초록 ▼

The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene (“UHMWPE”) blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPE material and vitamin E

The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene (“UHMWPE”) blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPE material and vitamin E prior to irradiating the UHMWPE blend with electron beam radiation at a sufficient radiation dose rate to induce crosslinking. The crosslinked UHMWPE blend may be incorporated into a variety of implants, and in particular, into endoprosthetic joint replacements.

대표청구항 ▼

1. A method of forming a crosslinked ultrahigh molecular weight polyethylene blend, comprising: combining ultrahigh molecular weight polyethylene with an amount of vitamin E to form an ultrahigh molecular weight polyethylene blend;consolidating the ultrahigh molecular weight polyethylene blend;prehe

1. A method of forming a crosslinked ultrahigh molecular weight polyethylene blend, comprising: combining ultrahigh molecular weight polyethylene with an amount of vitamin E to form an ultrahigh molecular weight polyethylene blend;consolidating the ultrahigh molecular weight polyethylene blend;preheating the consolidated ultrahigh molecular weight polyethylene blend; andirradiating the preheated consolidated ultrahigh molecular weight polyethylene blend using electron beam irradiation at an absorbed dose of at least about 60 kiloGrey and a dose rate of at least about 18 MegaGrey per hour to crosslink the consolidated ultrahigh molecular weight polyethylene blend. 2. The method of claim 1 wherein the vitamin E is dispersed substantially uniformly throughout the blend. 3. The method of claim 1 wherein the amount of vitamin E combined with the blend is between about 0.02 w/w % and about 2.0 w/w %. 4. The method of claim 1 wherein the amount of vitamin E combined with the blend is between about 0.05 w/w % and about 0.4 w/w %. 5. The method of claim 1 wherein the blend further comprises at least one additional polymer material. 6. The method of claim 1 wherein the consolidated ultrahigh molecular weight polyethylene blend is preheated above room temperature. 7. The method of claim 1 wherein the consolidated ultrahigh molecular weight polyethylene blend is preheated above 100° C. 8. The method of claim 1 wherein the consolidated ultrahigh molecular weight polyethylene blend is preheated to between about 120° C. and about 130° C. 9. The method of claim 1 further including annealing the irradiated consolidated ultrahigh molecular weight polyethylene blend at a temperature up to 200° C. 10. The method of claim 1 further including annealing the irradiated consolidated ultrahigh molecular weight polyethylene blend at a temperature up to 150° C. 11. The method of claim 1 further including annealing the irradiated consolidated ultrahigh molecular weight polyethylene blend at a temperature up to 50° C. 12. The method of claim 1 wherein the consolidated ultrahigh molecular weight polyethylene blend is irradiated with electron beam radiation at an absorbed dose of at least about 95 kiloGrey to form the crosslinked ultrahigh molecular weight polyethylene blend. 13. An implantable article, comprising: a crosslinked ultrahigh molecular weight polyethylene blend, wherein the blend is produced by: combining ultrahigh molecular weight polyethylene with vitamin E to form an ultrahigh molecular weight polyethylene blend;consolidating the ultrahigh molecular weight polyethylene blend;preheating the consolidated ultrahigh molecular weight polyethylene blend;irradiating the preheated consolidated ultrahigh molecular weight polyethylene blend using electron beam irradiation at an absorbed dose of at least about 60 kiloGrey and a dose rate of at least about 18 MegaGrey per hour to crosslink the consolidated ultrahigh molecular weight polyethylene blend; and,annealing the crosslinked consolidated ultrahigh molecular weight polyethylene blend. 14. The implantable article of claim 13 wherein the vitamin E is dispersed substantially uniformly throughout the blend. 15. The implantable article of claim 13 wherein the amount of vitamin E combined with the blend is between about 0.02 w/w % and about 2.0 w/w %. 16. The implantable article of claim 13 wherein the amount of vitamin E combined with the blend is between about 0.05 w/w % and about 0.4 w/w %. 17. The implantable article of claim 13 wherein the blend further comprises at least one additional polymer material. 18. The implantable article of claim 13 wherein the consolidated ultrahigh molecular weight polyethylene blend is preheated above room temperature. 19. The implantable article of claim 13 wherein the consolidated ultrahigh molecular weight polyethylene blend is preheated above 100° C. 20. The implantable article of claim 13 wherein the consolidated ultrahigh molecular weight polyethylene blend is preheated to between about 120° C. and about 130° C. 21. The implantable article of claim 13 further including annealing the irradiated consolidated ultrahigh molecular weight polyethylene blend at a temperature up to 200° C. 22. The implantable article of claim 13 further including annealing the irradiated consolidated ultrahigh molecular weight polyethylene blend at a temperature up to 150° C. 23. The implantable article of claim 13 further including annealing the irradiated consolidated ultrahigh molecular weight polyethylene blend at a temperature up to 50° C. 24. The implantable article of claim 13 wherein the consolidated ultrahigh molecular weight polyethylene blend is irradiated with electron beam radiation at an absorbed dose of at least about 95 kiloGrey to form the crosslinked ultrahigh molecular weight polyethylene blend.