Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-009/08
A61K-047/00
A61K-047/30
A61K-009/00
A61F-013/02
출원번호
US-0279982
(2011-10-24)
등록번호
US-8481073
(2013-07-09)
발명자
/ 주소
Daniloff, George Y.
Sehl, Louis C.
Trollsas, Olof Mikael
Schroeder, Jacqueline A.
Gravett, David M.
Toleikis, Philip M.
출원인 / 주소
AngioDevice International GmbH
대리인 / 주소
Seed IP Law Group PLLC
인용정보
피인용 횟수 :
5인용 특허 :
198
초록▼
Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable in
Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.
대표청구항▼
1. A method of preventing adhesions between tissues of a patient, comprising: (a) providing a dry powder composition including: i. a first component having a first hydrophilic polymer core substituted with m thiol groups, where m≧2; andii. a second component having a second hydrophilic polymer core
1. A method of preventing adhesions between tissues of a patient, comprising: (a) providing a dry powder composition including: i. a first component having a first hydrophilic polymer core substituted with m thiol groups, where m≧2; andii. a second component having a second hydrophilic polymer core substituted with n electrophilic groups, where n≧2 and m+n>4, and wherein the electrophilic group is independently —(CO)—O—(CO)—R (where R is an alkyl group), CH═CH—CH═O, —CH═CH—C(CH3)═O, —N═C═O, —N═C═S, —SO2CH═CH2, —O(CO)—C═CH2, —(CO)—C(CH3)═CH2, —S—S—(C5H4N), —O(CO)—C(CH2CH3)═CH2, —CH═CH—C═NH, —COOH, —(CO)O—N(COCH2)2, —O—(CO)—O—N(COCH2)2, —CHO, —(CO)O—N(COCH2)2—S(O)2OH, and —N(COCH)2;(b) rendering the nucleophilic and electrophilic groups reactive by exposing the composition to an aqueous environment to effect inter-reaction; wherein said exposure comprises: (i) dissolving the dry powder composition in a first solution having a pH within the range of about 2.1-2.3 to form a homogeneous solution, and(ii) adding a second solution having a pH within the range of about 6.0 to 11.0 to the homogeneous solution to form a mixture; and(c) placing the mixture into contact with tissue and allowing a three-dimensional composition to form on the tissue. 2. The method of claim 1, wherein the first hydrophilic polymer core and the second hydrophilic polymer core are independently a linear, branched, dendrimeric, hyperbranched, or star polymer. 3. The method of claim 2, wherein the first hydrophilic polymer core and the second hydrophilic polymer core are independently selected from polyalkylene oxides; polyols; poly(oxyalkylene)-substituted diols and polyols; polyoxyethylated sorbitol; polyoxyethylated glucose; poly(acrylic acids), analogs and copolymers thereof; polymaleic acids; polyacrylamides; poly(olefinic alcohols); poly(N-vinyl lactams); polyoxazolines; polyvinylamines; and copolymers thereof 4. The method of claim 3, wherein the first hydrophilic polymer core and the second hydrophilic polymer core are independently a polyalkylene oxide or a polyol selected from polyethylene glycol and poly(ethylene oxide)-poly(propylene oxide) copolymers. 5. The method of claim 4, wherein the hydrophilic polymer is a poly(oxyalkylene)-substituted polyol, wherein the polyol is selected from mono-, di- and tri-polyoxyethylated glycerol, mono- and di-polyoxyethylated propylene glycol, mono- and di-polyoxyethylated trimethylene glycol, and pentaerythritol. 6. The method of claim 1 further comprising delivering a biologically active agent with the mixture. 7. The method of claim 6, wherein the biologically active agent is a part of the dry powder composition. 8. The method of claim 6, wherein the biologically active agent is a part of the first solution. 9. The method of claim 6, wherein the biologically active agent is a part of the second solution. 10. The method of claim 6 wherein the biologically active agent is an anti-fibrotic agent.
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이 특허에 인용된 특허 (198)
Cooper Kevin (Warren NJ) Scopelianos Angelo (Whitehouse Station NJ), Absorbable polyalkylene diglycolates.
Fox Adrian S. (New Windsor NY) Czap Christine A. (Montgomery NY) Wiser Robin R. (Chester NY), Adhesive hydrogels having extended use lives and process for the preparation of same.
Yeung Jeffrey E. (San Jose CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Rhee Woonza M. (Palo Alto CA), Anti-adhesion films and compositions for medical use.
Thompson Keith P. (4548 E. Brookhaven Dr. Atlanta GA 30319) Liu Yung S. (2201 Pineridge Ct. Schenectady NY 12309) Banks Seth R. (9459 N. Fairway Cir. Milwaukee WI 53217) Gailitis Raymond P. (2107 N. , Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction.
Thompson Keith P. (4584 E. Brookhaven Dr. Atlanta GA 30319), Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction.
Thompson Keith P. (4584 E. Brookhaven Dr. Atlanta GA 30319), Apparatus and process for application and adjustable reprofiling of synthetic lenticules for vision correction.
Tardy Michel (Lyons FRX) Tiollier Jerome (Lyons FRX) Tayot Jean-Louis (La Tour De Salvagny FRX), Biocompatible bioresorbable and non-toxic adhesive composition for surgical use.
Silver Frederick A. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Birk David E. (Somerset NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Somerset NJ), Biodegradable matrix and methods for producing same.
Siiman Olavi (Davie FL) Burshteyn Alexander (Miami Lakes FL) Gupta Ravinder K. (Pembroke Pines FL), Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes f.
Juergensen Kay (Murten CHX) Aeschlimann Daniel (Basel CHX) Hunziker Ernst B. (Riedholz CHX), Biological adhesive composition and method of promoting adhesion between tissue surfaces.
Kelman Charles D. (New York NY) DeVore Dale P. (Chelmsford MA), Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom.
Kelman Charles D. (New York NY) Devore Dale P. (Chelmsford MA), Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Collombel Christian (Lyon FRX) Damour Odile (Saint Genis Laval FRX) Gagnieu Christian (Lyon FRX) Poinsignon Frederique (Lyon FRX) Echinard Christian (Gemenos FRX) Marichy Jacques (Lyon FRX), Biomaterials with a base of mixtures of collagen, chitosan and glycosaminoglycans, process for preparing them and their.
Adams Steven W. (Sunnyvale CA) Armstrong Rosa (Palo Alto CA) Rosen David (San Jose CA), Bone growth factors and inhibitors of bone resorption for promoting bone formation.
Deibig Heinrich (Frankfurt am Main Schwalbach DEX) Heide Helmut (Schwalbach DEX) Reiner Roland (Eschborn DEX) Koster Kari (Lorsbach DEX), Bone replacement or prosthesis anchoring material.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA), Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications.
Miyata Teruo (Tokyo NJ JPX) Rubin Albert L. (Englewood NJ) Stenzel Kurt H. (Englewood NJ) Dunn Michael W. (New Rochelle NY), Collagen drug delivery device.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Stol Miroslav (Prague CSX) Tolar Miroslav (Prague CSX) Adam Milan (Prague CSX) Cefelin Pavel (Prague CSX) Kalal Jaroslav (Prague CSX), Composite polymeric material for biological and medical application and the method for its preparation.
Shalaby Shalaby W. (Lebanon NJ) Stephenson Martin (Peterborough CAX) Schaap Louise (Peterborough CAX) Hartley ; deceased Graham H. (late of Peterborough CAX By Marilyn Hartley ; personal representati, Composite sutures of silk and hydrophobic thermoplastic elastomers.
Dorman Linneaus C. (Midland MI) Meyers Paul A. (Dublin CA), Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Composition for bone repair.
Palefsky Howard (Atherton CA) Pharriss Bruce B. (Palo Alto CA) Chu George (Cupertino CA), Composition of low type III content human placental collagen.
Olof Mikael Trollsas ; Donald G. Wallace ; Frank A. DeLustro, Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use.
Donald G. Wallace ; George H. Chu ; Jacqueline Anne Schroeder, Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use.
Shadle Paula J. (Richmond CA) Koths Kirston E. (El Cerrito CA) Moreland Margaret (Berkeley CA) Katre Nandini (El Cerrito CA), Conjugation of polymer to colony stimulating factor-1.
Braatz James A. (Rockville MD) Kehr Clifton L. (Silver Spring MD), Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers.
Balazs Endre A. (Ft. Lee NJ) Leshchiner Adolf (Fairview NJ) Larsen Nancy E. (Ridgefield Park NJ), Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same.
Smestad Thomas L. (Palo Alto CA) Prows Daniel (Santa Clara CA) Chu George H. (Sunnyvale CA) Hendricks Diana M. (Brea CA), Gamma irradiation of collagen/mineral mixtures.
Soon-Shiong Patrick (Los Angeles CA) Desai Neil P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha A. (Los Angeles CA) Sojomihardjo Soebianto (Pasadena CA), Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
Cartmell James V. (Xenia) Sturtevant Wayne R. (Centerville) Wolf Michael L. (West Milton) Allaire Michael J. (Cincinnati OH), High absorbency hydrogel wound dressing.
Balazs Endre A. (Ft. Lee NJ) Leshchiner Adolf (Fairview NJ) Leshchiner Adelya (Fairview NJ) Larsen Nancy (Southfield NY) Band Philip (Brooklyn NY), Hylan preparation and method of recovery thereof from animal tissues.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Wilk Peter J. (185 W. End Ave. New York NY 10023) Cinberg James Z. (167 N. Ridgewood Rd. South Orange NJ 07079), Method and surgical instrument for repairing hernia.
Ogawa Yasushi (Pacifica CA) Schmidt David K. (Santa Cruz CA) Armstrong Rosa (Palo Alto CA) Nathan Ranga (Newark CA) Thompson Andrea Y. (Mountain View CA) Seyedin Saeid M. (Saratoga CA), Method for inducing bone growth.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue with collagen-polymer conjugates.
Mosbach Klaus H. (Furulund SEX) Nilsson Kurt G. I. (Lund SEX), Method of covalently binding biologically active organic substances to polymeric substances.
Nesburn Anthony B. (Malibu CA) Gorin Michael (Rockville MD) Martinez Marvin (Glendale CA) Kenney M. Cristina (Malibu CA) Maguen Ezra (Los Angeles CA), Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers.
Burgess, Willson H.; Greisler, Howard P.; Drohan, William N.; Maciag, Thomas; MacPhee, Martin J., Method of preparing a tissue sealant-treated biomedical material.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. ; Rao Prema R. ; Chu George H. ; DeLustro Frank A. ; Harner Carol F. H. ; Sakai Naomi ; Schroeder Jacqueline A., Method of preventing formation of adhesions following surgery.
Liu Yung S. (Niskayuna NY) Thompson Keith P. (Atlanta GA) Gailitis Raymond P. (Decatur GA) Banks Seth R. (Milwaukee WI) Taylor Gary C. (Fair Oaks CA), Methods and lenticules for modifying the cornea.
Franz Helmut (Biberach DEX) Muller Thomas (Biberach DEX) Eisert Wolfgang (Biberach DEX), Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydrox.
Sehl, Louis C.; Trollsas, Olof Mikael; Wallace, Donald G.; Toman, David; DeLustro, Frank A.; Schroeder, Jacqueline A.; Chu, George H., Methods for tissue repair using adhesive materials.
Wallace Donald G. (Menlo Park CA) Smestad Thomas L. (Palo Alto CA) McPherson John M. (Sunnyvale CA) Piez Karl A. (Menlo Park CA) Seyedin Saeid (Sunnyvale CA) Armstrong Rosa (Palo Alto CA), Methods of bone repair using collagen.
Jiang Ying (North Haven CT) Gruskin Elliott A. (Killingworth CT), Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom.
Cioca Gheorge (Coatesville PA) Feeley George F. (Downingtown PA) Brabson Joseph B. (Wilmington DE) Barth Peter (Neuwied DEX), Moisture vapor permeable sheet materials.
Luck Edward E. (216 Robin Way Menlo Park CA 94025) Daniels John R. (842 Las Casas Pacific Palisades CA 90272), Non-antigenic collagen and articles of manufacture.
Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
Constancis Alain (Lyons FRX) Soula Gerard (Meyzieu FRX), Organic products containing reactive thiol functions, one method for preparing same, and biomaterials containing said pr.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Daniels John R. (Menlo Park CA) Knapp Terry R. (Santa Clara CA), Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
Wallace, Donald G.; Cruise, Gregory M.; Rhee, Woonza M.; Schroeder, Jacqueline Anne; Coker, III, George T.; Maroney, Marcee M.; Trollsas, Olof Mikael, Rapid-gelling biocompatible polymer composition and associated methods of preparation and use.
Carlsson Jan P. E. (Uppsala SEX) Axen Rolf E. A. V. (Balinge SEX) Drevin Hakan N. Y. (Brunna SEX) Lindgren Goran E. S. (Almunge SEX), Reactive derivatives of HS-group-containing polymers.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Fort Lee NJ) Eaton Alexander M. (Durham NC), Tissue bonding and sealing composition and method of using the same.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Regula Donald W. (Belle Mead NJ) Cooper Kevin (Warren NJ) Bregen Michael F. (Milford NJ) Huxel Shawn T. (Lakehurst NJ) Rosenman Daniel C. (San Mateo CA), Utilization of biocompatible adhesive/sealant materials for securing surgical devices.
Devore Dale P. (Chelmsford MA) Scherrer Robert A. (White Bear Lake MN) Scholz Matthew T. (Woodbury MN), Viscoelastic collagen solution for opthalmic use and method of preparation.
Hamilton Raymond (Somerville MA) Fox Ellen M. (Cranston RI) Acharya Raksha A. (Northboro MA) Walts Alan E. (Brookline MA), Water insoluble derivatives of hyaluronic acid.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Xenogeneic collagen/mineral preparations in bone repair.
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