IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0223856
(2007-02-08)
|
등록번호 |
US-8495906
(2013-07-30)
|
우선권정보 |
JP-2006-039529 (2006-02-16) |
국제출원번호 |
PCT/JP2007/052270
(2007-02-08)
|
§371/§102 date |
20100726
(20100726)
|
국제공개번호 |
WO2007/094242
(2007-08-23)
|
발명자
/ 주소 |
- Sugiyama, Koji
- Sezaki, Akira
- Kamada, Takanori
- Hongo, Yoshikiyo
|
출원인 / 주소 |
|
대리인 / 주소 |
Rader, Fishman & Grauer PLLC
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
3 |
초록
▼
The present invention relates to a deaerator 2 including: a liquid flow space; reduced-pressure spaces 25A, 25B, and 25C; gas permeable films 21A, 21B, and 21C that separate these spaces; and a pump for discharging gas from within the reduced-pressure spaces 25A, 25B, and 25C to the outside, and to
The present invention relates to a deaerator 2 including: a liquid flow space; reduced-pressure spaces 25A, 25B, and 25C; gas permeable films 21A, 21B, and 21C that separate these spaces; and a pump for discharging gas from within the reduced-pressure spaces 25A, 25B, and 25C to the outside, and to a liquid chromatograph equipped with the deaerator 2. The deaerator 2 further includes gas partial pressure variation suppression means 23A, 23B, 23C, 25Ab, 25Bb, 25Cb, 29A, 29B, and 29C for suppressing variations in partial pressures of a specific gas in the reduced-pressure spaces 25A, 25B, and 25C.
대표청구항
▼
1. A deaerator comprising: a liquid flow space;a reduced-pressure space;a gas permeable film that separates said spaces; anda pump for discharging a gas from within the reduced-pressure space to the outside,wherein the deaerator further comprises a gas partial pressure variation suppression means fo
1. A deaerator comprising: a liquid flow space;a reduced-pressure space;a gas permeable film that separates said spaces; anda pump for discharging a gas from within the reduced-pressure space to the outside,wherein the deaerator further comprises a gas partial pressure variation suppression means for suppressing variation in partial pressure of a specific gas in the reduced-pressure space, whereinthe gas partial pressure variation suppression means is an oxygen partial pressure variation suppression means for suppressing variation in oxygen partial pressure in the reduced-pressure space,the oxygen partial pressure variation suppression means is configured so as to introduce a gas from the exterior of the deaerator into the reduced-pressure space during deaeration,the oxygen partial pressure variation suppression means has a high pressure drop part for increasing transfer resistance against the gas to be introduced into the reduced-pressure space, andthe high pressure drop part comprises a porous filter. 2. The deaerator according to claim 1, wherein the oxygen partial pressure variation suppression means further has an external air inlet that allows the reduced-pressure space to communicate with the outside of the deaerator, and an external air introduction pipe connected to the external air inlet, and wherein the high pressure drop part is provided at an intermediate portion or end portion of the external air introduction pipe. 3. The deaerator according to claim 2, wherein the oxygen partial pressure variation suppression means has an oxygen partial pressure detection part for monitoring oxygen partial pressure of the reduced-pressure space, and a valve provided at an intermediate portion of the external air introduction pipe, and wherein the oxygen partial pressure variation suppression means is configured so as to control an open and closed state of the valve based on a result of monitoring by the oxygen partial pressure detection part. 4. The deaerator according to claim 1, further comprising: an exhaust outlet that allows the reduced-pressure space to communicate with the outside of the deaerator; andan exhaust pipe for discharging the gas in inside the reduced-pressure space via the exhaust outlet, a portion of the exhaust pipe extending between the exhaust outlet and the pump having high gas permeability,wherein the oxygen partial pressure variation suppression means comprises the portion of the exhaust pipe having high gas permeability. 5. The deaerator according to claim 4, wherein the exhaust pipe is formed from the same material as that of the gas permeable film. 6. The deaerator according to claim 4, further comprising a branch pipe that is provided so as to branch from the exhaust pipe, wherein the branch pipe has high gas permeability and is closed at an intermediate portion thereof or at an end portion thereof. 7. The deaerator according to claim 4, wherein the oxygen partial pressure variation suppression means comprises a valve provided at an intermediate portion of the exhaust pipe, and the oxygen partial pressure variation suppression means is configured so as to set the valve in an open state during deaeration but to close the valve after completion of deaeration. 8. The deaerator according to claim 1, further comprising: an exhaust outlet that allows the reduced-pressure space to communicate with the outside of the deaerator;an exhaust sub-chamber for holding a gas drawn from the reduced-pressure space; andan exhaust pipe for connecting the exhaust outlet and the exhaust sub-chamber,wherein the oxygen partial pressure variation suppression means is configured so as to return the gas in the exhaust sub-chamber to the reduced-pressure space after completion of deaeration. 9. The deaerator according to claim 8, wherein the oxygen partial pressure variation suppression means has a return pipe for returning the gas in the exhaust sub-chamber to the reduced-pressure space, and a valve provided at an intermediate portion of the return pipe, and wherein the oxygen partial pressure variation suppression means is configured so as to set the valve in a closed state during deaeration, and so as to open the valve after completion of deaeration, thereby returning the gas in the exhaust sub-chamber to the reduced-pressure space. 10. The deaerator according to claim 1, wherein the oxygen partial pressure variation suppression means is configured so as to open the reduced-pressure space to the atmosphere when the pump is not driven, and so as to open the reduced-pressure space to the atmosphere during driving of the pump only in a case in which a fixed condition has been satisfied. 11. The deaerator according to claim 10, wherein the oxygen partial pressure variation suppression means is configured so as to open the reduced-pressure space to the atmosphere at fixed intervals or when a partial pressure of an oxygen gas in the reduced-pressure space becomes equal to or greater than a fixed value. 12. The deaerator according to claim 1, wherein the oxygen partial pressure variation suppression means is configured so as to increase a degree of pressure reduction of the reduced-pressure space when a partial pressure of an oxygen gas in the reduced-pressure space becomes equal to or greater than a fixed value. 13. A liquid chromatograph comprising: a column that holds a packing material;one or a plurality of eluent holding parts each holding an eluent to be supplied to the column; anda deaerator for deaerating the eluent during supply of the eluent from an eluent holding part to the column;wherein the deaerator includes:a liquid flow space;a reduced-pressure space;a gas permeable film that separates said spaces;a pump for discharging a gas from within the reduced-pressure space to the outside; anda gas partial pressure variation suppression means for suppressing variation in partial pressure of a specific gas in the reduced-pressure space,wherein the gas partial pressure variation suppression means is an oxygen partial pressure variation suppression means for suppressing variation in oxygen partial pressure in the reduced-pressure space,wherein the oxygen partial pressure variation suppression means is configured so as to introduce a gas from the exterior of the deaerator into the reduced-pressure space during deaeration,wherein the oxygen partial pressure variation suppression means has a high pressure drop part for increasing transfer resistance against the gas to be introduced into the reduced-pressure space, andwherein the high pressure drop part comprises a porous filter. 14. The liquid chromatograph according to claim 13, wherein the oxygen partial pressure variation suppression means further has an external air inlet that allows the reduced-pressure space to communicate with the outside of the deaerator, and an external air introduction pipe connected to the external air inlet, and wherein the high pressure drop part is provided at an intermediate portion or end portion of the external air introduction pipe. 15. The liquid chromatograph according to claim 14, wherein the oxygen partial pressure variation suppression means has an oxygen partial pressure detection part for monitoring oxygen partial pressure of the reduced-pressure space, and a valve provided at an intermediate portion of the external air introduction pipe, and wherein the oxygen partial pressure variation suppression means is configured so as to control an open and closed state of the valve based on a result of monitoring by the oxygen partial pressure detection part. 16. The liquid chromatograph according to claim 13, further comprising: an exhaust outlet that allows the reduced-pressure space to communicate with the outside of the deaerator; andan exhaust pipe for discharging the gas inside the reduced-pressure space via the exhaust outlet, a portion of the exhaust pipe extending between the exhaust outlet and the pump having high gas permeability,wherein the oxygen partial pressure variation suppression means comprises the portion of the exhaust pipe having high gas permeability. 17. The liquid chromatograph according to claim 16, wherein the exhaust pipe is formed from the same material as that of the gas permeable film. 18. The liquid chromatograph according to claim 17, further comprising a branch pipe that is provided so as to branch from the exhaust pipe, wherein the branch pipe has high gas permeability and is closed at an intermediate portion thereof or at an end portion thereof. 19. The liquid chromatograph according to claim 17, wherein the oxygen partial pressure variation suppression means comprises a valve provided at an intermediate portion of the exhaust pipe, and the oxygen partial pressure variation suppression means is configured so as to set the valve in the open state during deaeration but to close the valve after completion of deaeration. 20. The liquid chromatograph according to claim 13, further comprising: an exhaust outlet that allows the reduced-pressure space to communicate with the outside of the deaerator;an exhaust sub-chamber for holding a gas drawn from the reduced-pressure space; andan exhaust pipe for connecting the exhaust outlet and the exhaust sub-chamber,wherein the oxygen partial pressure variation suppression means is configured so as to return the gas in the exhaust sub-chamber to the reduced-pressure space after completion of deaeration. 21. The liquid chromatograph according to claim 20, wherein the oxygen partial pressure variation suppression means has a return pipe for returning the gas in the exhaust sub-chamber to the reduced-pressure space, and a valve provided at an intermediate portion of the return pipe, and wherein the oxygen partial pressure variation suppression means is configured so as to set the valve in a closed state during deaeration, and so as to open the valve after completion of deaeration, thereby returning the gas in the exhaust sub-chamber to the reduced-pressure space. 22. The liquid chromatograph according to claim 13, wherein the oxygen partial pressure variation suppression means is configured so as to open the reduced-pressure space to the atmosphere when the pump is not driven, and so as to open the reduced-pressure space to the atmosphere during driving of the pump only in a case in which a fixed condition has been satisfied. 23. The liquid chromatograph according to claim 21, wherein the oxygen partial pressure variation suppression means is configured so as to open the reduced-pressure space to the atmosphere at fixed intervals or when the partial pressure of an oxygen gas in the reduced-pressure space becomes equal to or greater than a fixed value. 24. The liquid chromatograph according to claim 23, wherein the oxygen partial pressure variation suppression means is configured so as to increase a degree of pressure reduction of the reduced-pressure space when the partial pressure of an oxygen gas in the reduced-pressure space becomes equal to or greater than a predetermined value. 25. The liquid chromatograph according to claim 13, wherein the liquid chromatograph is configured so as to measure glycohemoglobin in a blood sample.
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