초록

The present invention relates to a two stage process to control the butanol concentration from fermentation broth.

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1. A method for controlling the concentration of butanol at or below a predetermined level in one or more fermentation broths comprising butanol and water and contained in one or more respective fermentation vessels, said method comprising: (a) continuously removing a portion of at least one of the

1. A method for controlling the concentration of butanol at or below a predetermined level in one or more fermentation broths comprising butanol and water and contained in one or more respective fermentation vessels, said method comprising: (a) continuously removing a portion of at least one of the fermentation broths from its respective fermentation vessel to form a removed fermentation broth;(b) feeding the removed fermentation broth into a stripping section of an apparatus in which said stripping section is in gaseous communication, but not liquid communication, with an associated absorption section, the apparatus having at least one stripping section with an associated absorption section;(c) simultaneously feeding an inert gas into the stripping section, thereby causing a portion of the butanol to leave the fermentation broth and form (i) a gaseous mixture comprising butanol and the inert gas and (ii) a reduced-butanol fermentation broth;(d) returning the reduced-butanol fermentation broth to its respective fermentation vessel, and allowing the gaseous mixture to enter the absorption section of the apparatus that is associated with the stripping section of step (b);(e) continuously feeding into the absorption section of step (d) an organic liquid absorbent having a lower vapor pressure than that of butanol and an ability to absorb butanol, thereby forming a liquid mixture comprising the liquid absorbent and at least a portion of the butanol from the gaseous mixture, thereby reducing the butanol content in the gaseous mixture to form a reduced-butanol gaseous mixture;(f) returning the reduced-butanol gaseous mixture to a stripping section of the apparatus; and(g) recovering butanol from the liquid mixture and returning the liquid absorbent to an absorption section of the apparatus;thereby, as a result of the method, controlling the concentration of butanol in the fermentation broth. 2. The process of claim 1, wherein removal from the same fermentation vessel is simultaneous for two or more fermentation broth streams. 3. The process of claim 1, wherein removal of the two or more fermentation broth streams is non-simultaneous. 4. The process of claim 1, wherein removal from different fermentation vessels is simultaneous for two or more fermentation broth streams. 5. The process of claim 1, wherein removal from different fermentation vessels is non-simultaneous for two or more fermentation broth streams. 6. The process of claim 4 or 5, wherein removal from different fermentation vessels is separate for two or more fermentation broth streams. 7. The process of claim 1 wherein the inert gas is nitrogen. 8. The process of claim 1, wherein the inert gas is CO2. 9. The process of claim 1, wherein the stripping apparatus is located inside the fermentation vessel. 10. The process of claim 1, wherein the stripping apparatus is located exterior to the fermentation vessel. 11. The process of claim 1, wherein the organic liquid absorbent is a C8 or higher alcohol. 12. The process of claim 11, wherein the alcohol is selected from the group consisting of octanol, nonanol, and decanol and mixtures thereof. 13. The process of claim 12, wherein the alcohol is decanol. 14. The process of claim 1, wherein the butanol is recovered by distillation. 15. The process of claim 1, wherein recovery of butanol is selected from the group consisting of absorption, liquid-liquid extraction and crystallization. 16. A method for recycling at least one fermentation broth comprising fermentation microorganisms from a fermentation process wherein butanol is produced in at least one fermentation vessel, said method comprising: (a) removing a portion of the fermentation broth comprising fermentation microorganisms wherein said butanol is produced from its respective fermentation vessel to form a removed fermentation broth comprising fermentation microorganisms;(b) feeding the removed fermentation broth comprising fermentation microorganisms into a stripping section of an apparatus in which said stripping section is in gaseous communication, but not liquid communication, with an associated absorption section, the apparatus having at least one stripping section with an associated absorption section;(c) simultaneously feeding an inert gas into the stripping section, thereby causing a portion of the butanol to leave the removed fermentation broth comprising fermentation microorganisms and form (i) a gaseous mixture comprising butanol and the inert gas and (ii) a reduced-butanol fermentation broth comprising fermentation microorganisms; and(d) returning the reduced-butanol fermentation broth comprising fermentation microorganisms to its respective fermentation vessel. 17. The process of claim 16, wherein the inert gas is nitrogen. 18. The process of claim 16, wherein the inert gas is CO2. 19. An intermediate composition comprising a butanol-rich absorbent phase comprising about 5% to about 15% butanol and an organic liquid absorbent having a lower vapor pressure than butanol. 20. The composition of claim 19, wherein the liquid absorbent is a C8 or higher alcohol. 21. The composition of claim 20, wherein the alcohol is selected from the group consisting of octanol, nonanol, decanol and mixtures thereof. 22. The composition of claim 20 or 21, wherein the alcohol is decanol.