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Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

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1. A method for performing a diagnostic of an analyte sensor system, comprising: providing a sensor system comprising an analyte sensor and a flow control device configured to intermittently expose the analyte sensor to a biological sample and an infusion solution, wherein the analyte sensor compris

1. A method for performing a diagnostic of an analyte sensor system, comprising: providing a sensor system comprising an analyte sensor and a flow control device configured to intermittently expose the analyte sensor to a biological sample and an infusion solution, wherein the analyte sensor comprises: a first working electrode configured to provide a first signal comprising an analyte component and a baseline component; anda second working electrode configured to provide a second signal comprising a baseline component substantially without an analyte component, wherein the second signal comprises a signal waveform; andevaluating the sensor system, using a processor module, based at least in part on the second signal, wherein evaluating the sensor system comprises evaluating the signal waveform for at least one of an expected shape or a pattern when the analyte sensor is exposed to at least one of the biological sample or the infusion solution, wherein at least one of the expected shape or pattern corresponds to a change in analyte concentration between the analyte concentration of the biological sample and the analyte concentration of the infusion solution. 2. The method of claim 1, wherein evaluating the signal waveform comprises evaluating at least one of a similarity or a correlation between the signal waveform and a waveform template. 3. The method of claim 2, wherein the waveform template is based at least in part on a priori information. 4. The method of claim 2, wherein evaluating at least one of a similarity or a correlation of the signal waveform to a waveform template comprises performing a correlation waveform analysis. 5. The method of claim 2, further comprising updating the waveform template when at least one of the similarity or the correlation between the signal waveform and the waveform template meets one or more criteria. 6. The method of claim 5, further comprising detecting a level of interferent in the biological sample, wherein the waveform template is updated when the level of interferent meets one or more criteria. 7. The method of claim 1, wherein evaluating the sensor system comprises detecting an interferent by evaluating at least one of an amplitude, a change in amplitude, a signal waveform, or a change in a signal waveform of the second signal when the sensor is exposed to the biological sample. 8. The method of claim 7, wherein detecting an interferent is further based at least in part on a calibrated analyte value. 9. The method of claim 7, further comprising controlling a display of the sensor system based at least in part on a level of interferent detected on the second signal. 10. The method of claim 7, further comprising processing the first signal and the second signal to obtain a subtracted signal, wherein processing is based at least in part a level of interferent of the sensor system. 11. The method of claim 1, further comprising determining a level of reliability of the sensor system by comparing at least one of an amplitude, a change in amplitude, a signal waveform, or a change in a signal waveform of the second signal to one or more criteria. 12. The method of claim 11, further comprising controlling a display of the sensor system based at least in part on the level of reliability of the sensor system. 13. The method of claim 1, wherein evaluating comprises determining a success of a biological sample draw-back from a host's circulatory system to the analyte sensor. 14. The method of claim 13, further comprising displaying an analyte value measured during the biological sample draw-back in response to a determination of a successful biological sample draw-back. 15. A method for performing diagnostic of an analyte sensor system, comprising: providing a sensor system comprising an analyte sensor and a flow control device configured to intermittently expose the analyte sensor to a biological sample and an infusion solution, wherein the analyte sensor comprises: a first working electrode configured to provide a first signal comprising an analyte component and a baseline component; anda second working electrode configured to provide a second signal analyte component, comprising a baseline component substantially without an wherein the second signal comprises a signal waveform; andevaluating the sensor system, using a processor module, based at least in part on the second signal, wherein evaluating the sensor system comprises: (i) evaluating the signal waveform for at least one of an expected shape or a pattern when the analyte sensor is exposed to at least one of the biological sample or the infusion solution and (ii) evaluating at least one of a similarity or a correlation between the signal waveform and a waveform template, wherein the waveform template is based at least in part on a signal waveform measured by the sensor system. 16. A method for performing diagnostic of an analyte sensor system, comprising: providing a sensor system comprising an analyte sensor and a flow control device configured to intermittently expose the analyte sensor to a biological sample and an infusion solution, wherein the analyte sensor comprises: a first working electrode configured to provide a first signal comprising an analyte component and a baseline component; anda second working electrode configured to provide a second signal comprising a baseline component substantially without an analyte component, wherein the second signal comprises a signal waveform; andevaluating the sensor system, using a processor module, based at least in part on the second signal, wherein evaluating the sensor system comprises evaluating the signal waveform for at least one of an expected shape or a pattern when the analyte sensor is exposed to at least one of the biological sample or the infusion solution, wherein evaluating the signal waveform comprises evaluating a monotonicity of the signal waveform. 17. The method of claim 16, wherein evaluating a monotonicity of the signal waveform comprises performing a correlation waveform analysis of the signal waveform with the waveform template. 18. The method of claim 16, wherein evaluating a monotonicity of the signal waveform comprises performing a time-series analysis. 19. A method for performing diagnostic of an analyte sensor system, comprising: providing a sensor system comprising an analyte sensor and a flow control device configured to intermittently expose the analyte sensor to a biological sample and an infusion solution, wherein the analyte sensor comprises: a first working electrode configured to provide a first signal comprising an analyte component and a baseline component; anda second working electrode configured to provide a second signal comprising a baseline component substantially without an analyte component; andevaluating the sensor system, using a processor module, based at least in part on the second signal, wherein evaluating comprises determining a success of infusing the infusion solution such that the biological sample is washed from the sensor. 20. The method of claim 19, wherein determining a success of infusing comprises displaying an analyte value measured in the biological sample after infusing the infusion solution in response to a determination of a successful infusion.