Methods of tissue repair and compositions therefor
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61F-002/00
출원번호
US-0448701
(2006-06-07)
등록번호
US-8512730
(2013-08-20)
발명자
/ 주소
Seyedin, Mitchell S.
Gage, Gary
출원인 / 주소
Isto Technologies, Inc.
대리인 / 주소
Polsinelli PC
인용정보
피인용 횟수 :
3인용 특허 :
28
초록▼
The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also d
The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor or an anti-infective agent. In some configurations, a matrix can be a viscous fluid or a paste, while in other configurations a matrix can be comprised by a solid such as a plug, a granule or a membrane.
대표청구항▼
1. A method of promoting tissue growth at a tissue site in need of tissue growth in a mammal in need thereof, the method comprising injecting an injectable tissue matrix composition at the site, wherein the injectable matrix composition comprises polyester polymers entangled with hyaluronic acid pol
1. A method of promoting tissue growth at a tissue site in need of tissue growth in a mammal in need thereof, the method comprising injecting an injectable tissue matrix composition at the site, wherein the injectable matrix composition comprises polyester polymers entangled with hyaluronic acid polymers by a process comprising the steps of: (i) dissolving the polyester polymers in an organic solvent; (ii) blending the polyester polymers with hyaluronic acid polymers contained in an aqueous medium to form an emulsified mixture; and (iii) pouring the emulsified mixture of the two polymers into a mold, (iv) successively removing the organic solvent and water from the mold to form a solid matrix comprising the polyester polymers entangled with the hyaluronic acid polymers; (v) granulating the solid matrix to form matrix granules; and (vi) combining the matrix granules with an aqueous liquid solution comprising hyaluronic acid to form a paste or a viscous liquid capable of injection at the tissue site. 2. The method of claim 1, wherein the matrix composition comprises a paste. 3. The method of claim 1, wherein the matrix composition comprises a viscous liquid. 4. The method of claim 1, wherein the mammal is a human in need of treatment. 5. The method of claim 1, wherein the site in need of tissue growth comprises bone and periosteal tissue. 6. The method of claim 1, wherein the tissue growth comprises facial contour augmentation. 7. The method of claim 1, wherein the matrix further comprises at least one therapeutic agent. 8. The method of claim 7, wherein the at least one therapeutic agent is selected from the group consisting of an anti-infective agent, a pain medication, an analgesic, an anti-inflammatory agent, and an immunosuppressive agent. 9. The method of claim 1, wherein the site in need of tissue growth comprises bone and a periodontal ligament. 10. The method of claim 1, wherein the site in need of tissue growth comprises bone and cartilage. 11. The method of claim 1, wherein the site in need of tissue growth comprises bone and hyaline cartilage. 12. The method of claim 11 wherein the hyaline cartilage is costal cartilage. 13. The method of claim 1, wherein the site in need of tissue growth comprises bone and fibrous cartilage. 14. The method of claim 13 wherein the fibrous cartilage is meniscus cartilage. 15. The method of claim 1, wherein the polyester polymers and hyaluronic acid polymers are combined at a weight ratio of polyester polymers to hyaluronic polymers of between 9:1 and 1:9. 16. The method of claim 1, wherein the matrix composition is characterized by (i) retention of pore structure and shape when hydrated, and (ii) the ability to support the growth of cells in vivo or ex vivo. 17. The method of claim 1, wherein the site in need of tissue growth is selected from the group consisting of bone tissue, cartilage tissue, tendon tissue, ligament tissue, vascular tissue, dermal tissue, periodontal tissue, intervertebral disc tissue, hyaline cartilage, fibrous cartilage, elastic cartilage, a nerve tunnel or a combination thereof.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (28)
Vacanti Joseph P. ; Vacanti Charles A. ; Langer Robert S., Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous struct.
Abatangelo, Giovanni; Callegaro, Lanfranco, Biological material containing bone marrow stem cells partially or completely differentiated into connective tissue cells and a hyaluronic acid ester matrix.
Ron Eyal (Lexington MA) Turek Thomas J. (Boston MA) Isaacs Benjamin S. (Tewksbury MA) Patel Himakshi (Tewksbury MA) Kenley Richard A. (Andover MA), Pharmaceutical formulations of osteogenic proteins.
Liu,LinShu; Fishman,Marshall L.; Hicks,Kevin B., Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.