An antimicrobial wipe that contains a polymer coating having a synergistic combination of ingredients for providing controlled release of an antimicrobial agent and also good antimicrobial efficacy is provided. One such ingredient is a high molecular weight polyamideamine release agent. Due to the p
An antimicrobial wipe that contains a polymer coating having a synergistic combination of ingredients for providing controlled release of an antimicrobial agent and also good antimicrobial efficacy is provided. One such ingredient is a high molecular weight polyamideamine release agent. Due to the polycationic nature of the release agent, it is able to adhere to the wipe, which is generally formed from fibers having a negative surface charge (e.g., cellulosic fibers). In this manner, the release agent can occupy binding sites on the wipe to inhibit the antimicrobial agent from adhering thereto, thus allowing it to be expressed in the germicidal solution to kill microbes on the desired surface. The adherence of the release agent to the wipe is even further enhanced by crosslinking the polyamideamine to increase its molecular weight, thereby enabling it to form a structural network that physically adheres to the wipe and that blocks the antimicrobial agent from binding thereto. Furthermore, the polyamideamine is amidated so that it contains secondary and/or tertiary amides. A cell permeabilizer is also employed in the polymer coating to enhance the efficacy of the antimicrobial agent during use. More particularly, polycationic materials are particularly useful in permeabilizing the outer cell membrane without adversely impacting the ability of the polyamideamine to release the antimicrobial agent within the wipe.
대표청구항▼
1. A wipe for use with a germicidal solution, wherein the wipe comprises a fibrous substrate impregnated with a germicidal solution containing an anti-microbial quaternary ammonium compound and further comprises a polymer coating disposed onto the fibrous substrate, the polymer coating containing a
1. A wipe for use with a germicidal solution, wherein the wipe comprises a fibrous substrate impregnated with a germicidal solution containing an anti-microbial quaternary ammonium compound and further comprises a polymer coating disposed onto the fibrous substrate, the polymer coating containing a release agent and a cell permeabilizer, wherein the release agent includes a crosslinked polyamideamine and the cell permeabilizer includes a polycationic substance, wherein the crosslinked polyamideamine has a weight average molecular weight of about 1,000,000 to about 2,000,000 grams per mole and the polycationic substance has a weight average molecular weight of about 600,000 to about 1,000,000 grams per mol, and wherein the ratio of the weight average molecular weight of the crosslinked polyamideamine to the weight average molecular weight of the polycationic substance is greater than 1 to about 3. 2. The wipe of claim 1, wherein the polyamideamine is formed from a polyalkylenepolyamine prepolymer. 3. The wipe of claim 2, wherein the polyalkylenepolyamine is polyethyleneimine. 4. The wipe of claim 2, wherein the polyalkylenepolyamine is a polyamine that is grafted with ethyleneimine. 5. The wipe of claim 2, wherein the prepolymer is crosslinked with a polyfunctional crosslinking agent. 6. The wipe of claim 5, wherein the crosslinking agent includes a monoethylenically unsaturated carboxylic acid, or an ester, amide, or anhydride thereof. 7. The wipe of claim 1, wherein the polyamideamine is alkoxylated. 8. The wipe of claim 1, wherein the ratio of the weight average molecular weight of the crosslinked polyamideamine to the weight average molecular weight of the polycationic substance is from about 1.2 to about 1.8. 9. The wipe of claim 1, wherein the polycationic substance is a polyamine. 10. The wipe of claim 9, wherein the polyamine is a crosslinked polyamideamine. 11. The wipe of claim 1, wherein the weight ratio of the cell permeabilizer to the release agent is from about 2 to about 10. 12. The wipe of claim 1, wherein the cell permeabilizer constitutes from about 60 wt. % to about 95 wt. % of the coating and the release agent constitutes from about 5 wt. % to about 40 wt. % of the coating. 13. The wipe of claim 1, wherein the solids add-on level of the polymer coating is from about 0.5% to about 15%. 14. The wipe of claim 1, wherein the fibrous substrate contains absorbent fibers. 15. The wipe of claim 14, wherein the absorbent fibers include cellulosic fibers. 16. The wipe of claim 15, wherein the cellulosic fibers include pulp fibers. 17. The wipe of claim 14, wherein the fibrous substrate is a composite that contains the absorbent fibers and synthetic thermoplastic fibers. 18. A method for disinfecting a surface, the method comprising contacting the surface with a wipe impregnated with a germicidal solution so that the solution is expressed therefrom, wherein the germicidal solution comprises an antimicrobial quaternary ammonium compound, and wherein the wipe comprises a fibrous substrate on which is disposed a polymer coating, the polymer coating containing a release agent and a cell permeabilizer, wherein the release agent includes a crosslinked polyamideamine and the cell permeabilizer includes a polycationic substance, wherein the crosslinked polyamideamine has a weight average molecular weight of about 1,000,000 to about 2,000,000 grams per mole and the polycationic substance has a weight average molecular weight of about 600,000 to about 1,000,000 grams per mol, and wherein the ratio of the weight average molecular weight of the crosslinked polyamideamine to the weight average molecular weight of the polycationic substance is greater than 1 to about 3. 19. The method of claim 18, wherein the polyamideamine is formed from a polyalkylenepolyamine prepolymer. 20. The method of claim 18, wherein the polyalkylenepolyamine is polyethyleneimine, a polyamine that is grafted with ethyleneimine, or a combination thereof. 21. The method of claim 18, wherein the ratio of the weight average molecular weight of the crosslinked polyamideamine to the weight average molecular weight of the polycationic substance is from about 1.2 to about 1.8. 22. The method of claim 18, wherein the polycationic substance is a polyamine. 23. The method of claim 18, wherein the fibrous substrate contains absorbent fibers. 24. The method of claim 18, wherein about 90% or more of the antimicrobial agent added to the germicidal solution is expressed from the wipe. 25. The method of claim 18, wherein the wipe provides a log reduction of at least about 4 for a gram negative bacteria. 26. The method of claim 25, wherein the gram negative bacteria is E.Coli.
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