IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0424946
(2009-04-16)
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| 등록번호 |
US-8475844
(2013-07-02)
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|
발명자
/ 주소 |
- Kocur, Gordon
- Rolf, David
- Lasch, James
- Seethamraju, Kasyap
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| 출원인 / 주소 |
- Boston Scientific Scimed, Inc.
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| 대리인 / 주소 |
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| 인용정보 |
피인용 횟수 :
0 인용 특허 :
30 |
초록
▼
Polymers of fluorinated monomers and acrylate and alkyl acrylates are disclosed which demonstrate improved performance as coatings for implantable devices. Such coatings may, for example, be used to release a bioactive agent from the medical device. One specific application lies in drug-eluting coat
Polymers of fluorinated monomers and acrylate and alkyl acrylates are disclosed which demonstrate improved performance as coatings for implantable devices. Such coatings may, for example, be used to release a bioactive agent from the medical device. One specific application lies in drug-eluting coatings for stents.
대표청구항
▼
1. A medical implant comprising a coating that comprises a copolymer composition, said copolymer composition comprising: a fluoromonomer unit selected from the group consisting of vinylidene difluoride, hexafluoropropylene and combinations thereof; andan acrylate monomer unit of the formula I, where
1. A medical implant comprising a coating that comprises a copolymer composition, said copolymer composition comprising: a fluoromonomer unit selected from the group consisting of vinylidene difluoride, hexafluoropropylene and combinations thereof; andan acrylate monomer unit of the formula I, wherein R1 is a C1-C10 alkyl and R2 is H or CH3. 2. The medical implant of claim 1, wherein the mole % of said acrylate monomer unit in the copolymer composition is 50% or lower. 3. The medical implant of claim 1, wherein the mole % of said acrylate monomer unit in the copolymer composition is selected from the group consisting of 10-20%, 10-50%, and 25-50%. 4. The medical implant of claim 1, wherein the copolymer composition has a glass transition temperature of less than 35° C. 5. The medical implant of claim 1, wherein the copolymer composition has a glass transition temperature of less than 20° C. 6. The medical implant of claim 1, wherein the copolymer composition comprises a random copolymer, a block copolymer, or a graft copolymer. 7. The medical implant of claim 1, wherein the acrylate monomer unit is selected from the group consisting of methylmethacrylate, ethylmethacrylate, butylmethacrylate, hexylmethacrylate, methacrylate, n-butylacrylate, ethylacrylate, and any combination thereof. 8. The medical implant of claim 1, further comprising a bioactive agent. 9. The medical implant of claim 8, wherein said bioactive agent is an antithrombotic agent. 10. The medical implant of claim 1, further comprising an additional monomer unit wherein said additional monomer unit is present at less than 10 mole % of the composition. 11. A medical implant comprising a coating that comprises a copolymer composition, said copolymer composition comprising: a fluoromonomer unit selected from the group consisting of vinylidene difluoride, hexafluoropropylene and combinations thereof; and,an acrylate monomer unit of formula V, 12. The medical implant of claim 11, wherein the mole % of said acrylate monomer unit in the copolymer composition is 50% or lower. 13. The medical implant of claim 11, wherein the mole % of said acrylate monomer unit in the copolymer composition is selected from the group consisting of 10-20%, 10-50%, and 25-50%. 14. The medical implant of claim 11, having a glass transition temperature of less than 35° C. 15. The medical implant of claim 14, having a glass transition temperature of less than 20° C. 16. The medical implant of claim 11, wherein the copolymer composition comprises a random copolymer, a block copolymer, or a graft copolymer. 17. The medical implant of claim 11, further comprising a bioactive agent. 18. The medical implant of claim 17, wherein said bioactive agent is an antithrombotic agent. 19. The medical implant of claim 11, further comprising an additional monomer unit wherein said additional monomer unit is present at less than 10 mole % of the composition. 20. A medical implant comprising a coating that comprises a polymer blend composition, said copolymer composition comprising: a fluoromonomer unit selected from the group consisting of vinylidene difluoride, hexafluoropropylene and combinations thereof; anda polyacrylate having a monomer unit of the formula I, wherein R1 is a C1-C10 alkyl and R2 is H or CH3. 21. The medical implant of claim 20, wherein said polymer blend further comprises a third polymer, said third polymer being substantially free of fluoromonomers and acrylate monomers. 22. The medical implant of claim 1, wherein R1 is other than methyl. 23. The medical implant of claim 22, wherein said copolymer composition comprises a block copolymer or a graft copolymer. 24. The medical implant of claim 1, wherein said copolymer composition comprises a block copolymer or a graft copolymer. 25. The medical implant of claim 22, wherein the an acrylate monomer unit is of formula V, and wherein m =1-6. 26. The medical implant of claim 1, wherein said copolymer composition does not comprise an additional acrylate monomer unit having a polar functional group selected from a carboxylate group, an amine group, an alcohol group, and amide group, a nitro group and a cyano group. 27. The medical implant of claim 1, wherein said copolymer composition comprises more than one type of acrylate monomer unit. 28. The medical implant of claim 1, selected from stents, stent-grafts, grafts, artificial heart valves, cerebrospinal fluid shunts, pacemaker electrodes, and endocardial leads. 29. The medical implant of claim 22, wherein said copolymer composition does not comprise an additional acrylate monomer unit having a polar functional group selected from a carboxylate group, an amine group, an alcohol group, and amide group, a nitro group and a cyano group. 30. The medical implant of claim 22, wherein said copolymer composition comprises more than one type of acrylate monomer unit. 31. The medical implant of claim 22, selected from stents, stent-grafts, grafts, artificial heart valves, cerebrospinal fluid shunts, pacemaker electrodes, and endocardial leads.
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