Probablistic pharmacokinetic and pharmacodynamic modeling
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/168
G08B-001/08
출원번호
US-0260073
(2010-03-24)
등록번호
US-8480616
(2013-07-09)
국제출원번호
PCT/US2010/028518
(2010-03-24)
§371/§102 date
20110923
(20110923)
국제공개번호
WO2010/111403
(2010-09-30)
발명자
/ 주소
Robertson, Timothy
Behzadi, Yashar
출원인 / 주소
Proteus Digital Health, Inc.
대리인 / 주소
Bozicevic, Field & Francis LLP
인용정보
피인용 횟수 :
0인용 특허 :
266
초록▼
The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determina
The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.
대표청구항▼
1. A system comprising: a processor; andat least one memory, the processor and the at least one memory configured to provide a response determinator to:receive therapeutic and wellness data;determine, based on the received therapeutic and wellness data, a response representing a reaction to a substa
1. A system comprising: a processor; andat least one memory, the processor and the at least one memory configured to provide a response determinator to:receive therapeutic and wellness data;determine, based on the received therapeutic and wellness data, a response representing a reaction to a substance integrated with an ingestible event marker; and provide the determined response; andwherein the response determinator determines the response as a response matrix, H, according to the following equation: H=(ATA)−1ATY, wherein A represents one or more times that a dose of the substance is ingested, AT represents a transpose of matrix A, (AT A)−1 represents an inverse of a matrix multiplication of matrix A and matrix AT, and Y represents a matrix of observations including the therapeutic and wellness data. 2. The system of claim 1, wherein the therapeutic and wellness data includes ingestible event marker data received from the ingestible event marker integrated with the substance, the ingestible event marker providing a signal when the substance is ingested. 3. The system of claim 1, wherein the therapeutic and wellness data includes data representative of physiological aspects associated with the ingestion of the ingestible event marker and the substance. 4. The system of claim 1, wherein the therapeutic and wellness data includes one or more of the following: an ingestion time; an identification of the substance; an expiration date of the substance; a dosage amount for the substance; one or more physiological parameters associated with the reaction to at least one dose of the substance; a dosage of an intravenous substance; a heart rate; a blood pressure measurement; an optical measurement; a body temperature; a weight; an amount of an inhalant; an inhalation time; an identity of an inhaled substance; a galvanic skin response; an insertion time; and a drinking time. 5. The system of claim 1, wherein the response determinator determines the response as a function of the therapeutic and wellness data. 6. The system of claim 1 further comprising: a therapy controller configured to control, based on the response, at least one of an amount the substance and a time of the substance is ingested. 7. A system comprising: a processor; andat least one memory, the processor and the at least one memory configured to provide a therapy controller to: receive a response representing a reaction to a substance integrated with an ingestible event marker;receive therapeutic and wellness data; and control, based on the received response and the received therapeutic and wellness data, at least one of a dose of the substance and a time of the dose of the substance; wherein the response is determined as a response matrix, H, according to the following equation: H=(ATA)−1ATY, wherein A represents one or more times that a dose of the substance is ingested, AT represents a transpose of matrix A, (ATA)−1 represents an inverse of a matrix multiplication of matrix A and matrix AT, and Y represents a matrix of observations including the therapeutic and wellness data. 8. The system of claim 7, wherein the therapy controller uses a closed-loop to control at least one of the dose of the substance and the time of the dose of the substance. 9. The system of claim 7, wherein the therapy controller uses a closed-loop to vary an input to the response to generate an output of the response, the output corresponding to at least one of the dose of the substance and the time of the dose of the substance. 10. The system of claim 7, wherein the ingestible event marker data are received from the ingestible event marker integrated with the substance, the ingestible event marker providing a signal when the substance is ingested. 11. The system of claim 7, wherein the therapeutic and wellness data represents physiological aspects associated with the ingestion of the ingestible event marker and the substance. 12. The system of claim 7, wherein the response is determined based on the reaction of at least one of an individual patient, a population, and a subset of the population. 13. The system of claim 7, wherein the response is determined as a function of the therapeutic and wellness data.
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이 특허에 인용된 특허 (266)
Neil Brian K. (Issaquah WA), Abrasive skin electrode.
Kolter, Karl; Schonherr, Michael; Ascherl, Hermann, Active ingredient-containing floating forms comprising polyvinyl acetate and polyvinylpyrrolidone, their use and production.
Goscha,Donald L.; Haeder,Lisa D.; Kadhiresan,Veerichetty A.; Johnson,David C.; Srivathsa,Muralidharan; Brockway,Marina, Ambulatory repeater for use in automated patient care and method thereof.
Hayward, Roger; Fuller, Richard; Glissman, John; Marshall, Noel, Antenna design utilizing a cavity architecture for global positioning system (GPS) applications.
Cosentino, Louis C.; Duea, Michael John; Duea, Duane Robert; Dorfe, Steven George; Nubson, Richard C.; Cosentino, Judith A., Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients.
Cosentino, Daniel L.; Cosentino, Louis C.; Dorfe, Steven George; Duea, Duane Robert, Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients.
Sadri, Ali S.; Maltsev, Alexander; Maslennikov, Roman; Khoryaev, Alexey; Sergeyev, Vadim, Communication within a wireless network using multiple frequency bands.
Markki,Outi; Ekberg,Jan Erik; Kokkinenh,Heikki; Kuoppala,Mika, Content distribution & communication system for enhancing service distribution in short range radio environment.
Doi, Kenji; Hashimoto, Masaru; Koyama, Masaki; Suzuki, Yoshiko; Nishimura, Tokuhisa, Data transmission system using a human body as a signal transmission path.
Zacouto Fred (16 rue de la Convention 75 015 Paris FRX), Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemo.
Hugemann Berhhard (Frankfurt am Main DEX) Schuster Otto (Bad Soden DEX), Device for the release of substances at defined locations in the alimentary tract.
Caldwell Larry J. (Lawrence KS) Gardner Colin R. (Lawrence KS) Cargill Robyn C. (Lawrence KS), Drug delivery device which can be retained in the stomach for a controlled period of time.
Muehlsteff,Jens; Reiter,Harald; Montvay,Andras; Lauter,Josef; Such,Olaf; Schmidt,Ralf; Perkuhn,Michael; Kohler,Fabian, Electrode assembly and a system with impedance control.
Malick,Crista; Qi,Xie; Parikh,Mitesh; Franke,Steve; Jones,Douglas L.; Larsen,Jeffery B.; Schmitz,Christopher D.; Callias,Francois, Electrode placement for wireless intrabody communication between components of a hearing system.
Christophersom, Mark A.; Donders, Adrianus P.; Miesel, Keith A.; Twetan, Len D., Externally worn transceiver for use with an implantable medical device.
Thompson, David L.; Greeninger, Daniel R.; Goedeke, Steven D., Implantable medical device controlled by a non-invasive physiological data measurement device.
Vock Josef (Spanga SEX) Ljungstroem Jan (Solna SEX) Ekwall Christer (Spanga SEX), Implantable medical device with means for telemetric transmission of data.
Casper Robert A. (Raleigh NC) McCartney Michael L. (Durham NC) Jochem Warren J. (Cary NC) Parr Alan F. (Cary NC), Medical capsule device actuated by radio-frequency (RF) signal.
David L. Thompson ; Steven D. Goedeke, Medical management system integrated programming apparatus for communication with an implantable medical device.
Mazar,Scott T.; Manicka,Yatheendhar D., Method and apparatus for enabling data communication between an implantable medical device and a patient management system.
Lu, Kan; Jiang, Chongjun; Chen, Michael; Xu, Bin; Tang, Yiyan; Hong, Huiyong; Wu, Shuangli; Wu, Feng, Method and device for providing multiple communication protocols with a single transceiver.
King, Dennis; Astley, Ken; Tarassenko, Lionel; Anuzis, Paul; Hayton, Paul; King, Stephen, Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components.
Serpa,Mark; Alhemsi,Hani; Ratajski,Greg; Ashlock,Bob, Method and system for peer-to-peer wireless communication over unlicensed communication spectrum.
Lloyd Lindsay B. (West Jordan UT) Beck Jon E. (Salt Lake City UT) Petelenz Tomasz J. (Salt Lake City UT) Jacobsen Stephen C. (Salt Lake City UT), Method of making a hydratable bioelectrode.
Cofino Thomas Anthony ; Friedman Daniel Joseph ; Goldman Kenneth Alan ; Heinrich Harley Kent, Method of using write--ok flag for radio frequency (RF) transponders (RF Tags).
Haller,Amit; Fornell,Peter; Itzchak,Avraham; Haparnas,Ziv, Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network.
Haller, Amit; Haparnas, Ziv, Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network.
Heller,Adam; Mano,Nicholas; Kim,Hyug Han; Zhang,Yongchao; Mao,Fei; Chen,Ting; Barton,Scott Calabrese, Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods.
Francis A. Spelman ; Page Read ; N. Mani Prakash ; James A. Nelson ; Charles E. Pope ; Margaret Heitkemper ; James D. Rothermel, Non-invasive gut motility monitor.
Welch, James P.; Baker, Steven D.; Guilak, Farzin G.; Sampath, Anand; Williams, Daniel L., Personal status physiologic monitor system and architecture and related monitoring methods.
Ryu,Chang Yong; Kim,Seung Hwan; Kim,Youn Tae, Physiological signal detection module, multi-channel connector module and physiological signal detection apparatus using the same.
Ricks Robert D. (Newark CA) Bornn Robert (San Francisco CA) Hurt David B. (Mountain View CA), Portable, multi-channel, physiological data monitoring system.
Harrison, Christopher; Mullins, Oliver C.; Vancauwenberghe, Olivier; Donzier, Eric P.; Chikenji, Akihito; Goodwin, Anthony Robert Holmes; Pop, Julian J., Protective barriers for small devices.
Mastrocola Angelo R. (West Lawn PA) Sonntag Jeffrey L. (Rockland Township ; Berks County PA), Ring oscillator using even numbers of differential stages with current mirrors.
Atkinson Linda E. (Portola Valley CA) Dunn John T. (Palo Alto CA) Gale Robert M. (Los Altos CA) Rivera David L. (San Jose CA), Segmented device for simultaneous delivery of multiple beneficial agents.
Yasuda,Mitsuyoshi; Itoh,Katsutoshi; Natori,Makoto; Yokoshi,Minoru; Yoshimura,Osamu; Itagaki,Takeshi, Short range wireless communication system, portable terminal apparatus, and wireless communication apparatus.
Teller, Eric; Stivoric, John M.; Kasabach, Christopher D.; Pacione, Christopher D.; Moss, John L.; Liden, Craig B.; McCormack, Margaret A., System for monitoring health, wellness and fitness.
Stivoric, John M.; Moss, John L.; Kasabach, Christopher D.; Boehmke, Scott K.; Zaremsky, Mark; Sica, Vanessa, System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow.
Nolan Michael P. (Elk Grove IL), System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages usin.
Salazar Joe Andrew ; Molero-Castro Luis,ESX, Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception.
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