The Trustees of Columbia University in the City of New York
대리인 / 주소
Miles & Stockbridge P.C.
인용정보
피인용 횟수 :
3인용 특허 :
194
초록▼
Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments,
Devices, systems and methods are disclosed for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The embodiments may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of small molecules, middle molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
대표청구항▼
1. A method of performing a blood treatment, comprising: withdrawing blood from a live patient and flowing withdrawn blood into a stack of rectangular microfluidic channels each sized and shaped, and at a flow rate, to produce a shear rate such that cellular components of the blood migrate to the ce
1. A method of performing a blood treatment, comprising: withdrawing blood from a live patient and flowing withdrawn blood into a stack of rectangular microfluidic channels each sized and shaped, and at a flow rate, to produce a shear rate such that cellular components of the blood migrate to the center of each microfluidic channel and leave a sheath as cell-free, essentially pure plasma;each microfluidic channel having an aspect ratio perpendicular to the flow direction of at least 10, the minimum dimension being a depth and the maximum dimension being a width;withdrawing the essentially pure plasma from each microfluidic channel through two outlets positioned across the depth;simultaneously withdrawing plasma-depleted blood from each microfluidic channel from the middle of each microfluidic channel between the two outlets;combining withdrawn pure plasma flow from the stack of microfluidic channels and pumping the withdrawn pure plasma at a positive pressure through a membrane filter to ultrafilter water and uremic toxins therefrom to produce dehydrated plasma at an outlet of the filter;returning the dehydrated plasma and the plasma-depleted blood to the patient;performing the above operations continuously over a treatment period of time encompassing a majority of a day, the stack being a component of a wearable system,wherein the rate of water removal over the treatment period of time is sufficient to regulate the water burden of a patient with renal failure. 2. The method of claim 1, wherein the returning the dehydrated plasma to the patient includes pumping the dehydrated plasma into the stack of microfluidic channels. 3. The method of claim 2, wherein the returning the dehydrated plasma to the patient includes shunting the dehydrated plasma directly into the blood stream of the patient. 4. The method of claim 2, wherein the pumping the withdrawn pure plasma at a positive pressure through a membrane filter to ultrafilter water and uremic toxins from the pure plasma includes diafiltering the pure plasma. 5. The method of claim 1, wherein the returning the dehydrated plasma to the patient includes shunting the dehydrated plasma directly into the blood stream of the patient. 6. The method of claim 5, wherein the pumping the withdrawn pure plasma at a positive pressure through a membrane filter to ultrafilter water and uremic toxins from the pure plasma includes diafiltering the pure plasma. 7. The method of claim 1, wherein the pumping the withdrawn pure plasma at a positive pressure through a membrane filter to ultrafilter water and uremic toxins from the pure plasma includes diafiltering the pure plasma. 8. The method of claim 1, further comprising regulating the flow through the microfluidic channels to decrease the flow of blood in response to a detection of a threshold amount of blood cells in the plasma withdrawn from each microfluidic channel through said two outlets. 9. The method of claim 1, wherein the aspect ratio is at least 50. 10. The method of claim 1, wherein the channel depth is less than 100 microns. 11. The method of claim 1, wherein the ultrafiltering of water and uremic toxins from the pure plasma retains all the proteins in the dehydrated plasma.
Okuzumi Yuzi (Belle Mead NJ) Mellon A. Darline (Bridgewater NJ) Wasserman David (Springfield NJ), Addition copolymers of lactide and glycolide and method of preparation.
Wells John R. (Culver City CA) Grant John W. (Blacksburg VA), Apparatus for continuous separation of leukocyte/platelet-enriched fraction from whole blood.
Delcommune Luc (Monfalcone ITX) Ghyselinck Philippe (Braine-L\Alleud BEX), Article made of lactic acid polymer capable of being employed particularly as a biodegradable prosthesis and process for.
Calhoun Jason H. (Galveston TX) Mader Jon T. (Galveston TX), Biodegradable antibiotic implants and methods of their use in treating and preventing infections.
Tuan Rocky S. (Chester Springs PA) Lin Sheldon S. (Philadelphia PA), Biodegradable drug delivery system for the prevention and treatment of osteomyelitis.
Dunn Richard L. (451 Boardwalk Dr. RLD ; Apt. 501 Fort Collins CO 80526) English James P. (2500 Melinda Cir. Birmingham AL 35214) Cowsar Donald R. (4657 Round Forest Dr. Birmingham AL 35213) Vanderbi, Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David D. (Birmingham AL), Biodegradable in-situ forming implants and methods of producing the same.
Dunn Richard L. (Fort Collins CO) English James P. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Vanderbilt David P. (Birmingham AL), Biodegradable in-situ forming implants and methods of producing the same.
Silver Frederick A. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Birk David E. (Somerset NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Somerset NJ), Biodegradable matrix and methods for producing same.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Southard George L. (Fort Collins CO) Rogers Jack A. (Fort Collins CO), Biodegradable system for regenerating the periodontium.
Kaplan, Donald S.; Hermes, Matthew; Muth, Ross R.; Kennedy, John, Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom.
Yao Shang J. (5 Bayard Road - Apt. 920 Pittsburgh PA 15213) Wolfson Sidney K. (205 Buckingham Road Pittsburgh PA 15215), Blood and tissue detoxification apparatus.
Greenwood Roger N. (London GBX) Aldridge Colin (London GBX) Tattershall James E. (London GBX) Barrett Rodney V. (Bristol GBX), Blood purification apparatus.
Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239) Gutmann James L. (10112 Daventry Dr. Cockeysville MD 21030) Heatfield Barry M. (33 Penny La. Baltimore MD 21209), Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Wozney John M. (Hudson MA) Wang Elizabeth A. (Carlisle MA) Rosen Vicki A. (Brookline MA) Celeste Anthony J. (Hudson MA), DNA sequences encoding BMP-6 proteins.
Muchow David C. (Transit Township ; Sibley County MN) Sirvio Larry M. (Cottage Grove MN), Device and method for extended delivery of pharmacologically active agents to the ear.
Weitzel, William Frederick; Humes, H. David; Paganini, Emil Presley; Buffington, Deborah Ann; Funke, Angela J., Extracorporeal fluid circuit and related methods.
Loughnane Michael H. (Lafayette Hill PA) Wiesmann William P. (Bethesda MD) Pearce Frederick J. (Olney MD) Kearney George P. (Durham NC), High effieciency balanced oscillating shuttle pump.
Dunn Richard L. (Fort Collins CO) Tipton Arthur J. (Fort Collins CO) Harkrader Ronald J. (Louisville CO) Rogers Jack A. (Fort Collins CO), Intragingival delivery systems for treatment of periodontal disease.
Rutherford Robert B. (Farmington CT), Issue repair and regeneration through the use of platelet derived growth factor (PDGF) in combination with dexamethasone.
Trml Pertti (Reikonkatu 7 C 7 SF-33730 Tampere FIX) Vainionp Seppo (Orapihlajatie 21-27 B 12 SF-00320 Helsinki FIX) Rokkanen Pentti (Marjaniemenranta 29 SF-00930 Helsinki FIX) Helevirta Pertti (Ojava, Layered surgical biocomposite material.
Tang Reginald T. (Warren NJ) Mares Frank (Whippany NJ) Boyle ; Jr. William J. (Parsippany NJ) Chiu Tin-Ho (Millburn NJ) Patel Kundanbhai M. (Landing NJ), Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lact.
Wahlig Helmut (Darmstadt DEX) Dingeldain Elvira (Dreieich DEX) Braun Dietrich (Darmstadt-Arheilgen DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Peyman Gholam A. (123 Walnut St. New Orleans LA 70118), Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye.
Giddings John C. (Salt Lake City UT), Method and apparatus for hydrodynamic relaxation and sample concentration NIN field-flow fraction using permeable wall e.
Wilk Peter J. (185 West End Ave. New York NY 10023) Gruber Steven J. (19 Dogwood Rd. Albertson NY 11507), Method and device for removing a toxic substance from blood.
March Keith L. (Carmel IN) Hathaway David R. (Indianapolis IN) Wilensky Robert L. (Indianapolis IN), Method for delivery of smooth muscle cell inhibitors.
Hermes Matthew E. (Easton CT) Muth Ross R. (Brookfield CT), Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting ar.
Rutherford Robert B. (Farmington CT) Charette Marc F. (Needham MA), Method for promoting tissue repair and regeneration using PDGF and glucocorticoids.
Tice Thomas R. (Birmingham AL) Dillon Deborah L. (Helena AL) Mason David W. (Birmingham AL) McRae-McFarlane Amanda (Vastra Frolunda SEX) Dahlstrom Annica B. (Askin SEX), Method for stimulating nerve fiber growth.
Stange Jan,DEX ; Mitzner Steffen,DEX ; Ramlow Wolfgang,DEX, Method for the separation of protein-bound substances from a protein-containing liquid by dialysis.
Brizzolara Nancy S. (Congers NY) Lanzilotti Michael G. (Pearl River NY) Lawter James R. (Goshen NY), Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket,.
Yelick, Pamela C.; Bartlett, John D.; Vacanti, Joseph P.; Olsen, Bjorn R.; Stashenko, Phillip, Methods and compositions for culturing a biological tooth.
Tung Ming S. (15233 Falconbridge Ter. Gaithersburg MD 20878), Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds.
Mueth,Daniel M.; Anderson,Amy; Shireman,Jessica, Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components.
Vert Michel (Deville-les-Rouen FRX) Chabot Francois (Rouen FRX) Leray Jean (Sevres FRX) Christel Pascal (Paris FRX), New prosthesis parts, their preparation and their application.
Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA) Warshawsky Abraham (Rehovot MA ILX) Edelman Elazar (Brookline MA), Polymer composite for controlled release or membrane formation.
DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
Kaplan Donald S. (Weston CT) Hermes Matthew E. (Norwalk CT) Muth Ross R. (Brookfield CT) Kennedy John J. (Stratford CT), Process for making a surgical device using two-phase compositions.
Sherman John D. ; Bem David S. ; Lewis Gregory J., Process for removing toxins from bodily fluids using zirconium or titanium microporous compositions.
Kolff Willem J. (Salt Lake City UT) Shettigar Udipi R. (Salt Lake City UT), Process for therapeutic dissociation of immune complexes and removal of antigens.
Kaplan Donald S. (Weston CT) Hermes Matthew E. (Norwalk CT) Muth Ross R. (Brookfield CT) Kennedy John J. (Stratford CT), Process of making an absorbable surgical device.
Weigl Bernhard H. ; Holl Mark R. ; Zebert Diane ; Kenny Margaret ; Wu Caicai, Simultaneous analyte determination and reference balancing in reference T-sensor devices.
Zagoskin, Alexandre M.; Rose, Geordie; Amin, Mohammad H. S.; Franz, Marcel; Hilton, Jeremy P., Superconducting dot/anti-dot flux qubit based on time-reversal symmetry breaking effects.
Jamiolkowski Dennis D. (Long Valley NJ) Gaterud Mark T. (Annandale NJ) Newman ; Jr. Hugh D. (Chester NJ) Shalaby Shalaby W. (Lebanon NJ), Surgical fastener made from glycolide-rich polymer blends.
Smith Carl R. (Bloomingdale NJ) Gaterud Mark T. (Annandale NJ) Jamiolkowski Dennis D. (Long Valley NJ) Newman ; Jr. Hugh D. (Chester NJ) Shalaby Shalaby W. (Lebanon NJ), Surgical fastener made from glycolide-rich polymer blends.
Orsolini Piero (Martigny) Mauvernay Rolland-Yves (Lausanne) Deghenghi Romano (Lausanne CHX), Sustained and controlled release of water insoluble polypeptides.
Leonard, Edward F.; West, Alan C.; Shaplely, Nina C.; Tang, Zhongliang, Systems and methods of blood-based therapies having a microfluidic membraneless exchange device.
Leonard, Edward F.; West, Alan C.; Aucoin, Christian Paul; Nanne, Edgar E., Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams.
Kaplan Donald S. (Weston CT) Hermes Matthew E. (Norwalk CT) Muth Ross R. (Brookfield CT) Kennedy John J. (Stratford CT), Two-phase compositions for absorbable surgical devices.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.