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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0658385 (2012-10-23) |
등록번호 | US-8460695 (2013-06-11) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 361 |
Surgical prostheses and methods of using and making surgical prostheses are disclosed.
1. A method of making a surgical prosthesis, the method comprising the steps of: providing a fabric comprising a first layer formed substantially of non-biodegradable yarn and a second layer formed of biodegradable yarn;providing a liquid formulation comprising macromers and an initiator;placing the
1. A method of making a surgical prosthesis, the method comprising the steps of: providing a fabric comprising a first layer formed substantially of non-biodegradable yarn and a second layer formed of biodegradable yarn;providing a liquid formulation comprising macromers and an initiator;placing the fabric within the liquid formulation such that the second layer is in fluid contact with the liquid formulation; andexposing the liquid formulation to a light source. 2. The method of claim 1, wherein the initiator is a photoinitiator. 3. The method of claim 2, wherein the photoinitiator comprises Eosin Y. 4. The method of claim 1, wherein the liquid formulation further comprises biopolymers, an accelerant and a buffer. 5. The method of claim 4, wherein the biopolymers comprise at least one polyanionic polysaccharide modified by reaction with carbodiimide. 6. The method of claim 4, wherein the buffer comprises triethanolamine. 7. The method of claim 4, wherein the buffer comprises potassium phosphate. 8. The method of claim 4, wherein the accelerant comprises N-vinylcaprolactam. 9. The method of claim 1, wherein the liquid formulation comprises 1 weight percent of carbodiimide-modified hyaluronic acid and carboxymethylcellulose, 2.5 weight percent poly(ethylene glycol)-trimethlyene carbonate/lactate multi-block polymers endcapped with acrylate esters, 40 ppm of Eosin Y, 4000 ppm N-vinylcaprolactam, 0.54 weight percent triethanolamine, 0.8 weight percent of potassium phosphate. 10. The method of claim 1, wherein the light source is an LED array having an intensity of about 1 to about 100 mW/cm2. 11. A method of making a surgical prosthesis, the method comprising the steps of: providing a fabric comprising a first layer formed substantially of non-biodegradable yarn and a second layer formed of biodegradable yarn;providing a liquid formulation comprising a first polymer system, a second polymer system, and a photoinitiator;placing the fabric over the liquid formulation such that the second layer is in fluid contact with the liquid formulation; andexposing the liquid formulation to a light source to activate the photoinitiator so as to cause polymerization of at least one of the polymer systems in the liquid formulation. 12. The method of claim 11, wherein the polymerization of at least one of the polymer systems results in the formation of a barrier layer partially embedded within the second layer of the fabric. 13. The method of claim 12, wherein the first polymer system comprises carbodiimide-modified hyaluronic acid and carbodiimide-modified carboxymethylcellulose and the second polymer system comprises poly(ethylene glycol)-trimethylene carbonate/lactate multi-block polymers endcapped with acrylate esters. 14. The method of claim 13, wherein the photoinitiator comprises Eosin Y. 15. The method of claim 14, wherein the liquid formulation further comprises an accelerant and at least one buffer. 16. The method of claim 15, wherein the liquid formulation further comprises a first buffer and a second buffer. 17. The method of claim 16, wherein the accelerant comprises N-vinylcaprolactam, the first buffer comprises triethanolamine, and the second buffer comprises potassium phosphate. 18. The method of claim 11, wherein the light source is an LED array having an intensity of about 1 to about 100 mW/cm2. 19. The method of claim 12, further comprising drying the fabric and the barrier layer in a connection oven.
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