IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0876980
(2010-09-07)
|
등록번호 |
US-8470362
(2013-06-25)
|
발명자
/ 주소 |
- Sawhney, Amarpreet S.
- Khosravi, Farhad
- Pai, Suresh S.
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
4 인용 특허 :
128 |
초록
▼
Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the por
Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
대표청구항
▼
1. A method for sealing a puncture extending through tissue to a body lumen, comprising delivering a plug into the puncture, the plug including first and second precursors disposed thereon in an unreactive state before delivery into the puncture, the plug being exposed to an aqueous physiological en
1. A method for sealing a puncture extending through tissue to a body lumen, comprising delivering a plug into the puncture, the plug including first and second precursors disposed thereon in an unreactive state before delivery into the puncture, the plug being exposed to an aqueous physiological environment within the puncture, whereupon the first and second precursors react within one another to form an adhesive portion on the plug to enhance hemostasis within the puncture. 2. The method of claim 1, wherein the first and second precursors react to form a hydrogel. 3. The method of claim 1, wherein the first and second precursors react to form a tacky coating to adhere the plug to tissue surrounding the puncture. 4. The method of claim 1, wherein the plug comprises a core that is at least partially coated by at least one of the first and second precursors, and wherein the core is exposed to fluid within the puncture as the first and second precursors react with one another. 5. The method of claim 4, wherein the core comprises lyophilized hydrogel that expands substantially when exposed to fluid within the puncture. 6. The method of claim 1, further comprising: introducing a positioning member into the puncture until a positioning element thereon is disposed within the body lumen;partially retracting the positioning member until the positioning element contacts a wall of the body lumen; anddelivering the plug into the puncture over the positioning member until the plug is disposed proximate the positioning element. 7. The method of claim 6, wherein the positioning element comprises an expandable member that is introduced into the puncture in a contracted condition, the method further comprising expanding the expandable member within the body lumen before partially retracting the positioning member. 8. The method of claim 6, wherein the positioning element substantially seals the puncture from the body lumen when the positioning element contacts the wall of the body lumen, and wherein the plug is exposed to the aqueous physiological environment when the expandable member is collapsed, thereby exposing the puncture to fluid within the body lumen. 9. The method of claim 6, further comprising withdrawing the positioning member from the puncture once the plug is exposed to the aqueous physiological environment within the puncture. 10. The method of claim 1, wherein the plug is carried within a tubular member, and wherein the plug is delivered into the puncture by advancing the tubular member into the puncture. 11. The method of claim 10, wherein the plug is exposed to the aqueous environment by retracting the tubular member at least partially from the puncture while maintaining the plug within the puncture. 12. The method of claim 11, wherein the tubular member comprises a tamping member therein, the tubular member being movable relative to the tamping member for deploying the plug from the tubular member. 13. The method of claim 12, further comprising advancing the tamping member within the puncture to compress the plug within the puncture. 14. The method of claim 13, further comprising deploying an occlusion element within a body lumen communicating with the puncture to substantially seal the body lumen from the puncture, and wherein the plug is compressed between the pusher member and the occlusion element. 15. A method for sealing a puncture extending through tissue to a body lumen, comprising delivering a plug into the puncture, the plug including first and second precursors disposed thereon in an unreactive state before delivery into the puncture, the plug being exposed to an aqueous physiological environment within the puncture, whereupon the first and second precursors react within one another to form an adherent layer on the plug to enhance hemostasis within the puncture. 16. A method for sealing a puncture extending through tissue to a body lumen, comprising: providing a sealant including a bioabsorbable carrier and an adherent layer on a portion of the carrier, the adherent layer including first and second precursors in an unreactive state before delivery into the puncture; anddelivering the sealant into the puncture such that the adherent layer is exposed to an aqueous physiological environment within the puncture, whereupon the first and second precursors react within one another to secure the carrier within the puncture. 17. The method of claim 16, wherein the adherent layer further comprises a pH adjusting agent. 18. The method of claim 16, wherein the adherent layer is provided on the carrier by melting the precursors, applying the melted precursors to a surface of the carrier, and cooling the precursors such that they solidify on the surface. 19. The method of claim 16, wherein the first and second precursors react in situ to form a tacky material to adhere the sealant to tissue adjacent the puncture. 20. The method of claim 16, wherein the carrier comprises lyophilized hydrogel that expands substantially when exposed to fluid within the puncture. 21. The method of claim 16, further comprising: introducing a positioning member into the puncture until a positioning element thereon is disposed within the body lumen;partially retracting the positioning member until the positioning element contacts a wall of the body lumen; anddelivering the sealant into the puncture over the positioning member until the sealant is disposed proximate the positioning element. 22. The method of claim 20, further comprising withdrawing the positioning member from the puncture once the plug is exposed to the aqueous physiological environment within the puncture. 23. The method of claim 16, wherein delivering the sealant comprises: introducing a distal end of a tubular member into the puncture; anddeploying the sealant from the distal end of the tubular member. 24. The method of claim 23, wherein the tubular member comprises a tamping member therein, the tubular member being movable relative to the tamping member for deploying the sealant from the tubular member. 25. The method of claim 24, further comprising advancing the tamping member within the puncture to compress the sealant within the puncture. 26. The method of claim 16, wherein the body lumen comprises a blood vessel, and wherein the puncture comprises an arteriotomy in the blood vessel that communicates with a track through tissue, and wherein the sealant is delivered adjacent the arteriotomy. 27. A method for sealing a puncture extending through tissue to a body lumen, comprising: providing a sealant including a bioabsorbable carrier and first and second hydrogel precursors on a portion of the carrier in an unreactive solid state before delivery into the puncture; anddelivering the sealant into the puncture until the sealant is adjacent the body lumen such that the first and second precursors dissolve and react within one another to form an adherent portion that substantially secures the carrier within the puncture relative to the body lumen.
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