Osteogenic implants with combined implant materials and methods for same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61F-002/02
A61F-002/28
A61K-038/00
A61K-038/16
A61K-038/17
A61K-038/18
C07K-014/78
C07K-014/51
출원번호
US-0684480
(2010-01-08)
등록번호
US-8470354
(2013-06-25)
발명자
/ 주소
McKay, William F.
Boden, Scott D.
Beals, Neil B.
출원인 / 주소
Warsaw Orthopedic, Inc.
대리인 / 주소
Sorell Lenna & Schmidt LLP
인용정보
피인용 횟수 :
5인용 특허 :
22
초록▼
Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting b
Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
대표청구항▼
1. A medical implant device, comprising: an implant structure including a first resorbable implant component combined with a second resorbable implant component, the first resorbable implant component comprising a scaffold material comprising ceramic particles, which comprise tricalcium phosphate an
1. A medical implant device, comprising: an implant structure including a first resorbable implant component combined with a second resorbable implant component, the first resorbable implant component comprising a scaffold material comprising ceramic particles, which comprise tricalcium phosphate and hydroxyapatite in a weight ratio of tricalcium phosphate to hydroxyapatite of about 50:50 to about 95:5, the first resorbable implant component comprising a particulate mineral to resorbable porous matrix weight ratio of at least about 10:1, where the ceramic particles resorb more slowly than the second resorbable implant component when the implant structure is implanted in a patient thereby remaining at the implant site for a sufficient period for tissue ingrowth, wherein the second resorbable implant component comprises a polymer sponge carrier, an osteogenic protein and substantially no ceramic particles. 2. The medical implant device of claim 1, wherein the first resorbable implant component comprises a polymer. 3. The medical implant device of claim 1 wherein the first component provides a scaffold that remains in the patient for longer than 12 weeks. 4. The medical implant device of claim 1, wherein the second resorbable implant component is wrapped around the first resorbable implant component. 5. The medical implant device of claim 1, wherein the weight ratio of tricalcium phosphate to hydroxyapatite is about 95:5. 6. A medical implant device, comprising: an implant structure including first resorbable implant component combined with a second resorbable implant component, the first resorbable implant component comprising a scaffold material comprising mineral particles, which comprise tricalcium phosphate and hydroxyapatite in a weight ratio of tricalcium phosphate to hydroxyapatite of about 50:50 to about 95:5, the first resorbable implant component comprising a particulate mineral to resorbable porous matrix weight ratio of at least about 10:1, where the ceramic particles resorb more slowly than the second implant component when the implant structure is implanted in a patient thereby remaining at the implant site for a sufficient period for tissue ingrowth and the second resorbable implant component comprises a polymer sponge carrier, an osteogenic protein, and substantially no mineral particles. 7. The medical implant device of claim 6, wherein the first resorbable implant component comprises a polymer. 8. The medical implant device of claim 6 wherein the first component provides a scaffold that remains in the patient for longer than 12 weeks. 9. The medical implant device of claim 6, wherein the second resorbable implant component is wrapped around the first resorbable implant component. 10. The medical implant device of claim 6, wherein the weight ratio of tricalcium phosphate to hydroxyapatite is about 95:5. 11. A medical implant device, comprising: an implant structure including a first resorbable implant component combined with a second resorbable implant component, the first resorbable implant component comprising a scaffold material comprising ceramic particles, which comprise a weight ratio of tricalcium phosphate to hydroxyapatite of 50:50 to about 95:5, the first resorbable implant component comprising a particulate mineral to resorbable porous matrix weight ratio of at least about 10:1, wherein the ceramic particles resorb more slowly than the second resorbable implant component so that, after implantation of the device in a patient, the second resorbable implant component is resorbed in vivo and the second resorbable implant component comprises a polymer sponge carrier, bone morphogenic protein, and no ceramic particles. 12. The medical implant device of claim 11, wherein the second resorbable implant component is wrapped around the first resorbable implant component. 13. The medical implant device of claim 11, wherein the weight ratio of tricalcium phosphate to hydroxyapatite is about 95:5. 14. A device for tissue repair or replacement, comprising first and second components having differing relative rates of in vivo degradation, the second component comprising a polymer sponge carrier, an osteogenic protein and no ceramic particles and having a higher rate of in vivo degradation than the first component, the first and second components being arranged relative to each other so that, after implantation of the device, the second component degrades in vivo and the first component comprises ceramic particles, which comprise tricalcium phosphate and hydroxyapatite in a weight ratio of tricalcium phosphate to hydroxyapatite of about 50:50 to about 95:5 and comprising a particulate mineral to resorbable porous matrix weight ratio of at least about 10:1. 15. The device of claim 14, wherein the second resorbable implant component is wrapped around the first resorbable implant component. 16. The device of claim 14, wherein the weight ratio of tricalcium phosphate to hydroxyapatite is about 95:5.
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이 특허에 인용된 특허 (22)
Silverberg Mark (2901 S. King Dr. ; Apt. #909 Chicago IL 60616), Bone augmentation implant.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Brea CA), Calcium phosphate/atelopeptide collagen compositions for bone repair.
Smestad Thomas L. (Palo Alto CA) Prows Daniel (Los Gatos CA) Chu George H. (Cupertino CA) Hendericks Diana M. (Brea CA) Brown Debera (Palo Alto CA), Gamma irradiation of collagen/mineral mixtures.
Smestad Thomas L. (Palo Alto CA) Prows Daniel (Santa Clara CA) Chu George H. (Sunnyvale CA) Hendricks Diana M. (Brea CA), Gamma irradiation of collagen/mineral mixtures.
Lemons J. E. (c/o University of Alabama in Birmingham ; School of Dentistry ; Box 49 Birmingham AL 35294), Inorganic and organic composition for treatment of bone lesions.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Method of making molds with xenogeneic collagen/mineral preparations for bone repair.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Brea CA), Xenogeneic collagen/mineral preparations in bone repair.
Boyd, Lawrence M.; Ratcliffe, Jr., John J.; Adamson, Tim E.; Grata, Paul J., Instrument and system for placing graft, implant and graft material for minimally invasive posterolateral fusion.
Boyd, Lawrence M.; Ratcliffe, Jr., John J.; Morin, Joshua; Marigowda, Shresta; Adamson, Tim E.; Robbins, Daniel; Barbieri, Thomas J., Minimally invasive posterolateral fusion.
Vanderploeg, Eric; Seeherman, Howard; Wilson, Christopher G.; Wozney, John; Brown, Christopher T.; Kambouris, John A., Systems and methods for improved delivery of osteoinductive molecules in bone repair.
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