An article comprising two chemically grafted polymer layers comprising a hydrogel layer and an end-functionalized polyurethane layer. The invention also includes methods of making and using the article.
대표청구항▼
1. An article comprising two chemically grafted polymer layers comprising a hydrogel layer and an end-functionalized polyurethane layer, wherein the hydrogel layer is covalently linked to the end-functionalized polyurethane layer at an interface between the two layers. 2. The article of claim 1 wher
1. An article comprising two chemically grafted polymer layers comprising a hydrogel layer and an end-functionalized polyurethane layer, wherein the hydrogel layer is covalently linked to the end-functionalized polyurethane layer at an interface between the two layers. 2. The article of claim 1 wherein the polyurethane comprises polycarbonate urethane, polycarbonate urethane urea, polyester urethane, polyether urethane, polyurethane urea, or a silicone derivative of these. 3. The article of claim 1 wherein the polyurethane comprises hard and soft segments, chain extenders and endgroups. 4. The article of claim 3 wherein the polyurethane hard segments comprise 1,5 naphthalene diisocyanate (NDI), isophorone isocyanate (IPDI), 3,3-bitoluene diisocyanate (TODI), methylene bis(p-cyclohexyl isocyanate) (H12MDI), cyclohexyl diiscocyanate (CHDI), 2,6 tolulene diisocyanate or 2,4 toluene diisocyanate (TDI), hexamethyl diisocyanate (HMDI), or methylene bis(p-phenyl isocyanate) (MDI). 5. The article of claim 3 wherein the polyurethane soft segments comprise hydroxy terminated butadiene, hydroxyl terminated polyisobutylene, hydroxybutyl terminated polydimethylsiloxane (PDMS), poly(1,6 hexyl 1,2-ethyl carbonate), hydrogenated polybutadiene, polycaprolactone, polyethylene adipate, polyethylene oxide (PEO), polyhexamethylene carbonate glycol, polypropylene oxide (PPO), polytetramethylene adipate, or poly(tetramethylene oxide) (PTMO). 6. The article of claim 3 wherein the polyurethane chain extenders comprise 1,4 butanediol, ethylene diamine, 4,4′ methylene bis(2-chloroaniline) (MOCA), ethylene glycol, or hexane diol. 7. The article of claim 3 wherein the polyurethane endgroups comprise acylamide, acrylate, allyl ether, methacrylate, or vinyl. 8. The article of claim 1 wherein the hydrogel comprises end-linked macromeric subunits. 9. The article of claim 8 wherein the macromeric subunits are PEG. 10. The article of claim 1 wherein the hydrogel comprises a biomolecule. 11. The article of claim 10 wherein the biomolecule comprises collagen, one or more growth factors, steroids, bisphosphonates, or combinations or derivatives thereof. 12. The article of claim 11 wherein the growth factors comprise one or more of a Bone Morphogenetic Protein, a Fibroblast Growth Factor, a Transforming Growth Factor, or a Osteogenic Protein. 13. The article of claim 1 wherein the hydrogel comprises a homopolymer. 14. The article of claim 1 wherein the hydrogel comprises polymerized monomeric subunits. 15. The article of claim 1 wherein the hydrogel comprises a copolymer. 16. The article of claim 15 wherein the copolymer comprises polymerized subunits. 17. The article of claim 16 wherein the subunits are one or more of acrylamide, hydroxyethyl acrylamide, N-isopropyl acrylamide, 2-hydroxyethyl methacrylate, and 2-hydroxyethyl acrylate. 18. The article of claim 15 wherein at least 50% of the dry weight of hydrogel comprises telechelic macromonomer. 19. The article of claim 15 wherein at least 75% of the dry weight of hydrogel comprises telechelic macromonomer. 20. The article of claim 15 wherein at least 95% of the dry weight of hydrogel comprises telechelic macromonomer. 21. The article of claim 1 wherein the hydrogel comprises an IPN comprising a first and a second network. 22. The article of claim 21 wherein the first network comprises polymerized macromeric subunits. 23. The article of claim 22 wherein the macromeric subunit comprises PEG, poly(N-vinyl pyrrolidone), polydimethylsiloxane, poly(vinyl alcohol), polysaccharide, or a biomolecule. 24. The article of claim 22 wherein the macromeric subunit comprises end group or side group functionalities, said end group or side group functionalities comprising at least one of acrylamide, acrylate, allyl, methacrylamide, methacrylate, N-vinyl sulfone, and vinyl. 25. The article of claim 21 wherein the second network comprises polymerized subunits. 26. The article of claim 25 wherein the second network is hydrophilic. 27. The article of claim 26 wherein the second network is ionizable. 28. The article of claim 27 wherein the ionizable network is anionic. 29. The article of claim 28 wherein the subunits of the anionic second network comprise at least one of carboxylic acid and sulfonic acid groups. 30. The article of claim 28 wherein the anionic second network is polyacrylic acid. 31. The article of claim 28 wherein the ionizable network is cationic. 32. The article of claim 26 wherein the hydrophilic network is non-ionic. 33. The article of claim 32 wherein the subunits of the non-ionic network comprise one or more of acrylamide, methacrylamide, N-hydroxyethyl acrylamide, N-isopropylacrylamide, methymethacrylate, N-vinyl pyrrolidone, 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, or derivatives of these. 34. The article of claim 21 wherein both networks are grafted to the polyurethane. 35. The article of claim 1 further comprising a second polyurethane attached to the first polyurethane. 36. The article of claim 35 wherein the second polyurethane comprises functionalized end groups. 37. The article of claim 35 wherein the second polyurethane comprises salt. 38. The article of claim 35 wherein the second polyurethane is porous. 39. The article of claim 35 wherein the second polyurethane comprises a foaming agent. 40. The article of claim 35 wherein the second polyurethane further comprises a biomolecule. 41. The article of claim 40 wherein the biomolecule comprises at least one of collagen, bone morphogenetic protein, bisphosphonate, and an osteogenic protein. 42. The article of claim 35 wherein the second polyurethane further comprises a bone component. 43. The article of claim 42 wherein the bone component is one of at least carbonated apatite, hydroxyapatite, alpha tricalcium phosphate, beta tricalcium phosphate, and other calcium phosphates. 44. The article of claim 1 further comprising entrapped fillers. 45. The article of claim 1 further comprising an antioxidant. 46. The article of claim 45 wherein the antioxidant is selected from the group consisting of ascorbic acid, Vitamin E, Irganox®, santowhite, glutathione, uric acid, lipoic acid, beta carotene, retinol, and ubiquinol.
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