IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0453771
(2012-04-23)
|
등록번호 |
US-8455009
(2013-06-04)
|
발명자
/ 주소 |
- Tseng, Scheffer
- He, Hua
- Li, Wei
|
출원인 / 주소 |
|
대리인 / 주소 |
Wilson, Sonsini, Goodrich & Rosati
|
인용정보 |
피인용 횟수 :
22 인용 특허 :
58 |
초록
▼
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtai
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
대표청구항
▼
1. A method for reducing inflammation in a subject in need thereof comprising, administering to the subject a composition comprising: pulverized or ground amniotic membrane (AM) preparation isolated from placenta that is frozen or previously frozen;wherein inflammation is reduced. 2. The method of c
1. A method for reducing inflammation in a subject in need thereof comprising, administering to the subject a composition comprising: pulverized or ground amniotic membrane (AM) preparation isolated from placenta that is frozen or previously frozen;wherein inflammation is reduced. 2. The method of claim 1, wherein the composition is formulated as a non-solid dosage form. 3. The method of claim 1, wherein the composition is formulated as a solution, drops, suspension, aerosol, paste, spray, ointment, oil, emulsion, cream, lotion, gel, a coated bandage, a patch, sticks, balms, shampoo, or combination thereof. 4. The method of claim 1, wherein the composition is formulated for ophthalmic administration. 5. The method of claim 1, wherein the composition is formulated for intraocular injection, subretinal injection, intravitreal injection, periocular injection, subconjuctival injection, retrobulbar injection, intracameral injection, sub-Tenon's injection, implantation, ocular implantation, ocular insertion. 6. The method of claim 1, wherein the composition is formulated for topical administration. 7. The method of claim 1, wherein the composition further comprises a penetration enhancer and an aqueous adjuvant. 8. The method of claim 1, wherein the composition is formulated for systemic administration. 9. The method of claim 1, wherein the composition is formulated as a solid dosage form. 10. The method of claim 1, wherein the composition is formulated as a solid dosage form, and wherein the solid dosage form is for inserting between an eye and an eyelid, or in a conjunctival sac. 11. The method of claim 1, wherein the composition is formulated as a solid oral dosage form. 12. The method of claim 1, wherein the composition is formulated as a capsule or tablet. 13. The method of claim 1, wherein the composition is formulated for controlled release. 14. The method of claim 1, wherein the composition is formulated as an enteric coated oral dosage form. 15. The method of claim 1, wherein the AM preparation comprises high molecular weight hyaluronan (HA) that is cross-linked by a covalent bond to the heavy chain of inter-α-trypsin inhibitor (IαI), the high molecular weight HA having a molecular weight greater than 1000 kDa. 16. The method of claim 1, wherein the AM preparation comprises tumor necrosis factor-stimulated gene 6 (TSG-6), pentraxin (PTX-3), thrombospondin (TSP-1), and cross-linked high molecular weight hyaluronan (HA). 17. The method of claim 1, wherein the composition is a pharmaceutical composition and further comprises a pharmaceutically-acceptable excipient.
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