IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0030161
(2008-02-12)
|
등록번호 |
US-8460650
(2013-06-11)
|
발명자
/ 주소 |
- Edinger, James W.
- Hariri, Robert J.
- Wang, Jia-Lun
- Ye, Qian
- Faleck, Herbert
|
출원인 / 주소 |
- Anthrogenesis Corporation
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
7 인용 특허 :
207 |
초록
▼
Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin sy
Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
대표청구항
▼
1. A method of treating an individual having or at risk of developing inflammatory bowel disease, comprising administering to the individual a therapeutically effective amount of non-hematopoietic placental stem cells, wherein said placental stem cells are CD10+, CD34−, CD105+, CD200+, and CD117− as
1. A method of treating an individual having or at risk of developing inflammatory bowel disease, comprising administering to the individual a therapeutically effective amount of non-hematopoietic placental stem cells, wherein said placental stem cells are CD10+, CD34−, CD105+, CD200+, and CD117− as detectable by flow cytometry, wherein the therapeutically effective amount is an amount sufficient to cause a detectable improvement in one or more symptoms of said inflammatory bowel disease, and wherein said administering is by intravenous, subcutaneous, or parenteral administration. 2. A method of treating an individual having inflammatory bowel disease, comprising administering to the individual a therapeutically effective amount of non-hematopoietic placental stem cells, wherein said placental stem cells are CD34−, CD10+, CD117−, and CD105+, as detectable by flow cytometry, and adherent to tissue culture plastic, wherein the therapeutically effective amount is an amount sufficient to cause a detectable improvement in one or more symptoms of said inflammatory bowel disease, and wherein said administering is by intravenous, subcutaneous, or parenteral administration. 3. The method of claim 2, wherein said placental stem cells are additionally one or more of CD45−, CD133−, CD13+, CD44+, CD90+, or HLA-G+, as detectable by flow cytometry. 4. The method of claim 2, wherein said placental stem cells are additionally CD45−, CD133−, CD13+, CD44+, CD90+, and HLA-G+, as detectable by flow cytometry. 5. The method of claim 2, wherein said inflammatory bowel disease is ulcerative colitis. 6. The method of claim 2, wherein said inflammatory bowel disease is Crohn's disease. 7. The method of claim 2, wherein said symptom is one or more of inflammation and swelling of a part of the gastrointestinal tract, abdominal pain, frequent emptying of the bowel, diarrhea, rectal bleeding, anemia, weight loss, arthritis, fever, thickening of the intestinal wall, formation of scar tissue in the intestines, formation of sores or ulcers in the intestine, development of one or more fistulas in the intestinal wall, or development of one or more fissures in the anus. 8. The method of claim 2, comprising administering a second therapeutic agent to said individual. 9. The method of claim 8, wherein said second therapeutic agent is one or more of an anti-inflammatory agent, an immunosuppressant compound, or an antibiotic. 10. The method of claim 1, wherein said administration of placental stem cells comprises intravenous administration. 11. The method of claim 2, wherein said administration of placental stem cells comprises intravenous administration. 12. The method of claim 1, wherein 1×108 to 5×108 placental stem cells are administered. 13. The method of claim 2, wherein 1×108 to 5×108 placental stem cells are administered. 14. The method of claim 1, wherein between 1 million and 10 billion placental stem cells are administered. 15. The method of claim 2, wherein between 1 million and 10 billion placental stem cells are administered. 16. The method of claim 1, wherein said administration of placental stem cells comprises subcutaneous administration. 17. The method of claim 2, wherein said administration of placental stem cells comprises subcutaneous administration. 18. The method of claim 1, wherein said administration of placental stem cells comprises parenteral administration. 19. The method of claim 2, wherein said administration of placental stem cells comprises parenteral administration. 20. The method of claim 1, comprising administering a second therapeutic agent to said individual. 21. The method of claim 20, wherein said second therapeutic agent is one or more of an anti-inflammatory agent, an immunosuppressant compound, or an antibiotic. 22. The method of claim 1, wherein said inflammatory bowel disease is ulcerative colitis. 23. The method of claim 1, wherein said inflammatory bowel disease is Crohn's disease. 24. The method of claim 1, wherein said symptom is one or more of inflammation and swelling of a part of the gastrointestinal tract, abdominal pain, frequent emptying of the bowel, diarrhea, rectal bleeding, anemia, weight loss, arthritis, fever, thickening of the intestinal wall, formation of scar tissue in the intestines, formation of sores or ulcers in the intestine, development of one or more fistulas in the intestinal wall, or development of one or more fissures in the anus. 25. The method of claim 7, wherein said symptom is one or more of diarrhea, abdominal pain, inflammation and swelling of a part of the gastrointestinal tract, formation of scar tissue in the intestines, formation of sores or ulcers in the intestine, development of one or more fistulas in the intestinal wall, or development of one or more fissures in the anus. 26. The method of claim 24, wherein said symptom is one or more of diarrhea, abdominal pain, inflammation and swelling of a part of the gastrointestinal tract, formation of scar tissue in the intestines, formation of sores or ulcers in the intestine, development of one or more fistulas in the intestinal wall, or development of one or more fissures in the anus. 27. The method of claim 1, wherein said placental stem cells are additionally one or more of CD45−, CD133−, CD13+, CD44+, CD90+, or HLA-G+, as detectable by flow cytometry. 28. The method of claim 1, wherein said placental stem cells are additionally CD45−, CD133−, CD13+, CD44+, CD90+, and HLA-G+, as detectable by flow cytometry.
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