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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0940265 (2004-09-14) |
등록번호 | US-8460710 (2013-06-11) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 267 |
An antibiotic product is comprised of at least three dosage forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours after the initial release of antibiotic. In one embodiment, there are two delayed release dosage fo
An antibiotic product is comprised of at least three dosage forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours after the initial release of antibiotic. In one embodiment, there are two delayed release dosage forms, as well as a delayed sustained release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
1. A once-a-day antibiotic product comprising: first, second, and third dosage forms, each of said antibiotic dosage forms comprising at least one antibiotic and a pharmaceutically acceptable carrier, said first and second antibiotic dosage forms being a delayed release dosage forms, said third anti
1. A once-a-day antibiotic product comprising: first, second, and third dosage forms, each of said antibiotic dosage forms comprising at least one antibiotic and a pharmaceutically acceptable carrier, said first and second antibiotic dosage forms being a delayed release dosage forms, said third antibiotic dosage form being a delayed sustained release dosage form, wherein said third dosage form initiates release of antibiotic at about the same time as said second dosage form initiates release of antibiotic or wherein said third dosage form initiates release of antibiotic after said second dosage form initiates release of antibiotic, and wherein said second dosage form initiates release of antibiotic after said first dosage form initiates release of antibiotic, Cmax of the total antibiotic release from said antibiotic product is achieved in less than 12 hours from initial release of antibiotic, said once-a-day antibiotic product contains the total dosage of the at least one antibiotic for a twenty-four hour period, wherein said at least one antibiotic has a half life of 2-10 hours, and said once-a-day product is an oral dosage form and is free of immediate release dosage forms. 2. The product of claim 1, wherein said third dosage form initiates release of antibiotic at about the same time as said second dosage form initiates release of antibiotic. 3. The product of claim 1, wherein said third dosage form initiates release of antibiotic after said second dosage form initiates release of antibiotic. 4. The product of claim 1, wherein the Cmax for the product is reached no earlier than four hours after initial release of antibiotic. 5. The product of claim 1, wherein the antibiotic release from the first dosage form reaches a Cmax within from about 0.5 hours to about 2 hours after initial release of antibiotic. 6. The product of claim 1, wherein the antibiotic released from the second dosage form reaches a Cmax after Cmax is reached for the antibiotic released from the first dosage form. 7. The product of claim 1, wherein the antibiotic released from the third dosage form reaches a Cmax after Cmax is reached for the antibiotic released from the second dosage form. 8. The product of claim 1, wherein the first dosage form contains about 20-70% of the total dosage of antibiotic, the second dosage form contains about 10-70% of the total dosage of antibiotic, and the third dosage contains about 10-70% of the total dosage of antibiotic. 9. The product of claim 1, wherein the first dosage form contains about 25-66% of the total dosage of antibiotic, the second dosage form contains about 15-60% of the total dosage of antibiotic, and the third dosage form contains about 15-60% of the total dosage of antibiotic. 10. The product of claim 1, wherein the first dosage form contains about 33-60% of the total dosage of antibiotic, the second dosage form contains about 25-50% of the total dosage of antibiotic, and the third dosage form contains about 25-50% of the total dosage of antibiotic. 11. The product of claim 1 further comprising a fourth antibiotic dosage form, said fourth antibiotic dosage form being either a sustained or a delayed release dosage form and comprising at least one antibiotic and a pharmaceutically acceptable carrier and wherein said at least one antibiotic released from said fourth antibiotic dosage form reaches a Cmax after Cmax is achieved for antibiotic release from each of said first, second, and third dosage forms. 12. The product of claim 11, wherein the Cmax for the product is reached no earlier than four hours after initial release of antibiotic. 13. The product of claim 11, wherein the antibiotic released from the first dosage form reaches a Cmax within from about 0.5 hours to about 2 hours after initial release of antibiotic. 14. The product of claim 11, wherein the antibiotic released from the second dosage form reaches a Cmax in no more than 4 hours after initial release of antibiotic. 15. The product of claim 11, wherein the product is an oral dosage form. 16. The product of claim 11, wherein the antibiotic released from the second dosage form reaches a Cmax after Cmax is reached for the antibiotic released from the first dosage form. 17. The product of claim 11, wherein the antibiotic released from the third dosage form reaches a Cmax after Cmax is reached for the antibiotic released from the second dosage forms. 18. A process for treating a bacterial infection in a host comprising: administering to a host of antibiotic product of claim 1, once-a-day, 19. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 2, once-a-day. 20. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product f claim 3, once-a-day. 21. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 4, once-a-day. 22. A process for treating a bacterial infection in a lost comprising: administering to a host the antibiotic product of claim 5, once-a-day. 23. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 6, once-a-day. 24. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 7, once-a-day. 25. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 8, once-a-day, 26. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 9, once-a-day. 27. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 10, once-a-day 28. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 11, once-a-day. 29. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 12, once-a-day. 30. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 13, once-a-day. 31. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 14, once-a-day. 32. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 15, once-a-day. 33. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 16, at ,a-day. 34. A process for treating a bacterial infection in a host comprising: administering to a host the antibiotic product of claim 17, once-a-day, 35. A once-a-day antibiotic product comprising: first, second, and third dosage forms, each of said antibiotic dosage forms comprising amoxicillin and pharmaceutically acceptable carrier, said first and second antibiotic dosage forms being a delayed release dosage forms, said third antibiotic dosage form being delayed sustained release dosage form, wherein said third dosage form initiates release of amoxicillin at about the same time as said second dosage form initiates release of amoxicillin or wherein said third dosage form initiates release of amoxicillin after said second dosage form initiates release of amoxicillin, and wherein said second dosage form initiates release of amoxicillin after said first dosage form initiates release of amoxicillin, Cmax of the total amoxicillin released from said antibiotic product is achieved in less than 12 hours from initial release of amoxicillin, said once-a-day antibiotic product contains the total dosage of amoxicillin for a twenty-four hour period, and said once-a-day product is an oral dosage form and is free of immediate release dosage forms. 36. A once-a-day antibiotic product comprising: first, second, and third dosage forms, each of said antibiotic dosage forms comprising azithromycin and a pharmaceutically acceptable carrier, said first and second antibiotic dosage forms being a delayed release dosage forms, said third antibiotic dosage form being a delayed sustained release dosage form, wherein said third dosage form initiates release of azithromycin at about the same ti e as said second dosage form initiates release of azithromycin car wherein said third dosage form initiates release of azithromycin after said second dosage form initiates release of azithromycin, and wherein said second dosage form initiates release of azithromycin after said first dosage form initiates release of a azithromycin, Cmax of the total azithromycin released from said antibiotic product is achieved in less than 12hours from initial release of azithromycin, said once-a-day antibiotic product contains the total dosage or azithromycin for a twenty-four hour period, and said once-a-day product is an oral dosage form and is free of immediate release dosage forms. 37. The product of claim 1, wherein the at least one antibiotic with a half life of 2-10 hours is ciprofloxacin, ceftibuten, or levofloxacin.
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