초록 ▼

This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection l

This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.

대표청구항 ▼

1. A system comprising: an implantable thoracic impedance measurement circuit configured to sense a thoracic impedance signal from a subject;a parameter collection device configured to sense or receive physiologic information about the subject, the physiologic information including heart wall motion

1. A system comprising: an implantable thoracic impedance measurement circuit configured to sense a thoracic impedance signal from a subject;a parameter collection device configured to sense or receive physiologic information about the subject, the physiologic information including heart wall motion, the parameter collection device including a heart wall dyssynchrony measurement device, wherein the heart wall dyssynchrony measurement device is configured to sense a first heart wall motion signal from a first cardiac site and a second heart wall motion signal from a second cardiac site, and wherein the parameter collection device is configured to provide a heart wall dyssynchrony signal indicative of the heart wall motion from a phase difference between the first heart wall motion signal and the second heart wall motion signal; anda pulmonary edema indicator coupled with the thoracic impedance measurement circuit to accept the thoracic impedance signal and coupled with the parameter collection device to accept the heart wall dyssynchrony signal, wherein the pulmonary edema indicator is configured to provide a pulmonary edema indication using the thoracic impedance signal and the heart wall dyssynchrony signal. 2. The system of claim 1, comprising a posture sensor adapted to sense a posture signal, the posture sensor being coupled with the pulmonary edema indicator, wherein the pulmonary edema indicator is configured to provide a pulmonary edema indication using the posture signal. 3. The system of claim 2, comprising a posture compensation module configured to compute a posture-compensated thoracic impedance signal from the thoracic impedance signal using the posture signal, wherein the pulmonary edema indicator is configured to determine the pulmonary edema indication using, at least in part, the posture-compensated thoracic impedance signal. 4. The system of claim 1, wherein: the pulmonary edema indicator determines the pulmonary edema indication when the thoracic impedance signal is less than a thoracic impedance threshold; andthe pulmonary edema indicator includes a threshold adjustment module adapted to adjust the thoracic impedance threshold using, at least in part, the physiologic information driven by the presence or absence of pulmonary edema. 5. The system of claim 1, comprising a frequency selective filter circuit configured to extract from the thoracic impedance signal a near-DC thoracic impedance signal. 6. The system of claim 1, comprising: a blood impedance measurement circuit configured to sense a blood impedance signal from the subject; anda blood impedance correction module coupled with the blood impedance measurement circuit, wherein the blood impedance correction module is configured to extract from the thoracic impedance signal a blood resistivity-influenced component using the blood impedance signal, and wherein the pulmonary edema indicator is adapted to determine the pulmonary edema indication using, at least in part, a blood resistivity-compensated thoracic impedance signal. 7. The system of claim 1, comprising a therapy control module coupled to the pulmonary edema indicator, wherein the therapy control module is configured to adjust or initiate a therapy based, at least in part, on the pulmonary edema indication, and wherein the therapy includes at least one of: cardiac rhythm management therapy, dietary therapy, and breathing assistance therapy. 8. A method comprising: implantably sensing a thoracic impedance signal from the thorax of a subject;sensing or receiving physiologic information about the subject, the physiologic information including heart wall motion, wherein sensing or receiving the physiologic information includes: sensing a first heart wall motion signal from a first cardiac site and a second heart wall motion signal from a second cardiac site; andproviding a heart wall dyssynchrony signal indicative of the heart wall motion from a phase difference between the first heart wall motion signal and the second heart wall motion signal; anddetermining, using a processor circuit, a pulmonary edema indication using the thoracic impedance signal and the heart wall dyssynchrony signal, wherein determining the pulmonary edema indication includes comparing the thoracic impedance signal to a thoracic impedance threshold. 9. The method of claim 8, comprising sensing a posture signal corresponding to the posture of the subject, wherein determining, using the processor circuit, the pulmonary edema indication includes using the sensed posture signal. 10. The method as recited in claim 9, comprising one or more of: filtering the thoracic impedance signal to obtain a near-DC thoracic impedance signal, compensating the thoracic impedance signal to attenuate or remove a posture-influenced component of the thoracic impedance signal, and compensating the thoracic impedance signal to attenuate or remove a blood resistivity-influenced component of the thoracic impedance signal, wherein determining the pulmonary edema indication includes comparing one or a combination of: the near-DC thoracic impedance signal, a posture-compensated thoracic impedance signal, and a blood resistivity-compensated thoracic impedance signal, to the thoracic impedance threshold. 11. The method as recited in claim 8, comprising: increasing the sensitivity of the pulmonary edema indication, including computing a change in the thoracic impedance threshold using the physiologic information;adjusting the thoracic impedance threshold using the computed change; anddetermining the pulmonary edema indication with increased sensitivity using an adjusted thoracic impedance threshold. 12. The method as recited in claim 8, comprising alerting a user in response to the pulmonary edema indication. 13. The method as recited in claim 8, comprising providing a therapy to the subject in response to the pulmonary edema indication, wherein the therapy includes one or a combination of: cardiac rhythm management therapy, dietary therapy, and sleep disordered breathing therapy. 14. A system comprising: means for implantably sensing a thoracic impedance signal from the thorax of a subject;means for sensing or receiving physiologic information about the subject, the physiologic information including heart wall motion, wherein the means for sensing or receiving the physiologic information includes:means for sensing a first heart wall motion signal from a first cardiac site and a second heart wall motion signal from a second cardiac site to provide a heart wall dyssynchrony signal indicative of the heart wall motion from a phase difference between the first heart wall motion signal and the second heart wall motion signal; andmeans for determining a pulmonary edema indication using the thoracic impedance signal and the heart wall dyssynchrony signal, wherein the means for determining the pulmonary edema indication includes means for comparing the thoracic impedance signal to a thoracic impedance threshold.