IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0845414
(2010-07-28)
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등록번호 |
US-8496911
(2013-07-30)
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발명자
/ 주소 |
- Weldon, Norman R.
- Ogle, Matthew F.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
1 인용 특허 :
28 |
초록
▼
Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardi
Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir. Controlled placement and release of the therapeutic composition can be achieved using a delivery vehicle to formulate the composition.
대표청구항
▼
1. A method for the stabilization of heart tissue in a living subject, the method comprising applying a therapeutic composition to the pericardium of the living subject, to the outer surface of the myocardium of the living subject, or a combination thereof,wherein the therapeutic composition compris
1. A method for the stabilization of heart tissue in a living subject, the method comprising applying a therapeutic composition to the pericardium of the living subject, to the outer surface of the myocardium of the living subject, or a combination thereof,wherein the therapeutic composition comprises an elastin stabilization agent, a collagen stabilization agent, or a combination thereof, wherein the elastin stabilization agent comprises a compound that comprises at least one phenolic hydroxyl group bound to a hydrophobic core and wherein the collagen stabilization agent comprises a photo-activated crosslinking agent, or an aldehyde with at least two aldehyde groups, a polyamine with carbodiimide, a photo-catalytic dye, genipin, an epoxide, an azide ester, or a combination thereof. 2. The method of claim 1 wherein the therapeutic composition further comprises a delivery vehicle. 3. The method of claim 2 wherein the delivery vehicle comprises precursor of hydrogel, polymer nanoparticles with the therapeutic composition embedded therein, or a combination thereof. 4. The method of claim 3 wherein the precursor of hydrogel comprises poloxamer block copolymers. 5. The method of claim 3 wherein the nanoparticles comprises poly(lactic acid-co-glycolic) acid. 6. The method of claim 1 wherein the elastin stabilization agent and the collagen stabilization agent are applied simultaneously or sequentially. 7. The method of claim 1 wherein the therapeutic composition is applied through the access of the heart using a catheter structure. 8. The method of claim 1 wherein the therapeutic composition is applied through the access of the heart using an access port or alike. 9. The method of claim 1 wherein the therapeutic composition is applied to the heart tissue using a cardiac reinforcement wrap or a patch. 10. The method of claim 1 further comprising an aspiration step before the application of the therapeutic composition. 11. The method of claim 1 wherein the application of the therapeutic composition is repeated with the same or a different therapeutic composition. 12. The method of claim 1 wherein the elastin stabilization agent comprises a compound that is tannic acid or a derivative thereof, a flavonoid or a flavonoid derivative, a flavolignan or a flavolignan derivative, a phenolic rhizome or a phenolic rhizome derivative, a flavan-3-ol or a flavan-3-ol derivative, an ellagic acid or an ellagic acid derivative, a procyanidin or a procyanidin derivative, anthocyanins, quercetin, (+)-catechin, (−)-epicatechin, pentagalloylglucose, nobotanin, epigallocatechin gallate, gallotannins, an extract of olive oil or a derivative of an extract of olive oil, cocoa bean or a derivative of a cocoa bean, Camellia or a derivative of camellia, licorice or a derivative of licorice, sea whip or a derivative of sea whip, aloe vera or a derivative of aloe vera, chamomile or a derivative of chamomile, a combination thereof, or a pharmaceutically acceptable salt thereof. 13. The method of claim 1 wherein the elastin stabilization agent comprises pentagalloylglucose, an analog of pentagalloylgiucose, a pharmaceutically acceptable salt thereof, or a combination thereof. 14. The method of claim 1 wherein the collagen stabilization agent comprises an aldehyde with at least two aldehyde groups, a polyamine with carbodiimide, a photo-catalytic dye, genipin, an epoxide, an azide ester, or a combination thereof. 15. The method of claim 1 wherein the collagen stabilization agent comprises glutaraldehyde. 16. The method of claim 1 wherein the collagen stabilization agent comprises a photo-activated crosslinking agent.
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