IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0063291
(2006-08-28)
|
등록번호 |
US-8480757
(2013-07-09)
|
국제출원번호 |
PCT/US2006/033687
(2006-08-28)
|
§371/§102 date |
20081210
(20081210)
|
국제공개번호 |
WO2007/025290
(2007-03-01)
|
발명자
/ 주소 |
- Gage, Gary
- Adkisson, IV, H. Davis
- Blanchard, Cheryl R.
|
출원인 / 주소 |
|
대리인 / 주소 |
Schwegman, Lundberg & Woessner P.A.
|
인용정보 |
피인용 횟수 :
13 인용 특허 :
362 |
초록
▼
Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or dis
Implants comprising cartilage and trabecular metal, and methods of making the implants are disclosed. Further disclosed are therapeutic uses of the implants, which include methods of treatment or repair of an chondral or osteochondral defect, such as a chondral or osteochondral injury, lesion or disease. An implant comprises cartilage or chondrocytes and a subchondral base comprising trabecular metal. An implant can comprise a geometric shape such as a cylinder or an anatomical shape such as a condyle, and can be used in conjunction with a positioning structure.
대표청구항
▼
1. An implant for administering to a patient in need of treatment for joint disease, defect or injury, the implant comprising: minced juvenile cartilage tissue from a human cadaveric donor; anda subchondral base comprising at least one trabecular metal. 2. The implant of claim 1 wherein the cartilag
1. An implant for administering to a patient in need of treatment for joint disease, defect or injury, the implant comprising: minced juvenile cartilage tissue from a human cadaveric donor; anda subchondral base comprising at least one trabecular metal. 2. The implant of claim 1 wherein the cartilage tissue comprises articular cartilage. 3. The implant of claim 2 wherein the cartilage tissue and the subchondral base are attached. 4. The implant of claim 1, wherein the subchondral base further comprises at least one porous surface layer and a porous core, the at least one porous surface layer comprising a plurality of pores of median diameter from about 3 microns to about 800 microns wherein the median diameter of the plurality of pores of the at least one porous surface layer is different from that of the plurality of pores of the core of the subchondral base. 5. The implant of claim 1, wherein the subchondral base comprises at least two surfaces, wherein a first surface comprises trabecular metal comprising a plurality of pores having a median pore diameter of from about 100 microns to about 800 microns, and a second surface which is a cartilage-adherent surface. 6. The implant of claim 5, wherein the cartilage-adherent surface comprises a plurality of pores of median diameter from about 3 microns to about 800 microns. 7. The implant of claim 5, wherein the cartilage-adherent surface comprises a cartilage adhesive. 8. The implant of claim 7, wherein the cartilage adhesive comprises a hydrogel. 9. The implant of claim 7, wherein the cartilage-adhesive comprises trans-glutaminase, hyaluronic acid, collagen, fibrin, albumin, elastin or silk. 10. The implant of claim 9, wherein the cartilage adhesive comprises fibrin. 11. The implant of claim 1 wherein the trabecular metal comprises tantalum, niobium, stainless steel, chromium-cobalt alloy or titanium. 12. The implant of claim 11 wherein the trabecular metal comprises tantalum. 13. The implant of claim 1 wherein the subchondral base is cylindrical. 14. The implant of claim 1 wherein the subchondral base approximates the anatomical shape of a human condyle, hemi-condyle, acetabulum or femoral head. 15. A kit for forming the implant of claim 1, the kit comprising: an amount of the cartilage tissue;the subchondral base comprising at least one trabecular metal; andpackaging for the cartilage tissue and the subchondral bone. 16. The kit of claim 15 further comprising a cartilage adhesive. 17. The kit of claim 15 wherein the subchondral base is packaged separately from the cartilage tissue and cartilage adhesive. 18. A method of treating joint disease, defect or injury in a patient in need thereof comprising: introducing into the patient a subchondral base comprising at least one trabecular metal, wherein the subchondral base is configured to receive cartilage tissue; andapplying minced juvenile cartilage tissue from a human cadaveric donor to the subchondral base. 19. The method of claim 18 wherein the cartilage tissue is applied to the subchondral base after introducing the subchondral base into the patient. 20. The method of claim 19, wherein applying comprises attaching the cartilage tissue to a surface of the subchondral base. 21. The method of claim 20, wherein attaching comprises applying a cartilage adhesive to an interface between a surface of the subchondral base and a surface of the cartilage tissue prior to contacting the cartilage tissue with the surface of the subchondral base. 22. The method of claim 18 wherein the cartilage tissue comprises articular cartilage. 23. The method of claim 22, further comprising coupling the subchondral base to a positioning structure. 24. The method of claim 23, wherein the positioning structure comprises a non-trabecular metal. 25. The method of claim 23, wherein the positioning structure comprises a biocompatible polymer. 26. The method of claim 23, wherein the positioning structure comprises a screw, cylinder, plat, rod or washer. 27. The method of claim 18 wherein the subchondral base comprises at least one porous surface layer comprising a plurality of pores of median diameter from about 3 microns to about 800 microns and wherein the median diameter of the plurality of pores of the at least one porous surface layer is different from that of the plurality of pores of the subchondral base. 28. The method of claim 27 wherein the at least one porous surface layer comprises a plurality of pores of median pore diameter of about 100 microns to about 800 microns. 29. The method of claim 18, wherein the subchondral base comprises at least two surfaces, wherein a first surface comprises the trabecular metal having a plurality of pores there through, the pores having a median pore diameter of from about 100 microns to about 800 microns, and a second surface which is a cartilage-adherent surface. 30. The method of claim 18, wherein applying comprises attaching the cartilage tissue to a surface of the subchondral base with a fibrin adhesive. 31. The method of claim 18, wherein the subchondral base is cylindrical. 32. The method of claim 18, wherein the at least one trabecular metal comprises tantalum. 33. A method of forming an implant comprising cartilage and a subchondral base comprising: obtaining a subchondral base comprising at least one trabecular metal; andcontacting the subchondral base with minced juvenile cartilage tissue from a human cadaveric donor. 34. The method of claim 33, further comprising coupling the cartilage tissue to a surface of the subchondral base. 35. The method of claim 34, wherein coupling comprises applying a cartilage adhesive to an interface between a surface of the subchondral base and a surface of the cartilage tissue prior to contacting the cartilage tissue with the subchondral base. 36. The method of claim 34, wherein coupling comprises attaching the cartilage tissue to a surface of the subchondral base with a fibrin adhesive. 37. The method of claim 33 wherein the implant further comprises at least one porous surface layer comprising a plurality of pores of median diameter from about 3 microns to about 800 microns wherein the median diameter of the plurality of pores of the at least one porous surface layer is different from that of the plurality of pores of the subchondral base. 38. The method of claim 33 wherein the subchondral base comprises at least two surfaces, wherein a first surface comprises trabecular metal comprising a plurality of pores having a median pore diameter of from about 100 microns to about 800 microns, and a second surface which is a cartilage-adherent surface comprising a plurality of pores having a median diameter from about 3 microns to about 20 microns. 39. The method of claim 38 wherein the cartilage-adherent surface comprises a resorbable polymer. 40. The method of claim 33, wherein the cartilage tissue comprises articular cartilage. 41. The method of claim 33, wherein the at least one trabecular metal comprises tantalum. 42. The method of claim 33, wherein the subchondral base is cylindrical.
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