초록 ▼

The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and wa

The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.

대표청구항 ▼

1. A biocompatible, biodegradable prepolymer composition comprising: hydrophilic prepolymers and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the total number of hydrophilic and hydrophobic

1. A biocompatible, biodegradable prepolymer composition comprising: hydrophilic prepolymers and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the total number of hydrophilic and hydrophobic prepolymers have two or more ethylenically unsaturated functional groups; and water; wherein the hydrophilic prepolymers are prepared from a polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polythiols based on butanedithiol, hexanedithiol or pentaerythritol tetrakis (3-mercaptopropionate), copolymers of said polythiols, polyacrylamides, polyvinyl pyrolidone, polyhydroxyethyl methacrylate or block, graft or random copolymers thereof; andwherein the hydrophobic prepolymers are prepared from di or higher hydroxyl or amine functionalized oligomers based on esters, carbonates, anhydrides, orthoesters, lactones, phosphazenes. 2. The biocompatible, biodegradable prepolymer composition of claim 1 wherein at least 25% of the total number of hydrophilic and hydrophobic prepolymers have two or more ethylenically unsaturated functional groups. 3. The biocompatible, biodegradable prepolymer composition of claim 1 wherein at least 40% of the total number of hydrophilic and hydrophobic prepolymers have two or more ethylenically unsaturated functional groups. 4. The biocompatible, biodegradable prepolymer composition of claim 1 wherein the hydrophilic prepolymers contain at least one functional group selected from the group consisting of thiol or hydroxyl and the hydrophobic prepolymers contain at least one functional group selected from the group consisting of hydroxyl, or amine. 5. The biocompatible, biodegradable prepolymer composition of claim 1 wherein the hydrophilic prepolymers or hydrophobic prepolymers contain at least one urethane/urea linkage formed by reaction of isocyanate with polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polythiols based on butanedithiol, hexanedithiol or pentaerythritol tetrakis (3-mercaptopropionate), copolymers of said polythiols , polyacrylamides, polyvinyl pyrolidone, polyhydroxyethyl methacrylate or block, graft or random copolymers thereof or formed by reaction of isocyanate with di or higher hydroxyl or amine functionalized oligomers based on esters, carbonates, anhydrides, orthoesters, lactones, phosphazenes. 6. The biocompatible, biodegradable prepolymer composition of claim 1 which is soluble, miscible or forms an emulsion or paste when mixed with additional water. 7. A biocompatible, biodegradable polymer composition which is the reaction product of: hydrophilic prepolymers and hydrophobic prepolymers, wherein at least one hydrophobic prepolymer has at least one ethylenically unsaturated functional group and at least 5% of the total number of hydrophilic and hydrophobic prepolymers have two or more ethylenically unsaturated functional groups; and water; wherein the hydrophilic prepolymers are prepared from polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polythiols based on butanedithiol, hexanedithiol or pentaerythritol tetrakis (3-mercaptopropionate) or copolymers of said polythiols thereof, polyacrylamides, polyvinyl pyrolidone and polyhydroxyethyl methacrylate or block, graft or random copolymers thereof; andwherein the hydrophobic prepolymers are prepared from di or higher hydroxyl or amine functionalized oligomers based on esters, carbonates, anhydrides, orthoesters, lactones, phosphazenes. 8. The biocompatible, biodegradable polymer composition of claim 7 wherein at least 25% of the total number of hydrophilic and hydrophobic prepolymers have two or more ethylenically unsaturated functional groups. 9. The biocompatible, biodegradable polymer composition of claim 7 wherein at least 40% of the total number of hydrophilic and hydrophobic prepolymers have two or more ethylenically unsaturated functional groups. 10. The biocompatible, biodegradable polymer composition of claim 7 wherein the hydrophilic prepolymers contain at least one functional group selected from the group consisting of thiol or carboxyl and the hydrophobic prepolymers contain at least one functional group selected from the group consisting of hydroxyl, or amine. 11. A cured biocompatible, biodegradable polymer comprising the reaction product of the polymer composition according to claim 7 and at least one initiator. 12. A biocompatible, biodegradable scaffold comprising the reaction product of the polymer composition according to claim 7 and at least one initiator. 13. The biocompatible, biodegradable polymer composition of claim 7 wherein the urethane/urea linkage formed by reaction of isocyanate with polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polythiols based on butanedithiol, hexanedithiol or pentaerythritol tetrakis (3-mercaptopropionate), copolymers of said polythiols, polyacrylamides, polyvinyl pyrolidone, polyhydroxyethyl methacrylate or block, graft or random copolymers thereof or formed by reaction of isocyanate with di or higher hydroxyl or amine functionalized oligomers based on esters, carbonates, anhydrides, orthoesters, lactones, phosphazenes. 14. The biocompatible, biodegradable polymer composition of claim 7 which is soluble, miscible or forms an emulsion or paste when mixed with additional water.