Wound treatment dressings comprising combinations of at least one conductive layer, at least one absorbent layer or a moisture regulation layer, and methods of making and methods of use are disclosed for treatment of wounds in humans and animals. The novel dressings aid in healing by helping restore
Wound treatment dressings comprising combinations of at least one conductive layer, at least one absorbent layer or a moisture regulation layer, and methods of making and methods of use are disclosed for treatment of wounds in humans and animals. The novel dressings aid in healing by helping restore the transepithelial potential of the skin, providing a functional anti-microbial barrier, and allowing for regulation of the moisture content of the wound without disturbing the wound.
대표청구항▼
1. A medical device, comprising: at least one non-adherent, permeable, conductive fabric having a surface resistance of about 10 ohms/in2 to about 0.001 ohms/in2, wherein the conductive fabric comprises synthetic polyamide fibers uniformly coated with metallic silver, wherein the coated polyamide fi
1. A medical device, comprising: at least one non-adherent, permeable, conductive fabric having a surface resistance of about 10 ohms/in2 to about 0.001 ohms/in2, wherein the conductive fabric comprises synthetic polyamide fibers uniformly coated with metallic silver, wherein the coated polyamide fibers comprise multiple longitudinal filaments having a uniform three dimensional coating of metallic silver that provide large active surface areas for a given denier per fiber to passively deliver between 3 and 25 micrograms/ml of ionic silver to a wound in about 1 hour to promote or accelerate wound healing;optionally at least one absorbent layer; andoptionally at least one moisture regulation layer comprising a plurality of apertures disposed in the moisture regulation layer, wherein the non-adherent conductive fabric contacts the surface of a wound when the medical device is applied to the wound. 2. The device of claim 1, wherein apertures of the moisture regulation layer allow passage of materials ranging in size from no passage of materials to passage of microbial or environmental contaminants. 3. The device of claim 1, wherein the moisture regulation layer is attached to the at least one absorbent layer or the at least one conductive layer. 4. The device of claim 1, wherein the conductive fabric further comprises at least one non-conductive fiber. 5. The device of claim 4, where in the nonconductive fiber is composed of natural polymers, synthetic polymers, alginates, chitosan, rayon, cotton, polyurethane, or polymeric substrates. 6. The device of claim 1, further comprising an adhesive layer. 7. The device of claim 1, wherein the at least one absorbent layer comprises conductive fibers comprising a three dimensional coating of a metal, and non-conductive fibers, wherein the conductive fibers and nonconductive fibers are uniformly distributed throughout the layer. 8. The device of claim 7, where in the non-conductive fibers are composed of natural polymers, synthetic polymers, alginates, chitosan, rayon, cotton, or polymeric substrates. 9. The device of claim 7, comprising a ratio of conductive fiber to non-conductive fiber is between about 1:100 to 1:0. 10. The device of claim 7, further comprising at least one moisture regulation layer positioned adjacent to the at least one absorbent layer. 11. The device of claim 1, wherein the absorbent layer comprises polymeric sheets, films, or a foam. 12. The device of claim 11, wherein the moisture regulation layer has apertures. 13. The device of claim 11, wherein the moisture regulation layer does not have apertures. 14. The device of claim 1, further comprising multiple conductive or absorbent layers. 15. The device of claim 14, wherein the at least one absorbent layer comprises a plurality of layers, each layer increasing in thickness as the proximity from the wound increases. 16. The device of claim 14, wherein the conductive layers and absorbent layers alternate. 17. The device of claim 1 wherein the apertures comprise a geometric shape having curved lines, straight lines, or a combination thereof. 18. The device of claim 1 wherein the device is selected from the group consisting of a pad, a tampon, a tubular configuration, an island dressing, and a strip dressing. 19. The medical device of claim 1, wherein the synthetic polyimide fibers are uniformly coated with metallic silver by autocatalytic metal plating. 20. A medical device consisting of one non-adherent, permeable, conductive layer having a surface resistance of about 10 ohms/in2 to about 0.001 ohms/in2 comprising a synthetic foam with large active surface areas having a uniform three dimensional coating of metallic silver to passively deliver 3 to 25 micrograms/ml of ionic silver in about 1 hour to a wound to promote or accelerate wound healing. 21. The medical device of claim 20 wherein the foam comprises polyurethane.
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