IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0630627
(2003-07-29)
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등록번호 |
US-8486426
(2013-07-16)
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발명자
/ 주소 |
- Maley, Joseph C.
- Gibbins, Bruce L.
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출원인 / 주소 |
- Kimberly-Clark Worldwide, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
137 |
초록
▼
The present invention comprises methods and compositions for the treatment of pathological conditions of the dermis and dermal structures of animals and humans. In particular, the present invention comprises the use of topical delivery vehicles, including hydrogels, which incorporate active agents s
The present invention comprises methods and compositions for the treatment of pathological conditions of the dermis and dermal structures of animals and humans. In particular, the present invention comprises the use of topical delivery vehicles, including hydrogels, which incorporate active agents such as organic acids, for the treatment of dermal conditions.
대표청구항
▼
1. A method of treating a ungual condition comprising, a) applying to an ungual structure a composition comprising: a hydrophilic polymer matrix, wherein the hydrophilic polymer matrix includes a cross-linked polyacrylamide; at least one active agent, wherein the at least one active agent comprises
1. A method of treating a ungual condition comprising, a) applying to an ungual structure a composition comprising: a hydrophilic polymer matrix, wherein the hydrophilic polymer matrix includes a cross-linked polyacrylamide; at least one active agent, wherein the at least one active agent comprises a citric acid present at a concentration of from about 0.1% w/w to about 16% w/w; at least one humectant, wherein the humectant is present at a concentration of from about 15% to about 25w/w, further wherein in humectant includes glycerol; a moisture management system, wherein the moisture management system includes a non-gellable polysaccharide, wherein the non-gellable polysaccharide comprises guar gum, lucerne, fenugreek, honey locust bean gum, white clover bean gum, or carob locust bean gum; a moisture content ranging from 0.1% to 50% to create a diffusion gradient from the composition to the ungual structure, wherein the hydrophilic polymer matrix directly contacts the ungual structure, wherein moisture and the at least one active agent are transferred by the diffusion gradient from the hydrophilic polymer matrix composition to the ungual structure; and an open pattern adhesive, wherein the open pattern adhesive comprises a polvsiloxane, a polyisobutylene, a polyacrylate, an acrylic acid-acrylate copolymer, a polyisobutene, a polybutadiene, a polystyrene-isoprene copolymer, a polystyrene-butadiene copolymer, a neoprene, a polyacrylic acid, a polymethacrylic acid, or a blend of a hydrophilic cellulose derivative with a polyethylene glycol; andb) maintaining the composition at the ungual structure site for a sufficient amount of time so that an effective amount of the active agent is delivered. 2. The method of claim 1, wherein the citric acid is present at in a concentration between 4% w/w and 16% w/w. 3. An antifungal nail treatment composition comprising, a) a solid matrix sheet comprising a hydrophilic polymer matrix, wherein the hydrophilic polymer matrix includes a cross-linked polyacrylamide;b) at least one active antifungal agent, wherein the at least one active agent comprises a citric acid present at a concentration of from about 0.1% w/w to about 16% w/w;c) at least one humectant, wherein the humectant is present at a concentration of from about 15% w/w to about 25% w/w, further wherein the humectant includes glycerol;d) a moisture management system, wherein the moisture management system includes a non-gellable polysaccharide, wherein the non-gellable polysaccharide comprises guar gum, lucerne, fenugreek, honey locust bean gum, white clover bean gum, or carob locust bean gum;e) a moisture content ranging from 0.1% to 50% to create a diffusion gradient from the composition to an ungual structure, wherein moisture and the at least one active agent are transferred from the hydrophilic polymer matrix composition to the ungual structure when the composition contacts the ungual structure; andf) an open pattern adhesive, wherein the open pattern adhesive comprises a polysiloxane, a polyisobutylene, a polyacrylate, an acrylic acid-acrylate copolymer, a polyisobutene, a polybutadiene, a polystyrene-isoprene copolymer, a polystyrene-butadiene copolymer, a neoprene, a polyacrylic acid, a polymethacrylic acid, or a blend of a hydrophilic cellulose derivative with a polyethylene glycol. 4. The composition of claim 3, wherein the citric acid is present at in a concentration of from about 8% to about 16% w/w. 5. The composition of claim 3, wherein the composition inhibits the growth of fungi in a zone of inhibition of up to about 12millimeters. 6. The composition of claim 5, wherein the fungi comprises trichophyton, epidermophyton, microsporum, or combinations thereof.
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