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Methods and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug are disclosed. The methods and apparatus provide for automatic

Methods and apparatus for sealing a puncture or incision formed percutaneously in tissue separating two internal portions of the body of a living being with an anchor, a sealing plug and a filament connecting the anchor and sealing plug are disclosed. The methods and apparatus provide for automatic tamping of the sealing plug. In addition, torque required to tamp the sealing plug is automatically sensed and gear ratios of an automatic tamping device are automatically changed in response to sensed changes in torque. A planetary transmission may be used to automatically change gear ratios in response to the changes in torque.

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1. A method of sealing a tissue puncture, comprising: providing a tissue puncture closure device comprising a filament, an anchor, a sealing plug slidingly attached to the filament adjacent to the anchor, a tamping tube, and an automatic transmission, the automatic transmission comprising a filament

1. A method of sealing a tissue puncture, comprising: providing a tissue puncture closure device comprising a filament, an anchor, a sealing plug slidingly attached to the filament adjacent to the anchor, a tamping tube, and an automatic transmission, the automatic transmission comprising a filament spool, an input gear, an output gear, at least two intermediate gears, and a clutch member operable between the at least two intermediate gears;deploying the anchor in the tissue puncture;at least partially withdrawing the closure device;automatically changing a gear ratio between the input and output gears to achieve a mechanical advantage when a torque of the automatic transmission exceeds a clutch breakdown value to increase a force applied to the sealing plug by the tamping tube, and automatically decrease a mechanical advantage when the torque falls below the clutch breakdown value. 2. The method of claim 1, wherein the filament is wrapped around the filament spool, the filament spool and input gear are arranged coaxially, and unwinding the filament from the filament spool upon at least partially withdrawing the closure device rotates the filament spool and input gear. 3. The method of claim 1, wherein the at least two intermediate gears are operable between the input and output gears to provide the mechanical advantage. 4. The method of claim 1, wherein the at least two intermediate gears are part of a planetary gearset that provides the mechanical advantage. 5. The method of claim 1, wherein the output gear is in contact with the tamping tube, and rotating the output gear advances the tamping tube to compact the sealing plug. 6. The method of claim 1, further comprising inserting the closure device through a percutaneous incision to position the anchor in the tissue puncture. 7. A method of sealing a tissue puncture, comprising: providing a tissue puncture closure device comprising a filament, an anchor, a sealing plug, a tamping tube, and an automatic transmission, the automatic transmission comprising a filament spool, an input gear arranged coaxially with the filament spool, an output gear in contact with the tamping tube, and a clutch member having a predetermined torque breakdown value releasably engaging at least two of the gears;advancing the closure device into the tissue puncture;deploying the anchor in the tissue puncture;at least partially withdrawing the closure device;automatically changing a gear ratio between the input and output gears to achieve a mechanical advantage when a torque of the automatic transmission exceeds the clutch breakdown value to increase a force applied to the sealing plug, and automatically decrease a mechanical advantage when the torque falls below the clutch breakdown value. 8. The method of claim 7, wherein the automatic transmission includes a plurality of intermediate gears operable between the input and output gears to provide the mechanical advantage. 9. The method of claim 8, wherein the plurality of intermediate gears are part of a planetary gearset operable to automatically change the gear ratio. 10. The method of claim 7, wherein at least partially withdrawing the closure device unwinds a portion of the filament from the filament spool. 11. The method of claim 7, wherein the clutch member is operable between the input gear and the filament spool. 12. A method of sealing a tissue puncture, comprising: providing a tissue puncture closure device comprising a filament, an anchor, a sealing plug, a tamping tube, and an automatic transmission, the automatic transmission comprising a filament spool, an input gear, an output gear, and at least one intermediate gear;advancing the closure device into the tissue puncture;deploying the anchor in the tissue puncture;at least partially withdrawing the closure device;automatically changing a gear ratio between the input and output gears to achieve an additional mechanical advantage when a torque of the automatic transmission exceeds a clutch breakdown value and to achieve a decreased mechanical advantage when the torque falls below the clutch breakdown value. 13. The method of claim 12, wherein the spool and gears of the automatic transmission each have a rotation axis that is arranged perpendicular to a direction of withdrawing the closure device. 14. The method of claim 12, wherein the at least one intermediate gear includes a plurality of intermediate gears, and automatically changing the gear ratio includes operating different gears of the plurality of intermediate gears. 15. The method of claim 12, wherein at least partially withdrawing the closure device rotates the filament spool, which rotates the input gear and the at least one intermediate gear. 16. The method of claim 12, wherein the filament spool and input gear are arranged coaxially, and the output gear and input gear are positioned radially spaced apart from each other. 17. A method of sealing a tissue puncture, comprising: providing a tissue puncture closure device comprising an anchor, a sealing plug, a filament coupled to the anchor and sealing plug, and an automatic transmission, the automatic transmission comprising a filament spool having a portion of the filament wound thereon, an input gear, an output gear, and at least one intermediate gear;advancing the closure device into the tissue puncture;deploying the anchor in the tissue puncture;at least partially withdrawing the closure device;automatically compacting the sealing plug;automatically changing a gear ratio between the input and output gears during compacting the sealing plug to achieve an additional mechanical advantage when a torque of the automatic transmission exceeds a clutch breakdown value and to achieve a decreased mechanical advantage when the torque falls below the clutch breakdown value. 18. The method of claim 17, wherein automatically compacting the sealing plug includes advancing the tamping tube with the automatic transmission. 19. The method of claim 17, wherein automatically changing the gear ratio includes changing a gear ratio of the at least one intermediate gear. 20. The method of claim 17, wherein the at least one intermediate gear includes a planetary gearset having a plurality of gears.