Stimuli-responsive magnetic nanoparticles and related methods
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-033/20
출원번호
US-0161233
(2011-06-15)
등록번호
US-8507283
(2013-08-13)
발명자
/ 주소
Stayton, Patrick S.
Hoffman, Allan S.
Lai, Jr-iuan
Hoffman, John
Ebara, Mitsuhiro
출원인 / 주소
University of Washington
대리인 / 주소
Christensen O'Connor Johnson Kindness PLLC
인용정보
피인용 횟수 :
7인용 특허 :
46
초록
Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.
대표청구항▼
1. A stimuli-responsive magnetic nanoparticle responsive to a magnetic field, comprising: (a) a solid metal oxide core responsive to a magnetic field; and(b) a plurality of stimuli-responsive polymer molecules each having a proximal end comprising a micelle-forming moiety and a distal end comprising
1. A stimuli-responsive magnetic nanoparticle responsive to a magnetic field, comprising: (a) a solid metal oxide core responsive to a magnetic field; and(b) a plurality of stimuli-responsive polymer molecules each having a proximal end comprising a micelle-forming moiety and a distal end comprising a stimuli-responsive moiety, wherein the micelle-forming moiety of each of the plurality of stimuli-responsive polymer molecules becomes incorporated within the solid metal oxide core by: (i) providing a first solution of the plurality of stimuli-responsive polymer molecules in a solvent that is a poor solvent for the micelle-forming moiety;(ii) forming a micelle in the first solution, wherein the micelle dimensions are spatially defined by the micelle-forming moieties;(iii) providing a second solution of a metal compound that is a precursor to the metal oxide core;(iv) introducing the second solution into the micelle, wherein the second solution is more soluble in the micelle than in the first solution, causing the second solution to preferentially concentrate in the micelle; and(v) solidifying the precursor within the micelle in order to incorporate the micelle-forming moiety of each of the plurality of stimuli-responsive polymer molecules within a solid metal oxide core;wherein the stimuli-responsive moiety is self-associative in response to a stimulus. 2. The nanoparticle of claim 1, wherein the metal oxide is selected from the group consisting of ferrous oxide, ferric oxide, gadolinium oxide, and mixtures thereof. 3. The nanoparticle of claim 1, wherein the stimuli-responsive polymer molecules respond to a stimulus selected from the group consisting of temperature, pH, light, electric field, and ionic strength. 4. The nanoparticle of claim 1, wherein the stimuli-responsive polymer molecules comprise a polymer having a balance of hydrophilic and hydrophobic groups. 5. The nanoparticle of claim 1, wherein the stimuli-responsive polymer molecules are temperature-responsive. 6. The nanoparticle of claim 1, wherein the stimuli-responsive polymer molecules comprise polymers or copolymers of N-isopropylacrylamide. 7. The nanoparticle of claim 1, wherein the stimuli-responsive polymer molecules are multi-responsive copolymer molecules. 8. The nanoparticle of claim 1, wherein the solid metal oxide core has a diameter of from about 2 nm to about 20 nm. 9. The nanoparticle of claim 1, wherein the micelle-forming moiety comprises a micelle-forming hydrophobic moiety. 10. The nanoparticle of claim 9, wherein the micelle-forming hydrophobic moiety comprises alkyl, polyester, polyamide, or polypeptide moieties. 11. The nanoparticle of claim 9, wherein the micelle-forming hydrophobic moiety comprises a n-dodecyl group. 12. The nanoparticle of claim 1, wherein the nanoparticle has a diameter from about 5 nm to about 30 nm. 13. A method of forming a stimuli-responsive magnetic nanoparticle responsive to a magnetic field, the method comprising: providing a first solution of a plurality of stimuli-responsive polymer molecules, each having a proximal end comprising a micelle-forming moiety and a distal end comprising a stimuli-responsive moiety, wherein the stimuli-responsive moiety is self-associative in response to a stimulus, and wherein the first solution comprises a solvent that is a poor solvent for the micelle-forming moiety;forming a micelle in the first solution, wherein the micelle dimensions are spatially defined by the micelle-forming moieties;providing a second solution of a metal compound that is a precursor to a solid metal oxide;introducing the second solution into the micelle, wherein the second solution is more soluble in the micelle than in the first solution, causing the second solution to preferentially concentrate in the micelle; andsolidifying the precursor within the micelle in order to incorporate the micelle-forming moiety of each of the plurality of stimuli-responsive polymer molecules within a solid metal oxide core. 14. The method of claim 13, wherein the metal oxide is selected from the group consisting of ferrous oxide, ferric oxide, gadolinium oxide, and mixtures thereof. 15. The method of claim 13, wherein the stimuli-responsive polymer molecules respond to a stimulus selected from the group consisting of temperature, pH, light, electric field, and ionic strength. 16. The method of claim 13, wherein the stimuli-responsive polymer molecules comprise polymers or copolymers of N-isopropylacrylamide. 17. The method of claim 13, wherein the stimuli-responsive polymer molecules are multi-responsive copolymer molecules. 18. The method of claim 13, wherein the solid metal oxide core has a diameter of from about 2 nm to about 20 nm. 19. The method of claim 13, wherein the micelle-forming moiety comprises a micelle-forming hydrophobic moiety. 20. The method of claim 13, wherein the nanoparticle has a diameter from about 5 nm to about 30 nm.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (46)
Takahashi, Yuki; Ohnishi, Noriyuki; Xie, Xiaomao, Aggregation and dispersion methods of magnetic particles, separation and detection methods using the same and detection kit.
Eguchi, Masaru; Ohnishi, Noriyuki, Aqueous solution of polymer having upper critical solution temperature, aqueous dispersion of particle modified with the polymer and method of storing the same.
Curiel David T. (Chapel Hill NC) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX) Zatloukal Kurt (Vienna ATX) Plank Christian (Vienna ATX) Oberhauser Berndt, Composition for introducing nucleic acid complexes into higher eucaryotic cells.
Curiel David T. (Chapel Hill NC) Hu Ping-chuan (Chapel Hill NC) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX), Conjugates for introducing nucleic acid into higher eucaryotic cells.
Chien Yie W. (North Brunswick NJ) Chen Li-Lan H. (Edison NJ), Disposable dosage unit for iontophoresis-facilitated transdermal delivery, related devices and processes.
Hoffman, Allan S.; Stayton, Patrick; Press, Oliver W.; Tirrell, David; Murthy, Niren; Lackey, Chantal; Crum, Lawrence A.; Mourad, Pierre D.; Porter, Tyrone M., Enhanced transport using membrane disruptive agents.
Charmot Dominique (Paris FRX) Vidil Christine (Paris FRX), Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application.
Ernst Bayer DE; Hans Fritz DE; Martin Maier ; Jens Schewitz DE; Michael Gerster DE, Method for isolating anionic organic substances from aqueous systems using cationic polymer nanoparticles.
Elaissari,Abdelhamid; Mandrand,Bernard; Delair,Thierry; Spencer,Doran; Arkis,Ahmed, Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses.
Feng Xiangdong ; Liu Jun ; Liang Liang, Method of bonding functional surface materials to substrates and applications in microtechnology and antifouling.
Gombotz Wayne R. (Kirkland WA) Mumper Russell J. (Greenville NC) Hoffman Allan S. (Seattle WA) Bouchard Lisa S. (Renton WA), Methods and compositions for the oral delivery of therapeutic agents.
Hooper Herbert H. (Belmont CA) Pacetti Stephen (Sunnyvale CA) Soane David S. (Piedmont CA) Bae Young C. (Seoul KRX), Separation media for electrophoresis.
Yoshizako, Kimihiro; Akiyama, Yoshikatsu; Ueno, Katsuhiko; Okano, Teruo, Separatory material with the use of stimulus-responsive polymer and separation method by using the separatory material.
Monji Nobuo (Seattle WA) Hoffman Allan S. (Seattle WA) Priest John H. (Everett WA) Houghton Raymond L. (Kirkland WA), Thermally induced phase separation immunoassay.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.