IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0488862
(2009-06-22)
|
등록번호 |
US-8518432
(2013-08-27)
|
우선권정보 |
JP-2004-301796 (2004-10-15) |
발명자
/ 주소 |
- Yamamoto, Katsushi
- Yamanaka, Katsuyuki
- Suda, Youko
- Kaneko, Tadashi
|
출원인 / 주소 |
|
대리인 / 주소 |
Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
2 |
초록
▼
A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organ
A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 μm diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 μm diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.
대표청구항
▼
1. A production method for a block-shaped scaffold for tissue engineering, the method comprising, approximate-uniformly mixing a particle-shaped material having a particle diameter of 100 to 2000 μm with a solution in which a bioabsorbable polymer is dissolved with an organic solvent, where the part
1. A production method for a block-shaped scaffold for tissue engineering, the method comprising, approximate-uniformly mixing a particle-shaped material having a particle diameter of 100 to 2000 μm with a solution in which a bioabsorbable polymer is dissolved with an organic solvent, where the particle-shaped material is not dissolved with said organic solvent but dissolved in a liquid in which the bioabsorbable polymer is not dissolved, freezing the mixture, drying it to remove said organic solvent, and producing thereby a polymer material containing the particle-shaped material and having a small hole structure wherein a hole diameter is 5 to 50 μm; pulverizing said produced polymer material, removing said particle-shaped material by dissolving with a liquid in which the bioabsorbable polymer is not dissolved, passing through a sieve, and producing thereby a bioabsorbable granular porous material having a particle diameter of 100 to 3000 μm; and taking said bioabsorbable granular porous material into a mold, pressing and heating the bioabsorbable granular porous material, producing thereby the block-shaped scaffold for tissue engineering having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having the small hole structure with the hole diameter of 5 to 50 μm, having an elastic coefficient of 0.1 to 2.5 MPa, and a volume change of 95 to 105% when dipping in water for 24 hours. 2. The production method of claim 1, wherein the bioabsorbable polymer material is at least one member selected from the group consisting of polyglycolic acid, polylactic acid, a copolymer of lactic acid and glycolic acid, poly-ε-caprolactone, a copolymer of lactic acid and ε-caprolactone, polyamino acid, polyortho ester, and copolymers thereof. 3. The production method of claim 1, wherein the organic solvent is at least one member selected from the group consisting of chloroform, dichloromethane, carbon tetrachloride, acetone, dioxane, and tetrahydrofuran. 4. The production method of claim 1, wherein the block-shaped scaffold for the tissue engineering is produced by heating the bioabsorbable granular porous material at 60 to 200° C. while keeping the volume in a state of being pressed at 500 to 3000 g/cm2. 5. The production method of claim 2, wherein the organic solvent is at least one member selected from the group consisting of chloroform, dichloromethane, carbon tetrachloride, acetone, dioxane, and tetrahydrofuran. 6. The production method of claim 2, wherein the block-shaped scaffold for the tissue engineering is produced by heating the bioabsorbable granular porous material at 60 to 200° C. while keeping the volume in a state of being pressed at 500 to 3000 g/cm2. 7. The production method of claim 3, wherein the block-shaped scaffold for the tissue engineering is produced by heating the bioabsorbable granular porous material at 60 to 200° C. while keeping the volume in a state of being pressed at 500 to 3000 g/cm2. 8. The production method of claim 5, wherein the block-shaped scaffold for the tissue engineering is produced by heating the bioabsorbable granular porous material at 60 to 200° C. while keeping the volume in a state of being pressed at 500 to 3000 g/cm2.
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