Biodegradable osmotic pump implant for drug delivery
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/52
A61K-009/24
A61K-031/19
출원번호
US-0974394
(2010-12-21)
등록번호
US-8518440
(2013-08-27)
발명자
/ 주소
Blaskovich, Phillip
Ohri, Rachit
Bennett, Steven
출원인 / 주소
Confluent Surgical, Inc.
인용정보
피인용 횟수 :
5인용 특허 :
42
초록▼
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
대표청구항▼
1. An implantable drug delivery device comprising: a biodegradable pouch comprising a biodegradable polymeric material comprising a first precursor comprising electrophilic groups and a second precursor comprising nucleophilic groups; anda biodegradable hydrogel formed of a first hydrogel precursor
1. An implantable drug delivery device comprising: a biodegradable pouch comprising a biodegradable polymeric material comprising a first precursor comprising electrophilic groups and a second precursor comprising nucleophilic groups; anda biodegradable hydrogel formed of a first hydrogel precursor comprising electrophilic groups and a second hydrogel precursor comprising nucleophilic groups within said biodegradable pouch;wherein the biodegradable polymeric material, the biodegradable hydrogel, or both, comprises a bioactive agent. 2. The implantable drug delivery device of claim 1, wherein the electrophilic groups of the first hydrogel precursor comprise N-hydroxysuccinimides and the nucleophilic groups of the second hydrogel precursor comprise amines. 3. The implantable drug delivery device of claim 1, wherein the biodegradable polymeric material comprises a second hydrogel capable of a changing in size by a weight decrease of from about 1% to about 50% or a weight increase from about 0% to about 50%, and the biodegradable hydrogel swells by an amount of from about 40% by weight to about 600% by weight. 4. The implantable drug delivery device of claim 1, wherein the first precursor comprises a multi-armed precursor possessing a core and arms, the arms each comprising a polyethylene glycol having a molecular weight from about 250 to about 5000. 5. The drug delivery device of claim 4, wherein the core is selected from the group consisting of polyethers, polyamino acids, proteins, and polysaccharides. 6. The implantable drug delivery device of claim 4, wherein the core is selected from the group consisting of polyethylene glycol, polyethylene oxide, polyethylene oxide-co-polypropylene oxide, co-polyethylene oxide copolymers, polyvinyl alcohol, polyvinyl pyrrolidinone, dextran, chitosan, carboxymethylcellulose, oxidized cellulose, derivatives thereof, and combinations thereof. 7. The implantable drug delivery device of claim 1, wherein the nucleophilic groups comprise amines. 8. The implantable drug delivery device of claim 1, wherein the biodegradable polymeric material comprises a low-swelling hydrogel capable of a changing in size by a weight decrease of from about 5% to about 30% or a weight increase from about 10% to about 40%, and the biodegradable hydrogel swells by an amount of from about 100% by weight to about 400% by weight. 9. The implantable drug delivery of claim 1, wherein the biodegradable polymeric material is selected from the group consisting of oxidized cellulose, polylactide, polyglycolide, polylactide-co-glycolide copolymer, and combinations thereof. 10. The implantable drug delivery device of claim 1, wherein the biodegradable pouch further comprises an inner layer and at least one outer layer. 11. The implantable drug delivery device of claim 10, wherein the at least one outer layer is selected from the group consisting of oxidized cellulose, polylactide, polyglycolide, polylactide-co-glycolide copolymer, and combinations thereof. 12. The implantable drug delivery device of claim 10, wherein the at least one outer layer comprises a molecular weight cut off membrane. 13. The implantable drug delivery device of claim 1, wherein the bioactive agent is selected from the group consisting of local anesthetics, vitamins, hormones, and combinations thereof. 14. The implantable drug delivery device of claim 1, wherein the biodegradable pouch is semi-permeable. 15. The implantable drug delivery device of claim 1, wherein the bioactive agent is encapsulated in a polymeric microcapsule. 16. The implantable drug delivery device of claim 1, wherein the implantable drug delivery device possesses a shape selected from the group consisting of circular, discs, rods, cylinders, capsules, spheres, ovoids, pinwheels, nautilus, and combinations thereof. 17. A method of drug delivery comprising the steps of: forming a housing comprising a polymeric material in situ, the polymeric material comprising a first precursor comprising electrophilic groups and a second precursor comprising nucleophilic groups;introducing at least one bioactive agent and precursors comprising a biodegradable hydrogel into the housing, the precursors comprising a first hydrogel precursor comprising electrophilic groups and a second hydrogel precursor comprising nucleophilic groups; andallowing the precursors to form the biodegradable hydrogel within the housing. 18. The method of claim 17, further comprising the step of hydrating the biodegradable hydrogel prior to filling the housing. 19. The method of claim 17, further comprising dehydrating the biodegradable hydrogel prior to filling the housing. 20. The method of claim 17, further comprising coating the housing with at least one outer layer. 21. The method of claim 17, wherein the housing is coated with from about 1 to about 10 outer layers.
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