas R., Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping.
  10. Koch, J.o slashed.rn Erland, Cascade nucleic acid amplification reaction.
  11. Pachuk Catherine J. ; Samuel Manoj ; Satishchandran C., Chain reaction cloning using a bridging oligonucleotide and DNA ligase.
  12. Kool Eric T., Circular DNA vectors for synthesis of RNA and DNA.
  13. Landegren Ulf,SEX ; Kwiatkowski Marek,SEX, Circularizing nucleic acid probe able to interlock with a target sequence through catenation.
  14. Chee, Mark; Walt, David R., Combinatorial decoding of random nucleic acid arrays.
  15. Stuelpnagel, John R.; Chee, Mark S., Compositions and methods for repetitive use of genomic DNA.
  16. Gryaznov Sergei M. (San Mateo CA), Convergent synthesis of branched and multiply connected macromomolecular structures.
  17. Macevicz Stephen C., DNA sequencing by parallel oligonucleotide extensions.
  18. Whiteley Norman M. (San Carlos CA) Hunkapiller Michael W. (San Carlos CA) Glazer Alexander N. (Orinda CA), Detection of specific sequences in nucleic acids.
  19. Drmanac, Radoje; Drmanac, Snezana; Kita, David; Cooke, Cory; Xu, Chongjun, Enhanced sequencing by hybridization using pools of probes.
  20. Macevicz Stephen C., Gene expression analysis.
  21. Kool Eric T., Highly sensitive multimeric nucleic acid probes.
  22. Carl T. Wittwer ; Mark G. Herrmann, Homogeneous multiplex hybridization analysis by color and Tm.
  23. Auerbach Jeffrey I., In vitro amplification of nucleic acid molecules via circular replicons.
  24. Deugau Kenneth V. (Kingston CAX) Unrau Paul (Deep River CAX), Indexing linkers.
  25. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof.
  26. Albrecht Glenn ; Brenner Sydney,GBX ; DuBridge Robert B. ; Lloyd David H. ; Pallas Michael C., Massively parallel signature sequencing by ligation of encoded adaptors.
  27. Brennan Thomas M., Method and apparatus for conducting an array of chemical reactions on a support surface.
  28. Brennan Thomas M. (San Francisco CA), Method and apparatus for conducting an array of chemical reactions on a support surface.
  29. Butler, John H.; Brennan, Thomas M., Method and apparatus for in situ synthesis on a solid support.
  30. Henderson, Eric; Mosher, Curtis; Lynch, Michael P., Method and apparatus for solid state molecular analysis.
  31. Henderson,Eric; Mosher,Curtis; Lynch,Michael P., Method and apparatus for solid state molecular analysis.
  32. Fire Andrew (Baltimore MD) Xu Si-Qun (Baltimore MD), Method for constructing an oligonucleotide concatamer library by rolling circle replication.
  33. Adams Christopher P. (Winter Hill MA) Kron Stephen Joseph (Boston MA), Method for performing amplification of nucleic acid with two primers bound to a single solid support.
  34. Fodor Stephen P.A. ; Solas Dennis W. ; Dower William J., Method of detecting nucleic acids.
  35. Brenner, Sydney, Method of screening for genetic polymorphism.
  36. Nyren P.ang.l,SEX ; Uhlen Mathias,SEX ; Ronaghi Mostafa,SEX, Method of sequencing DNA.
  37. Rothberg Jonathan M. ; Bader Joel S., Method of sequencing a nucleic acid.
  38. Rothberg,Jonathan M.; Bader,Joel S.; Dewell,Scott B.; McDade,Keith; Simpson,John W.; Berka,Jan; Colangelo,Christopher M., Method of sequencing a nucleic acid.
  39. Rothberg,Jonathan M.; Bader,Joel S.; Dewell,Scott B.; McDade,Keith; Simpson,John W.; Berka,Jan; Colangelo,Christopher M., Method of sequencing a nucleic acid.
  40. Drmanac Radoje T. (Belgrade YUX) Crkvenjakov Radomir B. (Belgrade YUX), Method of sequencing by hybridization of oligonucleotide probes.
  41. Drmanac Radoje T. (Zvecanska 46 Beograd 11000) Crkvenjakov Radomir B. (Bulevar JNA 118 Beograd YUX 11000), Method of sequencing of genomes by hybridization of oligonucleotide probes.
  42. Schon Eric A., Method to detect mutations in a nucleic acid using a hybridization-ligation procedure.
  43. Drmanac Radoje, Methods and apparatus for DNA sequencing and DNA identification.
  44. Brennan Thomas M. (2000 Broadway ; No. 705 San Francisco CA 94115) Heyneker Herbert L. (360 Forest Ave. ; No. 506 Palo Alto CA 94301), Methods and compositions for determining the sequence of nucleic acids.
  45. Radoje Drmanac, Methods and compositions for efficient nucleic acid sequencing.
  46. Zailin Yu ; Zaoyuan Peng ; Qianjin Hu, Methods for amplifying and detecting multiple polynucleotides on a solid phase support.
  47. Drmanac Radoje T., Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes.
  48. Weissman, Sherman; Lasken, Roger, Methods for selectively isolating DNA using rolling circle amplification.
  49. Drmanac Radoje T. ; Drmanac Snezana ; Hou Aaron ; Hauser Brian, Methods for sequencing repetitive sequences and for determining the order of sequence subfragments.
  50. Auerbach Jeffrey I. (13109 Jasmine Hill Terr. Rockville MD 20850), Methods for the isothermal amplification of nucleic acid molecules.
  51. Kool Eric T. (Rochester NY), Methods of making single-stranded circular oligonucleotides.
  52. Yeung Anthony T., Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands.
  53. Heller Michael J. (Encinitas CA) Tu Eugene (San Diego CA) Butler William F. (Carlsbad CA), Molecular biological diagnostic systems including electrodes.
  54. Lizardi Paul M., Molecular cloning using rolling circle amplification.
  55. Iyer Rajkumar Siva ; Su Sheng-Hui ; Inamdar Anita ; Kalra Krishan L., Multifunctional linking reagents for synthesis of branched oligomers.
  56. Lizardi Paul M., Multiple displacement amplification.
  57. Fan, Jian-Bing; Stuelpnagel, John R.; Chee, Mark S., Multiplexed detection of analytes.
  58. Brenner, Sydney, Nucleic acid analysis using sequence tokens.
  59. Sabanayagam Chandran R. ; Sano Takeshi ; Misasi John ; Hatch Anson ; Cantor Charles, Nucleic acid arrays and methods of synthesis.
  60. Fan, Jian-Bing; Fu, Xiang-Dong, Nucleic acid detection methods using universal priming.
  61. Guilfoyle Richard A. ; Guo Zhen, Nucleic acid indexing.
  62. Urdea Michael S. (Alamo CA) Warner Brian (Martinez CA) Horn Thomas (Berkeley CA), Nucleic acid multimers and amplified nucleic acid hybridization assays using same.
  63. Seeman Nadrian ; Winfree Erik ; Liu Furong ; Wenzler Savin Lisa, Periodic two and three dimensional nucleic acid structures.
  64. Stephen P. A. Fodor ; Lubert Stryer ; J. Leighton Read ; Michael C. Pirrung, Polymer arrays.
  65. Lyle J. Arnold ; Samuel P. Sawan ; Paul H. Lee, Polymer coated surfaces for microarray applications.
  66. Newman Peter J. (Shorewood WI) Aster Richard H. (Milwaukee WI), Polymorphism of human platelet membrane glycoprotein IIIa and diagnostic and therapeutic applications thereof.
  67. Sibson David Ross,GBX, Process for categorizing nucleotide sequence populations.
  68. Stephen P. A. Fodor ; Dennis W. Solas ; William J. Dower, Products for detecting nucleic acids.
  69. Wang Bruce, Quantitative microarray hybridizaton assays.
  70. Qiao,Tiecheng A.; Chari,Krishnan; Vizard,Douglas L., Random array of micro-spheres for the analysis of nucleic acids.
  71. George M. Church, Replica amplification of nucleic acid arrays.
  72. Guire, Patrick E.; Swanson, Melvin J., Replicable probe array.
  73. Hunkapiller Michael W. ; Richards John H., Restriction enzyme mediated adapter.
  74. Mahtani Melanie M., Rolling circle amplification assay for nucleic acid analysis.
  75. Christian, Allen T.; Pattee, Melissa S.; Attix, Cristina M.; Tucker, James D., Rolling circle amplification detection of RNA and DNA.
  76. Kumar, Gyanendra; Abarz?a, Patricio, Rolling circle amplification of RNA.
  77. Landegren, Ulf, Rolling circle replication of padlock probes.
  78. Lizardi Paul M.,MXX, Rolling circle replication reporter systems.
  79. Paul M. Lizardi MX, Rolling circle replication reporter systems.
  80. Kool Eric T., Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides.
  81. Zabeau Marc,BEX ; Vos Pieter,NLX, Selective restriction fragment amplification: fingerprinting.
  82. Drmanac, Radoje; Callow, Matthew J.; Hauser, Brian K.; Yeung, George, Self-assembled single molecule arrays and uses thereof.
  83. Neuschafer Dieter,CHX ; Duveneck Gert Ludwig,GBX ; Pawlak Michael,GBX ; Pieles Uwe,GBX ; Budach Wolfgang,CHX, Sensor platform and method for the parallel detection of a plurality of analytes using evanescently excited luminescence.
  84. Lizardi Paul M. ; Huang Xiaohua, Single molecule analysis target-mediated ligation of bipartite primers.
  85. Barany Francis (Baltimore MD), Six base oligonucleotide linkers and methods for their use.
  86. Peponnet Christine,FRX, Solid support for solid phase amplification and sequencing and method for preparing the same nucleic acid.
  87. J. Leighton Read ; Stephen P. A. Fodor ; Lubert Stryer ; Michael C. Pirrung, Support bound probes and methods of analysis using the same.
  88. Barnes,Colin, Synthesis of spatially addressed molecular arrays.
  89. Bridgham, John; Corcoran, Kevin; Golda, George; Pallas, Michael C.; Brenner, Sydney, System and apparatus for sequential processing of analytes.
  90. Stephen P.A. Fodor ; James L. Winkler, System for determining receptor-ligand binding affinity.
  91. Rabbani,Elazar; Stavrianopoulos,Jannis G.; Kirtikar,Dollie; Johnston,Kenneth H.; Thalenfeld,Barbara E., System, array and non-porous solid support comprising fixed or immobilized nucleic acids.
  92. Egholm Michael ; Chen Caifu, Template-dependent ligation with PNA-DNA chimeric probes.
  93. Lizardi Paul M.,MXX ; Caplan Michael, Unimolecular segment amplification and sequencing.
  94. Lizardi Paul M.,MXX ; Caplan Michael, Unimolecular segment amplification and sequencing.
  95. Lizardi, Paul M., Unimolecular segment amplification and sequencing.
  96. Pirrung Michael C. ; Read J. Leighton ; Fodor Stephen P. A. ; Stryer Lubert, Very large scale immobilized polymer synthesis.

이 특허를 인용한 특허 (11)

  1. Kermani, Bahram Ghaffarzadeh; Drmanac, Radoje, Analyzing genome sequencing information to determine likelihood of co-segregating alleles on haplotypes.
  2. Oliphant, Arnold, Apparatus for high throughput sequencing of nucleic acids.
  3. Drmanac, Radoje T.; Callow, Matthew, Efficient arrays of amplified polynucleotides.
  4. Drmanac, Radoje; Callow, Matthew J.; Drmanac, Snezana; Hauser, Brian K.; Yeung, George, High density DNA array.
  5. Oliphant, Arnold, Method for high throughput screening of nucleic acids.
  6. Halpern, Aaron; Pant, Krishna, Methods for estimating genome-wide copy number variations.
  7. Drmanac, Radoje; Peters, Brock A.; Alexeev, Andrei, Multiple tagging of individual long DNA fragments.
  8. Drmanac, Radoje; Peters, Brock A.; Alexeev, Andrei, Multiple tagging of individual long DNA fragments.
  9. Kermani, Bahram Ghaffarzadeh; Drmanac, Radoje, Phasing of heterozygous loci to determine genomic haplotypes.
  10. Drmanac, Radoje; Callow, Matthew J.; Drmanac, Snezana; Hauser, Brian K.; Yeung, George, Single molecule arrays for genetic and chemical analysis.
  11. Drmanac, Radoje; Dahl, Fredrik; Hurowitz, Evan; Dahl, Fredrie, cDNA library for nucleic acid sequencing.
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